Abstract
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a cytotoxic T-cell lymphoma with an excellent prognosis. Patients present with recurrent, generally painless, erythematous subcutaneous tumors on the trunk and extremities, often followed by lipoatrophy. Of note, this diagnosis previously encompassed two different diseases: lymphomas composed of alpha/beta-type T cells and lymphomas of gamma/delta T cells [1]. In the most recent WHO-EORTC guidelines, these have now been separated into SPTCL and primary cutaneous gamma/delta T-cell lymphoma (pcGDTCL), respectively [2]. Older studies, which lumped together both the alpha/beta and gamma/delta lymphomas, may report lower 5-year survival rates and poorer prognosis, reflecting the more aggressive course of pcGDTCL. This chapter discusses the clinical presentation, prognosis, and treatment of SPTCL, as well as its histopathology and immunohistochemistry. The chapter closes with a differential diagnosis and a clinical case.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Salhany K, Macon W. Subcutaneous panniculitis-like T-cell lymphoma: clinicopathologic, immunophenotypic, and genotypic analysis of alpha/beta and gamma/delta subtypes. Am J Surg Pathol. 1998;22:881–93.
Willemze R, Jansen PM, Cerroni L, Berti E, Santucci M, Assaf C, et al. Subcutaneous panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC Cutaneous Lymphoma Group Study of 83 cases. Blood. 2008;111:838–45.
Jaffe ES, Gaulard P, Ralfkiaer E, Cerroni L, Meijer CJLM. Subcutaneous panniculitis-like T-cell lymphoma. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al., editors. WHO classification of tumors of haematopoietic and lymphoid tissues. Lyon: International Agency for Research on Cancer; 2008. p. 294–5.
Kumar S, Krenacs L, Medeiros J, Elenitoba-Johnson KS, Greiner TC, Sorbara L, et al. Subcutaneous panniculitic T-cell lymphoma is a tumor of cytotoxic T lymphocytes. Hum Pathol. 1998;29:397–403.
Gonzalez CL, Medeiros LJ, Braziel RM, Jaffe ES. T-cell lymphoma involving subcutaneous tissue. A clinicopathologic entity commonly associated with hemophagocytic syndrome. Am J Surg Pathol. 1991;15:17–27.
Wang HH, Myers T, Lach LJ, Hsieh CC, Kadin ME. Increased risk of lymphoid and nonlymphoid malignancies in patients with lymphomatoid papulosis. Cancer. 1999;86:1240–5.
Parveen Z, Thompson K. Subcutaneous panniculitis-like T-cell lymphoma: redefinition of diagnostic criteria in the recent World Health Organization-European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas. Arch Pathol Lab Med. 2009;133:303–8.
Magro CM, Crowson A, Kovatich A, Burns F. Lupus profundus, indeterminate lymphocytic lobular panniculitis and subcutaneous T-cell lymphoma: a spectrum of subcuticular T-cell lymphoid dyscrasia. J Cutan Pathol. 2001;28:235–47.
Von den Driesch P, Staib G, Simon M, Sterry W. Subcutaneous T-cell lymphoma. J Am Acad Dermatol. 1997;36:285–9.
Santucci M, Pimpinelli N, Massi D, Kadin ME, Meijer CJLM, Müller-Hermelink HK, et al. Cytotoxic/natural killer cell cutaneous lymphomas. Report of EORTC Cutaneous Lymphoma Task Force Workshop. Cancer. 2003;97:610–27.
Gaulard P, Berti E, Willemze R, Jaffe ES. Primary cutaneous peripheral T-cell lymphomas, rare subtypes. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al., editors. WHO classification of tumors of haematopoietic and lymphoid tissues. Lyon: International Agency for Research on Cancer; 2008. p. 302–5.
Krenacs L, Smyth MJ, Bagdi E, Krenacs T, Kopper L, Rudiger T, et al. The serine protease granzyme M is preferentially expressed in NK-cell, gamma delta T-cell, and intestinal T-cell lymphomas: evidence of origin from lymphocytes involved in innate immunity. Blood. 2003;101:3590–3.
Cribier B, Caille A, Heid E, Grosshans E. Erythema nodosum and associated diseases. A study of 129 cases. Int J Dermatol. 1998;37:667–72.
Thurber S, Kohler S. Histopathologic spectrum of erythema nodosum. J Cutan Pathol. 2006;33:18–26.
Pincus LB, LeBoit PE, McCalmont TH, Ricci R, Buzio C, Fox LP, et al. Subcutaneous panniculitis-like T-cell lymphoma with overlapping clinicopathologic features of lupus erythematosus: coexistence of 2 entities? Am J Dermatopathol. 2009;31:520–6.
Watanabe T, Tsuchida T. Lupus erythematosus profundus: a cutaneous marker for a distinct clinical subset? Br J Dermatol. 1996;134:123–5.
Martens P, Moder K, Ahmed I. Lupus panniculitis: clinical perspectives from a case series. J Rheumatol. 1999;26:68–72.
Facchetti F, Jones D, Petrella T. Blastic plasmacytoid dendritic cell neoplasm. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al., editors. WHO classification of tumors of haematopoietic and lymphoid tissues. Lyon: International Agency for Research on Cancer; 2008. p. 145–7.
Beaty MW, Toro J, Sorbara L, Stern JB, Pittaluga S, Raffeld M, et al. Cutaneous lymphomatoid granulomatosis: correlation of clinical and biologic features. Am J Surg Pathol. 2001;25:1111–20.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Goyal, A., Carter, J.B., Duncan, L.M. (2015). Subcutaneous Panniculitis-Like T-Cell Lymphoma. In: Carter, J., Goyal, A., McDivitt Duncan, L. (eds) Atlas of Cutaneous Lymphomas. Springer, Cham. https://doi.org/10.1007/978-3-319-17217-0_8
Download citation
DOI: https://doi.org/10.1007/978-3-319-17217-0_8
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-17216-3
Online ISBN: 978-3-319-17217-0
eBook Packages: MedicineMedicine (R0)