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Physiological Consequences: Early Hardship and Health Across the Life Span

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Traumatic Stress and Long-Term Recovery

Abstract

The overall aim of this chapter is to describe the myriad ways in which early trauma (i.e., adversity, abuse, and poverty) impacts physiology and health across the life span. Reviewed studies focus on the consequences of early adversity for the hypothalamic–pituitary–adrenal axis, immune functioning, cardiovascular health, chronic disease, and disability prevalence. Studies are also examined for their measurement strategy, specifically as to whether adversity is quantified as a frequency count of exposures or as independent exposure types. Despite differences in measurement strategies and outcomes across studies, many of the studies reviewed support the wide-reaching effects for youth and adults of early trauma exposure. In addition, health-relevant behaviors that have been linked directly or indirectly to early adversity and health are discussed, including overweight/obesity, smoking, alcohol and other substance abuse, and risky sexual behaviors. Finally, measurement challenges as well as individual factors relevant to adversity and health are briefly reviewed. Overall, the work reviewed in this chapter provides trauma researchers with an introduction to the physiological consequences of early adversity across the life span, and provides suggestions for future work in this area.

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References

  • Afifi, T. O., Brownridge, D. A., Cox, B. J., & Sareen, J. (2006). Physical punishment, childhood abuse and psychiatric disorders. Child Abuse and Neglect, 30(10), 1093–1103.

    Article  PubMed  Google Scholar 

  • American Psychiatric Association (APA). (2013). Diagnostic and statistical manual of mental disorders (5th ed. Text Revised). Washington, D.C.: American Psychiatric Association

    Google Scholar 

  • Anda, R., Felitti, V., Bremner, J., Walker, J. D., Whitfield, C., Perry, B. D., et al. (2006). The enduring effects of abuse and related adverse experiences in childhood: A convergence of evidence from neurobiology and epidemiology. European Archives of Psychiatry and Clinical Neuroscience, 256(3), 174–186.

    Article  PubMed Central  PubMed  Google Scholar 

  • Archer, J. A., Hutchison, I. L., Dorudi, S., Stansfeld, S. A, & Korszun, A. (2012). Interrelationship of depression, stress and inflammation in cancer patients: A preliminary study. Journal of Affective Disorders, 143(1–3), 39–46.

    Article  PubMed  Google Scholar 

  • Baldassari, A. R., Cleveland, R. J., & Callahan, L. F. (2013). Independent associations of childhood and current socioeconomic status with risk of self-reported doctor-diagnosed arthritis in a family-medicine cohort of North-Carolinians. BMC Musculoskeletal Disorders, 14, 327.

    Article  PubMed Central  PubMed  Google Scholar 

  • Belsky, J., Steinberg, L., Houts, R. M., & Halpern-Felsher, B. L. (2010). The development of reproductive strategy in females: Early maternal harshness → earlier menarche → increased sexual risk taking. Developmental Psychology, 46(1), 120–128.

    Article  PubMed  Google Scholar 

  • Bernstein, D. P., Fink, L., Handelsman, L., Foote, J., Lovejoy, M., Wenzel, K., et al. (1994). Initial reliability and validity of a new retrospective measure of child abuse and neglect. The American Journal of Psychiatry, 151(8), 1132–1136.

    Article  PubMed  Google Scholar 

  • Bernstein, D. P., Stein, J. A., Newcomb, M. D., Walker, E., Pogge, D., Ahluvalia, T., et al. (2003). Development and validation of a brief screening version of the childhood trauma questionnaire. Child Abuse and Neglect, 27(2), 169–190.

    Article  PubMed  Google Scholar 

  • Boynton-Jarrett, R., Fargnoli, J., Suglia, S. F., Zuckerman, B., & Wright, R. J. (2010). Association between maternal intimate partner violence and incident obesity in preschool-aged children: Results from the fragile families and child well-being study. Archives of Pediatrics and Adolescent Medicine, 164(6), 540–546.

    Article  PubMed  Google Scholar 

  • Boynton-Jarrett, R., Rosenberg, L., Palmer, J. R., Boggs, D. A., & Wise, L. A. (2012). Child and adolescent abuse in relation to obesity in adulthood: The Black Women’s Health Study. Pediatrics, 130(2), 245–253.

    Article  PubMed Central  PubMed  Google Scholar 

  • Braveman, P., & Barclay, C. (2009). Health disparities beginning in childhood: A life-course perspective. Pediatrics, 124, S163–S175.

    Article  PubMed  Google Scholar 

  • Bremner, J. D., Bolus, R., & Mayer, E. A. (2007). Psychometric properties of the early trauma inventory—Self report. The Journal of Nervous and Mental Disease, 195(3), 211–218.

