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Nutraceutical Regulation of the Neuroimmunoendocrine Super-system

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Pharma-Nutrition

Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 12))

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Abstract

It is clear that nutrition affects a range of biological processes that are critical to the immune response including cell proliferation and survival, signal transduction and gene expression. Consequently, there is an increased interest in the use of dietary strategies to control a range of inflammatory and immune disorders.

The gastrointestinal tract is deeply integrated into many aspects of host physiology, influencing neural and endocrine responses that help maintain immune homeostasis. Thus, in addition to direct effects on the immune system, nutritional interventions can alter components of the neuroendocrine system that in turn play a critical role in regulating systemic immunity. This review focuses on the actions of probiotic bacteria and n3 polyunsaturated fatty acids (n3 PUFAs) on the enteric nervous system, vagus nerve and hypothalamus–pituitary–adrenal (HPA) axis that may contribute to the therapeutic effects of nutraceuticals in immune disorders.

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  1. Department of Medicine, The McMaster Brain-Body Institute, St. Joseph’s Healthcare, McMaster University, 50 Charlton Avenue East, T3302, Hamilton, ON, Canada, L8N 4A6

    Paul Forsythe

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  1. Pharmacology, Utrecht University, The Netherlands

    Gert Folkerts

  2. Immunopharmacology, Utrecht University, The Netherlands

    Johan Garssen

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Forsythe, P. (2014). Nutraceutical Regulation of the Neuroimmunoendocrine Super-system. In: Folkerts, G., Garssen, J. (eds) Pharma-Nutrition. AAPS Advances in the Pharmaceutical Sciences Series, vol 12. Springer, Cham. https://doi.org/10.1007/978-3-319-06151-1_21

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