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General Concepts: Management of Asymptomatic Cerebrovascular Disease

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Ischemic Stroke Therapeutics

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Abstract

In this overview about clinical and biologic concepts of asymptomatic cerebrovascular disease and carotid artery stenosis, we review the evolution of the definition of asymptomatic cerebrovascular disease, the clinical significance of asymptomatic carotid artery stenosis and bruit, major surgical and endovascular trials of asymptomatic carotid artery stenosis, predictive importance of carotid artery plaque morphology, and future directions that the field may take. Asymptomatic carotid artery disease remains a topic of debate and there is a need for additional scientific study.

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Abbreviations

ACAS:

Asymptomatic Carotid Atherosclerosis Study

ACST:

Asymptomatic Carotid Surgery Trial

CEA:

Carotid endarterectomy

CI:

Confidence interval

c-IMT:

Carotid intima-media thickness

CNS:

Central nervous system

CREST:

Carotid Revascularization Endarterectomy versus Stenting Trial

MRC ACST:

Medical Research Council Asymptomatic Carotid Surgery Trial

NASCET:

North American Symptomatic Carotid Endarterectomy Trial

PET:

Positron emission tomography

TCD:

Transcranial Doppler

US:

United States

VA:

Veterans Affairs

Vs.:

Versus

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Authors and Affiliations

  1. Department of Translational Science and Molecular Medicine, Michigan State University College of Human Medicine, Mercy Health Hauenstein Neurosciences, 220 Cherry Street SE Room H3037, Grand Rapids, MI, 49503, USA

    Philip B. Gorelick M.D., M.P.H.

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  1. Philip B. Gorelick M.D., M.P.H.
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Correspondence to Philip B. Gorelick M.D., M.P.H. .

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Editors and Affiliations

  1. Admiral Pihl Professor and Chairman of Neurology, Medical University of South Carolina, Charleston, South Carolina, USA

    Bruce Ovbiagele

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Gorelick, P.B. (2016). General Concepts: Management of Asymptomatic Cerebrovascular Disease. In: Ovbiagele, B. (eds) Ischemic Stroke Therapeutics. Springer, Cham. https://doi.org/10.1007/978-3-319-17750-2_24

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  • DOI: https://doi.org/10.1007/978-3-319-17750-2_24

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