    Article  PubMed Central  PubMed  Google Scholar 

  • Brody, G. H., Yu, T., Chen, E., Miller, G. E., Kogan, S. M., & Beach, S. R. H. (2013). Is resilience only skin deep? Rural African Americans’ socioeconomic status-related risk and competence in preadolescence and psychological adjustment and allostatic load at age 19. Psychological Science, 24(7), 1285–1293.

    Article  PubMed Central  PubMed  Google Scholar 

  • Brown, D. W., Anda, R. F., Felitti, V. J., Edwards, V. J., Malarcher, A. M., Croft, J. B., et al. (2010). Adverse childhood experiences are associated with the risk of lung cancer: A prospective cohort study. BMC Public Health, 10, 20.

    Article  PubMed Central  PubMed  Google Scholar 

  • Brummett, B. H., Babyak, M. A, Singh, A., Jiang, R., Williams, R. B., Harris, K. M., et al. (2013). Socioeconomic indices as independent correlates of C-reactive protein in the National Longitudinal Study of Adolescent Health. Psychosomatic Medicine, 75(9), 882–893.

    Article  PubMed Central  PubMed  Google Scholar 

  • Brunner, E., Smith, G. D., Marmot, M., Canner, R., Beksinska, M., & O’Brien, J. (1996). Childhood social circumstances and psychosocial and behavioural factors as determinants of plasma fibrinogen. Lancet, 347(9007), 1008–1013.

    Article  PubMed  Google Scholar 

  • Burgermeister, D. (2007). Childhood adversity: A review of measurement instruments. Journal of Nursing Measurement, 15(3), 163–176.

    Article  PubMed  Google Scholar 

  • Calixto, O.-J., & Anaya, J.-M. (2014). Socioeconomic status. The relationship with health and autoimmune diseases. Autoimmunity Reviews, 13(6), 641–654.

    Article  PubMed  Google Scholar 

  • Carlsson, E., Frostell, A., Ludvigsson, J., & Faresjo, M. (2014). Psychological stress in children may alter the immune response. The Journal of Immunology, 192(5), 2071–2081.

    Article  PubMed  Google Scholar 

  • Carpenter, L. L., Tyrka, A. R., Ross, N. S., Khoury, L., Anderson, G. M., & Price, L. H. (2009). Effect of childhood emotional abuse and age on cortisol responsivity in adulthood. Biological Psychiatry, 66(1), 69–75.

    Article  PubMed Central  PubMed  Google Scholar 

  • Carpenter, L. L., Gawuga, C. E., Tyrka, A. R., Lee, J. K., Anderson, G. M., & Price, L. H. (2010). Association between plasma IL-6 response to acute stress and early-life adversity in healthy adults. Neuropsychopharmacology, 35(13), 2617–2623.

    Article  PubMed Central  PubMed  Google Scholar 

  • Carroll, J. E., Gruenewald, T. L., Taylor, S. E., Janicki-Deverts, D., Matthews, K. A, & Seeman, T. E. (2013). Childhood abuse, parental warmth, and adult multisystem biological risk in the coronary artery risk development in young adults study. Proceedings of the National Academy of Sciences of the United States of America, 110(42), 17149–17153.

    Article  PubMed Central  PubMed  Google Scholar 

  • Champion, J. D., Piper, J. M., Holden, A. E. C., Shain, R. N., Perdue, S., & Korte, J. E. (2005). Relationship of abuse and pelvic inflammatory disease risk behavior in minority adolescents. Journal of the American Academy of Nurse Practitioners, 17(6), 234–241.

    Article  PubMed  Google Scholar 

  • Chen, E., & Paterson, L. Q. (2006). Neighborhood, family, and subjective socioeconomic status: How do they relate to adolescent health? Health Psychology, 25(6), 704–714.

    Article  PubMed  Google Scholar 

  • Chen, E., Cohen, S., & Miller, G. E. (2010). How low socioeconomic status affects 2-year hormonal trajectories in children. Psychological Science, 21(1), 31–37.

    Article  PubMed  Google Scholar 

  • Chen, E., Lee, W. K., Cavey, L., & Ho, A. (2013). Role models and the psychological characteristics that buffer low-socioeconomic-status youth from cardiovascular risk. Child Development, 84(4), 1241–1252.

    Article  PubMed  Google Scholar 

  • Coelho, R., Viola, T. W., Walss-Bass, C., Brietzke, E., & Grassi-Oliveira, R. (2014). Childhood maltreatment and inflammatory markers: A systematic review. Acta Psychiatrica Scandinavica, 129(3), 180–192.

