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Potential Driver Genes Regulated by OncomiRNA Are Associated with Druggability in Pan-Negative Melanoma

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Intelligent Computing in Bioinformatics (ICIC 2014)

Part of the book series: Lecture Notes in Computer Science ((LNBI,volume 8590))

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Abstract

OncomiRNAs (oncomiRs) are small regulatory microRNAs (miRNAs) that play an important role in tumor formation and progression. These oncomiRs are found to regulate different types of tumor by targeting a large set of cancer driver genes (including oncogenes and tumor suppressor genes). In the present work, we have developed a pipeline for the identification of frequently occurring and clinically relevant driver genes in pan-negative melanoma (absence of mutations in BRAF (affecting V600), NRAS (G12, G13, and Q61), KIT (W557, V559, L576, K642, D816), GNAQ (Q209), and GNA11 (Q209) by integrating oncomiRs regulated genes and frequently mutated genes in melanoma pan-negative samples. The preliminary experience has identified 28 potential driver genes that are regulated by oncomiRs, of which 25 genes are associated with drugs, 3 differentially expressed genes are associated with metastasis. This analysis provides a method to mine clinically relevant driver genes in pan-negative melanomas.

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Author information

Authors and Affiliations

  1. Institute of Health Sciences, Anhui University, Hefei, Anhui, 230601, China

    Di Zhang & Junfeng Xia

  2. School of Life Sciences, Anhui University, Hefei, Anhui, 230601, China

    Di Zhang

Authors
  1. Di Zhang
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  2. Junfeng Xia
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Editor information

Editors and Affiliations

  1. School of Electronics and Information Engineering, Tongji University, 4800 Caoan Road, 201804, Shanghai, China

    De-Shuang Huang

  2. School of Computer Science and Engineering Inha University, Incheon, South Korea

    Kyungsook Han

  3. Department of Biotechnology, Indian Institute of Technology Madras, 600 036, Chennai, Tamilnadu, India

    Michael Gromiha

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© 2014 Springer International Publishing Switzerland

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Zhang, D., Xia, J. (2014). Potential Driver Genes Regulated by OncomiRNA Are Associated with Druggability in Pan-Negative Melanoma. In: Huang, DS., Han, K., Gromiha, M. (eds) Intelligent Computing in Bioinformatics. ICIC 2014. Lecture Notes in Computer Science(), vol 8590. Springer, Cham. https://doi.org/10.1007/978-3-319-09330-7_38

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  • DOI: https://doi.org/10.1007/978-3-319-09330-7_38

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-09329-1

  • Online ISBN: 978-3-319-09330-7

  • eBook Packages: Computer ScienceComputer Science (R0)

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