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Therapeutic Uses of Atmospheric Pressure Plasma: Cancer and Wound

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Biomedical Engineering: Frontier Research and Converging Technologies

Part of the book series: Biosystems & Biorobotics ((BIOSYSROB,volume 9))

Abstract

Atmospheric pressure plasma (APP), composed of multiple active components, including charged particles, reactive oxygen species, and radicals, recently emerged as a promising tool in cancer therapy and wound treatment. Driven by the increasingly growing interests on plasma medicine, numerous in vivo tests and in vitro studies on the applicability of the APP for clinical treatments have been performed. In particular, the APP was shown to be effective in removing the targeted cells by causing apoptosis or necrosis. More importantly, in some studies, these effects were demonstrated to be specific to cancer cells, which was further confirmed in animal models where the APP effectively suppressed the tumor growth. In addition to the cancer therapy, the APP treatment targeting the chronic wound has shown that the plasma could improve the healing process by accelerating blood coagulation, bacteria sterilization, and re-epithelialization around the wounded area. Interestingly, the plasma therapy on cutaneous wound also presented promising outcomes in an animal study with reduced scar formations. In this chapter, we report a general overview of the recent trends and progresses in the effects of the APP treatment on cancer and wound, and discuss the potential applications of the APP as a therapeutic tool.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Hanyang University, Wangsimni-ro 222, Seongdong-gu, Seoul, 133-791, Republic of Korea

    Bomi Gweon

  2. Department of Physics, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon, 305-701, Republic of Korea

    Kijung Kim & Wonho Choe

  3. Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon, 305-701, Republic of Korea

    Jennifer H. Shin

  4. Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon, 305-701, Republic of Korea

    Jennifer H. Shin

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  1. Bomi Gweon
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  2. Kijung Kim
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  3. Wonho Choe
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  4. Jennifer H. Shin
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Corresponding author

Correspondence to Jennifer H. Shin .

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Editors and Affiliations

  1. Coulter Department of Biomedical Engineering, Georgia Tech and Emory University, Atlanta, Georgia, USA

    Hanjoong Jo

  2. Department of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, AL, Alabama, USA

    Ho-Wook Jun

  3. Department of Mechanical Engineering Soft Biomechanics & Biomaterials Lab, Korea Advanced Institute of Science and Technology, Daejeon (KAIST), Korea (Republic of)

    Jennifer Shin

  4. Department of Biomedical Engineering, College of Health Science, Korea University, Seoul, Korea (Republic of)

    SangHoon Lee

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Gweon, B., Kim, K., Choe, W., Shin, J.H. (2016). Therapeutic Uses of Atmospheric Pressure Plasma: Cancer and Wound. In: Jo, H., Jun, HW., Shin, J., Lee, S. (eds) Biomedical Engineering: Frontier Research and Converging Technologies. Biosystems & Biorobotics, vol 9. Springer, Cham. https://doi.org/10.1007/978-3-319-21813-7_15

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