    Article  PubMed  Google Scholar 

  • Cohen, S., Janicki-Deverts, D., Chen, E., & Matthews, K. A. (2010). Childhood socioeconomic status and adult health. Annals of the New York Academy of Sciences, 1186, 37–55.

    Article  PubMed  Google Scholar 

  • Cuijpers, P., Smit, F., Unger, F., Stikkelbroek, Y., Ten Have, M., & de Graaf, R. (2011). The disease burden of childhood adversities in adults: A population-based study. Child Abuse and Neglect, 35(11), 937–945.

    Article  PubMed  Google Scholar 

  • Danese, A., Pariante, C. M., Caspi, A., Taylor, A., & Poulton, R. (2007). Childhood maltreatment predicts adult inflammation in a life-course study. Proceedings of the National Academy of Sciences of the United States of America, 104(4), 1319–1324.

    Article  PubMed Central  PubMed  Google Scholar 

  • Danese, A., Caspi, A., Williams, B., Ambler, A., Sugden, K., Mika, J., et al. (2011). Biological embedding of stress through inflammation processes in childhood. Molecular Psychiatry, 16(3), 244–246.

    Article  PubMed Central  PubMed  Google Scholar 

  • Danielson, C. K., Amstadter, A., Dangelmaier, R. E., Resnick, H. S., Saunders, B. E., & Kilpatrick, D. G. (2009). Does typography of substance abuse and dependence differ as a function of exposure to child maltreatment? Journal of Child and Adolescent Substance Abuse, 18(4), 323.

    Article  PubMed Central  PubMed  Google Scholar 

  • Davis, C. R., Dearing, E., Usher, N., Trifiletti, S., Zaichenko, L., Ollen, E., et al. (2014). Detailed assessments of childhood adversity enhance prediction of central obesity independent of gender, race, adult psychosocial risk and health behaviors. Metabolism: Clinical and Experimental, 63(2), 199–206.

    Article  Google Scholar 

  • Doan, S. N., Dich, N., & Evans, G. W. (in press). Childhood cumulative risk and later allostatic load: Mediating role of substance use. Health Psychology. Advance online publication.

    Google Scholar 

  • Dong, M., Giles, W. H., Felitti, V. J., Dube, S. R., Williams, J. E., Chapman, D. P., et al. (2004). Insights into causal pathways for ischemic heart disease: Adverse childhood experiences study. Circulation, 110(13), 1761–1766.

    Article  PubMed  Google Scholar 

  • Douglas, K., Chan, G., Gelernter, J., Arias, A. J., Anton, R. F., Weiss, R. D., et al. (2010). Adverse childhood events as risk factors for substance dependence: Partial mediation by mood and anxiety disorders. Addictive Behaviors, 35(1), 7–13.

    Article  PubMed Central  PubMed  Google Scholar 

  • Dowd, J. B., Simanek, A. M., & Aiello, A. E. (2009). Socio-economic status, cortisol and allostatic load: A review of the literature. International Journal of Epidemiology, 38(5), 1297–1309.

    Article  PubMed Central  PubMed  Google Scholar 

  • Dowd, J. B., Palermo, T. M., & Aiello, A. E. (2012). Family poverty is associated with cytomegalovirus antibody titers in U.S. Children. Health Psychology, 31(1), 5–10.

    Article  PubMed Central  PubMed  Google Scholar 

  • Dube, S. R., Williamson, D. F., Thompson, T., Felitti, V. J., & Anda, R. F. (2004). Assessing the reliability of retrospective reports of adverse childhood experiences among adult HMO members attending a primary care clinic. Child Abuse and Neglect, 28(7), 729–737.

    Article  PubMed  Google Scholar 

  • Elliott, J. C., Stohl, M., Wall, M. M., Keyes, K. M., Goodwin, R. D., Skodol, A. E., et al. (2014). The risk for persistent adult alcohol and nicotine dependence: The role of childhood maltreatment. Addiction, 109(5), 842–850.

    Article  PubMed Central  PubMed  Google Scholar 

  • Ershler, W. B., & Keller, E. T. (2000). Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annual Review of Medicine, 51, 245–270.

    Article  PubMed  Google Scholar 

  • Evans, G. W., & Kim, P. (2010). Multiple risk exposure as a potential explanatory mechanism for the socioeconomic status-health gradient. Annals of the New York Academy of Sciences, 1186, 174–189.

