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History of Crohn’s Disease

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Crohn’s Disease

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Abstract

There is no doubt that the existence of Crohn’s disease has pre-dated our ability to understand and define it. In fact, a precise definition continues to elude us to this day, relying mostly on phenotype to describe the diverse presentations of the disease. This lack of precision, compounded by rudimentary and perfunctory specimen evaluation techniques of the past, left Crohn’s disease an undiscovered entity until the 1932 seminal paper by Crohn and Ginzburg and Oppenheimer (CGO) [1]. We now recognize the incidence rate to be as high as 16 per 100,000 worldwide [2–4]. The history of Crohn’s disease is a tale of discovery that is far from complete and has utilized many of the advances of medical science to improve the precision of both diagnosis and treatment. Surgical therapy has evolved from primary treatment to being reserved for medically refractory or complicated cases. Medical therapy, once predominated by therapeutic nihilism between surgical episodes, has evolved with more sophisticated trials and therapies now including narrowly targeted drugs. Herein, we review the early descriptions of Crohn’s disease prior to its initial description, its origins at The Mount Sinai Hospital and the medical revolution that has occurred subsequent to the landmark 1932 article.

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Acknowledgments

The authors wish to acknowledge the invaluable contributions made by Arthur H. Aufses, Jr., M.D., who was kind enough to critically review the manuscript, and who provided us with access to his personal photographs, and by Barbara J. Niss, Archivist of the Mount Sinai Medical Center, who provided us with access to the Mount Sinai Levy Library Archives.

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Authors and Affiliations

  1. Division of Colon and Rectal Surgery, Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA

    Joseph E. Bornstein MD

  2. Division of Colon and Rectal Surgery, Mount Sinai Medical Center, One Gustave L. Levy Place, Box 1259, New York, NY, 10029, USA

    Randolph M. Steinhagen MD

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  1. Joseph E. Bornstein MD
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Correspondence to Randolph M. Steinhagen MD .

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Editors and Affiliations

  1. Department of Surgery, University of Washington Medical Center, Seattle, Washington, USA

    Alessandro Fichera

  2. Department of Surgery, University of Washington Medical Center, Seattle, Washington, USA

    Mukta K. Krane

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Bornstein, J.E., Steinhagen, R.M. (2015). History of Crohn’s Disease. In: Fichera, A., Krane, M. (eds) Crohn’s Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-14181-7_1

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