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Preanalytics in Lung Cancer

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Pre-Analytics of Pathological Specimens in Oncology

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 199))

Abstract

Preanalytic sampling techniques and preparation of tissue specimens strongly influence analytical results in lung tissue diagnostics both on the morphological but also on the molecular level. However, in contrast to analytics where tremendous achievements in the last decade have led to a whole new portfolio of test methods, developments in preanalytics have been minimal. This is specifically unfortunate in lung cancer, where usually only small amounts of tissue are at hand and optimization in all processing steps is mandatory in order to increase the diagnostic yield. In the following, we provide a comprehensive overview on some aspects of preanalytics in lung cancer from the method of sampling over tissue processing to its impact on analytical test results. We specifically discuss the role of preanalytics in novel technologies like next-generation sequencing and in the state-of the-art cytology preparations. In addition, we point out specific problems in preanalytics which hamper further developments in the field of lung tissue diagnostics.

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Author information

Authors and Affiliations

  1. Institute of Pathology, Heidelberg University, Heidelberg, Germany

    Arne Warth & Wilko Weichert

  2. Translational Research Unit, Thoraxklinik at Heidelberg University, Heidelberg, Germany

    Thomas Muley & Michael Meister

Authors
  1. Arne Warth
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  2. Thomas Muley
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  3. Michael Meister
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  4. Wilko Weichert
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Corresponding author

Correspondence to Wilko Weichert .

Editor information

Editors and Affiliations

  1. Institute of Pathology, Charité University Medicine, Berlin, Germany

    Manfred Dietel

  2. Institute of Pathology, University Hospital Leipzig, Leipzig, Sachsen, Germany

    Christian Wittekind

  3. University of Turin Institute of Pathology, Turin, Italy

    Gianni Bussolati

  4. Institute of Pathology, Charité University Medicine, Berlin, Germany

    Moritz von Winterfeld

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© 2015 Springer International Publishing Switzerland

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Warth, A., Muley, T., Meister, M., Weichert, W. (2015). Preanalytics in Lung Cancer. In: Dietel, M., Wittekind, C., Bussolati, G., von Winterfeld, M. (eds) Pre-Analytics of Pathological Specimens in Oncology. Recent Results in Cancer Research, vol 199. Springer, Cham. https://doi.org/10.1007/978-3-319-13957-9_8

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  • DOI: https://doi.org/10.1007/978-3-319-13957-9_8

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-13956-2

  • Online ISBN: 978-3-319-13957-9

  • eBook Packages: MedicineMedicine (R0)

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