    Article  PubMed  Google Scholar 

  • Felitti, V. J., Anda, R. F., Nordeberg, D., Williamson, D. F., Spitz, A. M., Edwards, V., et al. (1998). Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults: The Adverse Childhood Experiences (ACE) study. American Journal of Preventive Medicine, 14(4), 245–258.

    Article  PubMed  Google Scholar 

  • Ford, J. L., & Browning, C. R. (2014). Effects of exposure to violence with a weapon during adolescence on adult hypertension. Annals of Epidemiology, 24(3), 193–198.

    Article  PubMed Central  PubMed  Google Scholar 

  • Ford, E. S., Anda, R. F., Edwards, V. J., Perry, G. S., Zhao, G., Li, C., et al. (2011). Adverse childhood experiences and smoking status in five states. Preventive Medicine, 53(3), 188–193.

    Article  PubMed  Google Scholar 

  • Fuller-Thomson, E., Brennenstuhl, S., & Frank, J. (2010). The association between childhood physical abuse and heart disease in adulthood: Findings from a representative community sample. Child Abuse and Neglect, 34(9), 689–698.

    Article  PubMed  Google Scholar 

  • Fuller-Thomson, E., Bejan, R., Hunter, J. T., Grundland, T., & Brennenstuhl, S. (2012). The link between childhood sexual abuse and myocardial infarction in a population-based study. Child Abuse and Neglect, 36(9), 656–665.

    Article  PubMed  Google Scholar 

  • Galobardes, B., Smith, G. D., & Lynch, J. W. (2006). Systematic review of the influence of childhood socioeconomic circumstances on risk for cardiovascular disease in adulthood. Annals of Epidemiology, 16(2), 91–104.

    Article  PubMed  Google Scholar 

  • Giesinger, I., Goldblatt, P., Howden-Chapman, P., Marmot, M., Kuh, D., & Brunner, E. (2014). Association of socioeconomic position with smoking and mortality: The contribution of early life circumstances in the 1946 birth cohort. Journal of Epidemiology and Community Health, 68(3), 275–279.

    Article  PubMed Central  PubMed  Google Scholar 

  • Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Blaha, M. J., et al. (2014). Heart disease and stroke statistics—2014 update: A report from the American Heart Association. Circulation, 129, e28–e292.

    Article  PubMed  Google Scholar 

  • Goldman-Mellor, S., Hamer, M., & Steptoe, A. (2012). Early-life stress and recurrent psychological distress over the lifecourse predict divergent cortisol reactivity patterns in adulthood. Psychoneuroendocrinology, 37(11), 1755–1768.

    Article  PubMed  Google Scholar 

  • Goodwin, L., White, P. D., Hotopf, M., Stansfeld, S. A., & Clark, C. (2013). Life course study of the etiology of self-reported irritable bowel syndrome in the 1958 British birth cohort. Psychosomatic Medicine, 75(2), 202–210.

    Article  PubMed  Google Scholar 

  • Gouin, J.-P., Glaser, R., Malarkey, W. B., Beversdorf, D., & Kiecolt-Glaser, J. K. (2012). Childhood abuse and inflammatory responses to daily stressors. Annals of Behavioral Medicine, 44(2), 287–292.

    Article  PubMed Central  PubMed  Google Scholar 

  • Greenfield, E. A., & Marks, N. F. (2009). Profiles of physical and psychological violence in childhood as a risk factor for poorer adult health: Evidence from the 1995–2005 National Survey of Midlife in the United States. Journal of Aging and Health, 21(7), 943–966.

    Article  PubMed Central  PubMed  Google Scholar 

  • Hahm, H. C., Lee, Y., Ozonoff, A., & Van Wert, M. J. (2010). The impact of multiple types of child maltreatment on subsequent risk behaviors among women during the transition from adolescence to young adulthood. Journal of Youth and Adolescence, 39(5), 528–540.

    Article  PubMed Central  PubMed  Google Scholar 

  • Hanson, M. D., & Chen, E. (2010). Daily stress, cortisol, and sleep: The moderating role of childhood psychosocial environments. Health Psychology, 29(4), 394–402.

    Article  PubMed  Google Scholar 

  • Heim, C., Newport, D. J., Bonsall, R., Miller, A. H., & Nemeroff, C. B. (2001). Altered pituitary-adrenal axis responses to provocative challenge tests in adult survivors of childhood abuse. The American Journal of Psychiatry, 158(4), 575–581.

    Article  PubMed  Google Scholar 

  • Heim, C., Wagner, D., Maloney, E., Papanicolaou, D. A., Solomon, L., Jones, J. F., et al. (2006). Early adverse experience and risk for chronic fatigue syndrome: Results from a population-based study. Archives of General Psychiatry, 63, 1258–1266.

    Article  PubMed  Google Scholar 

  • Hillis, S. D., Anda, R. F., Dube, S. R., Felitti, V. J., Marchbanks, P. A., & Marks, J. S. (2004). The association between adverse childhood experiences and adolescent pregnancy, long-term psychosocial consequences, and fetal death. Pediatrics, 113(2), 320–327.

    Article  PubMed  Google Scholar 

  • Hunter, A., Minnis, H., & Wilson, P. (2011). Altered stress responses in children exposed to early adversity: A systematic review of salivary cortisol studies. Stress: The International Journal on the Biology of Stress, 14(6), 614–626.

    Google Scholar 

  • Kalmakis, K. A., & Chandler, G. E. (2014). Adverse childhood experiences: Towards a clear conceptual meaning. Journal of Advanced Nursing, 70(7), 1489–1501.

    Article  PubMed  Google Scholar 

  • Kauhanen, L., Leino, J., Lakka, H.-M., Lynch, J. W., & Kauhanen, J. (2011). Adverse childhood experiences and risk of binge drinking and drunkenness in middle-aged Finnish men. Advances in Preventive Medicine, 2011, 478741.

    Article  PubMed Central  PubMed  Google Scholar 

  • Kennedy, B., ValdimarsdĂłttir, U., Sundström, K., SparĂ©n, P., Lambe, M., Fall, K., et al. (2014). Loss of a parent and the risk of cancer in early life: A nationwide cohort study. Cancer Causes and Control : CCC, 25(4), 499–506.

    Article  PubMed  Google Scholar 

  • Kent, A., & Waller, G. (1998). The impact of childhood emotional abuse: An extension of the child abuse and trauma scale. Child Abuse and Neglect, 22(5), 393–399.

    Article  PubMed  Google Scholar 

  • Kiecolt-Glaser, J. K., Gouin, J.-P., Weng, N.-P., Malarkey, W. B., Beversdorf, D. Q., & Glaser, R. (2011). Childhood adversity heightens the impact of later-life caregiving stress on telomere length and inflammation. Psychosomatic Medicine, 73(1), 16–22.

    Article  PubMed Central  PubMed  Google Scholar 

  • Kittleson, M. M., Meoni, L. A., Wang, N.-Y., Chu, A. Y., Ford, D. E., & Klag, M. J. (2006). Association of childhood socioeconomic status with subsequent coronary heart disease in physicians. Archives of Internal Medicine, 166(21), 2356–2361.

    Article  PubMed  Google Scholar 

  • Kyrou, I., Chrousos, G. P., & Tsigos, C. (2006). Stress, visceral obesity, and metabolic complications. Annals of the New York Academy of Sciences, 1083, 77–110.

    Article  PubMed  Google Scholar 

  • Lee, C., Tsenkova, V., & Carr, D. (2014). Childhood trauma and metabolic syndrome in men and women. Social Science and Medicine, 105, 122–130.

    Article  PubMed Central  PubMed  Google Scholar 

  • Lehman, B. J., Taylor, S. E., Kiefe, C. I., & Seeman, T. E. (2009). Relationship of early life stress and psychological functioning to blood pressure in the CARDIA study. Health Psychology, 28(3), 338–346.

    Article  PubMed Central  PubMed  Google Scholar 

  • Li, L., Power, C., Kelly, S., Kirschbaum, C., & Hertzman, C. (2007). Life-time socio-economic position and cortisol patterns in mid-life. Psychoneuroendocrinology, 32(7), 824–833.

    Article  PubMed  Google Scholar 

  • Loucks, E. B., Taylor, S. E., Polak, J. F., Wilhelm, A., Kalra, P., & Matthews, K. A. (2014). Childhood family psychosocial environment and carotid intima media thickness: The CARDIA study. Social Science and Medicine, 104, 15–22.

    Article  PubMed Central  PubMed  Google Scholar 

  • Luecken, L. J., & Appelhans, B. M. (2006). Early parental loss and salivary cortisol in young adulthood: The moderating role of family environment. Development and Psychopathology, 18(1), 295–308.

    Article  PubMed  Google Scholar 

  • Lumeng, J. C., Wendorf, K., Pesch, M. H., Appugliese, D. P., Kaciroti, N., Corwyn, R. F., & Bradley, R. H. (2013). Overweight adolescents and life events in childhood. Pediatrics, 132(6), e1506–e1512.

    Article  PubMed  Google Scholar 

  • Lupien, S. J., King, S., Meaney, M. J., & McEwen, B. S. (2001). Can poverty get under your skin? Basal cortisol levels and cognitive function in children from low and high socioeconomic status. Development and Psychopathology, 13(3), 653–676.

    Article  Google Scholar 

  • Matthews, K. A., Chang, Y.-F., Thurston, R. C., & Bromberger, J. T. (2014). Child abuse is related to inflammation in mid-life women: Role of obesity. Brain, Behavior, and Immunity, 36, 29–34.

    Article  PubMed Central  PubMed  Google Scholar 

  • McIntyre, R. S., Soczynska, J. K., Liauw, S. S., Woldeyohannes, H. O., Brietzke, E., Nathanson, J., et al. (2012). The association between childhood adversity and components of metabolic syndrome in adults with mood disorders: Results from the international mood disorders collaborative project. International Journal of Psychiatry in Medicine, 43(2), 165–177.

    Article  PubMed  Google Scholar 

  • Midei, A. J., & Matthews, K. A. (2011). Interpersonal violence in childhood as a risk factor for obesity: A systematic review of the literature and proposed pathways. Obesity Reviews, 12(5), e159–e172.

    Article  PubMed Central  PubMed  Google Scholar 

  • Midei, A. J., Matthews, K. A., Chang, Y.-F., & Bromberger, J. T. (2013). Childhood physical abuse is associated with incident metabolic syndrome in mid-life women. Health Psychology, 32(2), 121–127.

    Article  PubMed Central  PubMed  Google Scholar 

  • Miller, G. E., Chen, E., & Zhou, E. S. (2007). If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans. Psychological Bulletin, 133(1), 25–45.

    Article  PubMed  Google Scholar 

  • Miller, G. E., Chen, E., & Parker, K. J. (2011). Psychological stress in childhood and susceptibility to the chronic diseases of aging: Moving towards a model of behavioral and biological mechanisms. Psychological Bulletin, 137(6), 959–997.

    Article  PubMed Central  PubMed  Google Scholar 

  • Moncrief, T., Beck, A. F., Simmons, J. M., Huang, B., & Kahn, R. S. (2014). Single parent households and increased child asthma morbidity. The Journal of Asthma, 51(3), 260–266.

    Article  PubMed Central  PubMed  Google Scholar 

  • Montez, J. K., & Hayward, M. D. (2014). Cumulative childhood adversity, educational attainment, and active life expectancy among U.S. Adults. Demography, 51(2), 413–435.

    Article  PubMed Central  PubMed  Google Scholar 

  • Morton, P. M., Mustillo, S. A., & Ferraro, K. F. (2014). Does childhood misfortune raise the risk of acute myocardial infarction in adulthood? Social Science and Medicine, 104, 133–141.

    Article  PubMed Central  PubMed  Google Scholar 

  • Odgers, C. L., & Jaffee, S. R. (2013). Routine versus catastrophic influences on the developing child. Annual Review of Public Health, 34, 29–48.

    Article  PubMed Central  PubMed  Google Scholar 

  • O’Rand, A. M., & Hamil-Luker, J. (2005). Processes of cumulative adversity: Childhood disadvantage and increased risk of heart attack across the life course. Journals of Gerontology: Series B, 60B(SI–II), 117–124.

    Article  Google Scholar 

  • Pearson, T. A., Mensah, G. A., Alexander, R. W., Anderson, J. L., Cannon III, R. O., Criqui, M., et al. (2003). Markers of inflammation and cardiovascular disease: Application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation, 107(3), 499–511.

    Article  PubMed  Google Scholar 

  • Pollitt, R. A., Rose, K. M., & Kaufman, J. S. (2005). Evaluating the evidence for models of life course socioeconomic factors and cardiovascular outcomes: A systematic review. BMC Public Health, 5, 7.

    Article  PubMed Central  PubMed  Google Scholar 

  • Pollitt, R. A., Kaufman, J. S., Rose, K. M., Diez-Roux, A. V., Zeng, D., & Heiss, G. (2007). Early-life and adult socioeconomic status and inflammatory risk markers in adulthood. European Journal of Epidemiology, 22(1), 55–66.

    Article  PubMed  Google Scholar 

  • Potthast, N., Neuner, F., & Catani, C. (2014). The contribution of emotional maltreatment to alcohol dependence in a treatment-seeking sample. Addictive Behaviors, 39(5), 949–958.

    Article  PubMed  Google Scholar 

  • Poulton, R., Caspi, A., Milne, B. J., Thomson, W. M., Taylor, A., Sears, M. R., & Moffitt, T. E. (2002). Association between children’s experience of socioeconomic disadvantage and adult health: A life-course study. Lancet, 360(9346), 1640–1645.

    Article  PubMed Central  PubMed  Google Scholar 

  • Power, C., Thomas, C., Li, L., & Hertzman, C. (2012). Childhood psychosocial adversity and adult cortisol patterns. The British Journal of Psychiatry, 201(3), 199–206.

    Article  PubMed  Google Scholar 

  • Pretty, C., O’Leary, D. D., Cairney, J., & Wade, T. J. (2013). Adverse childhood experiences and the cardiovascular health of children: A cross-sectional study. BMC Pediatrics, 13, 208.

    Article  PubMed Central  PubMed  Google Scholar 

  • Raposa, E. B., Bower, J. E., Hammen, C. L., Najman, J. M., & Brennan, P. A. (2014). A developmental pathway from early life stress to inflammation: The role of negative health behaviors. Psychological Science, 25(6), 1268–1274.

    Article  PubMed Central  PubMed  Google Scholar 

  • Sanders, B., & Becker-Lausen, E. (1995). The measurement of psychological maltreatment: Early data on the Child Abuse and Trauma scale. Child Abuse and Neglect, 19(3), 315–323.

    Article  PubMed  Google Scholar 

  • Schofield, T. J., Lee, R. D., & Merrick, M. T. (2013). Safe, stable, nurturing relationships as a moderator of intergenerational continuity of child maltreatment: A meta-analysis. The Journal of Adolescent Health, 53(4 Suppl), S32–S38.

    Article  PubMed Central  PubMed  Google Scholar 

  • SchĂĽssler-Fiorenza Rose, S. M., Xie, D., & Stineman, M. (in press). Adverse childhood experiences & disability in U.S. adults. PM & R. Advance online publication.

    Google Scholar 

  • Scott, K. M., Von Korff, M., Angermeyer, M. C., Benjet, C., Bruffaerts, R., de Girolamo, G., et al. (2011). Association of childhood adversities and early-onset mental disorders with adult-onset chronic physical conditions. Archives of General Psychiatry, 68(8), 838–844.

    Article  PubMed Central  PubMed  Google Scholar 

  • Segerstrom, S. C., & Miller, G. E. (2004). Psychological stress and the human immune system: A meta-analytic study of 30 years of inquiry. Psychological Bulletin, 130(4), 601–630.

    Article  PubMed Central  PubMed  Google Scholar 

  • Shonkoff, J. P., Boyce, W. T., & McEwen, B. S. (2009). Neuroscience, molecular biology, and the childhood roots of health disparities: Building a new framework for health promotion and disease prevention. JAMA, 301(21), 2252–2259.

    Article  PubMed  Google Scholar 

  • Slopen, N., Lewis, T. T., Gruenewald, T. L., Mujahid, M. S., Ryff, C. D., Albert, M. A., et al. (2010). Early life adversity and inflammation in African Americans and Whites in the midlife in the United States survey. Psychosomatic Medicine, 72(7), 694–701.

    Article  PubMed Central  PubMed  Google Scholar 

  • Slopen, N., McLaughlin, K. A., Dunn, E. C., & Koenen, K. C. (2013). Childhood adversity and cell-mediated immunity in young adulthood: Does type and timing matter? Brain, Behavior, and Immunity, 28, 63–71.

    Article  PubMed Central  PubMed  Google Scholar 

  • Spann, S. J., Gillespie, C. F., Davis, J. S., Brown, A., Schwartz, A., Wingo, A., et al. (2013). The association between childhood trauma and lipid levels in an adult low-income, minority population. General Hospital Psychiatry, 36(2), 150–155.

    Article  PubMed Central  PubMed  Google Scholar 

  • Springer, K. W. (2009). Childhood physical abuse and midlife physical health: Testing a multi-pathway life course model. Social Science and Medicine, 69(1), 138–146.

    Article  PubMed Central  PubMed  Google Scholar 

  • Stein, D. J., Scott, K., Abad, J. M. H., Aguilar-Gaxiola, S., Alonso, J., Angermeyer, M., et al. (2010). Early childhood adversity and later hypertension: Data from the World Mental Health Survey. Annals of Clinical Psychiatry, 22(1), 19–28.

    PubMed Central  PubMed  Google Scholar 

  • Strand, V. C., Sarmiento, T. L., & Pasquale, L. E. (2005). Assessment and screening tools for trauma in children and adolescents: A review. Trauma, Violence and Abuse, 6(1), 55–78.

    Article  PubMed  Google Scholar 

  • Taylor, S. E., Lerner, J. S., Sage, R. M., Lehman, B. J., & Seeman, T. E. (2004). Early environment, emotions, responses to stress, and health. Journal of Personality, 72(6), 1365–1393.

    Article  PubMed  Google Scholar 

  • Taylor, S. E., Lehman, B. J., Kiefe, C. I., & Seeman, T. E. (2006). Relationship of early life stress and psychological functioning to adult C-reactive protein in the coronary artery risk development in young adults study. Biological Psychiatry, 60(8), 819–824.

    Article  PubMed  Google Scholar 

  • Thabrew, H., de Sylva, S., & Romans, S. E. (2012). Evaluating childhood adversity. Advances in Psychosomatic Medicine, 32, 35–57.

    Article  PubMed  Google Scholar 

  • Tiet, Q. Q., Bird, H. R., Davies, M., Hoven, C., Cohen, P., Jensen, P. S., & Goodman, S. (1998). Adverse life events and resilience. Journal of the American Academy of Child and Adolescent Psychiatry, 37(11), 1191–1200.

    Article  PubMed  Google Scholar 

  • Trickett, P. K., Noll, J. G., Susman, E. J., Shenk, C. E., & Putnam, F. W. (2010). Attenuation of cortisol across development for victims of sexual abuse. Development and Psychopathology, 22(1), 165–175.

    Article  PubMed Central  PubMed  Google Scholar 

  • Trickett, P. K., Gordis, E., Peckins, M. K., & Susman, E. J. (in press). Stress reactivity in maltreated and comparison male and female young adolescents. Child Maltreatment. Advance online publication.

    Google Scholar 

  • van de Mheen, H., Stronks, K., Looman, C. W. N., & Mackenbach, J. P. (1998). Does childhood socioeconomic status influence adult health through behavioural factors? International Journal of Epidemiology, 27(3), 431–437.

    Article  PubMed  Google Scholar 

  • Vilija, M., & Romualdas, M. (2014). Unhealthy food in relation to posttraumatic stress symptoms among adolescents. Appetite, 74, 86–91.

    Article  PubMed  Google Scholar 

  • Walsh, K., Latzman, N. E., & Latzman, R. D. (2014). Pathway from child sexual and physical abuse to risky sex among emerging adults: The role of trauma-related intrusions and alcohol problems. The Journal of Adolescent Health, 54(4), 442–448.

    Article  PubMed Central  PubMed  Google Scholar 

  • Wegman, H. L., & Stetler, C. (2009). A meta-analytic review of the effects of childhood abuse on medical outcomes in adulthood. Psychosomatic Medicine, 71(8), 805–812.

    Article  PubMed  Google Scholar 

  • White, H. R., & Widom, C. S. (2003). Does childhood victimization increase the risk of early death? A 25-year prospective study. Child Abuse and Neglect, 27(7), 841–853.

    Article  PubMed  Google Scholar 

  • Wilson, P. W. F., D’Agostino, R. B., Levy, D., Belanger, A. M., Silbershatz, H., & Kannel, W. B. (1998). Prediction of coronary heart disease using risk factor categories. Circulation, 97(18), 1837–1847.

    Article  PubMed  Google Scholar 

  • Wingo, A. P., Ressler, K. J., & Bradley, B. (2014). Resilience characteristics mitigate tendency for harmful alcohol and illicit drug use in adults with a history of childhood abuse: A cross-sectional study of 2024 inner-city men and women. Journal of Psychiatric Research, 51, 93–99.

    Article  PubMed  Google Scholar 

  • Wise, L. A., Palmer, J. R., & Rosenberg, L. (2013). Lifetime abuse victimization and risk of uterine leiomyomata in Black women. American Journal of Obstetrics and Gynecology, 208(4), 272.e1–272.e13.

    Article  PubMed  Google Scholar 

  • Witek Janusek, L., Tell, D., Albuquerque, K., & Mathews, H. L. (2013). Childhood adversity increases vulnerability for behavioral symptoms and immune dysregulation in women with breast cancer. Brain, Behavior, and Immunity, 30 Suppl, S149–S162.

    Article  Google Scholar 

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Acknowledgments

Support for this research was provided by a grant from the National Institute on Aging (AG026307-R01 and AG028383-P30).

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Correspondence to Jennifer N. Morey PhD .

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Morey, J., Segerstrom, S. (2015). Physiological Consequences: Early Hardship and Health Across the Life Span. In: Cherry, K. (eds) Traumatic Stress and Long-Term Recovery. Springer, Cham. https://doi.org/10.1007/978-3-319-18866-9_9

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