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Why and How Epstein-Barr Virus Was Discovered 50 Years Ago

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Epstein Barr Virus Volume 1

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 390))

Abstract

An account is given of the experiences and events which led to a search being undertaken for a causative virus in the recently described Burkitt’s lymphoma and of the steps which ultimately culminated in the discovery of the new human herpesvirus which came to be known as Epstein-Barr virus (EBV).

Based on a lecture presented at EBV@50, the International Meeting in Oxford held in the week of 28 March 2014 to celebrate the 50th Anniversary of the first publication on the virus by Epstein, Achong and Barr on 28 March 1964.

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References

  • Baer R, Bankier AT, Biggin MD et al (1984) DNA sequence and expression of the B95-8 Epstein-Barr virus genome. Nature 310:207–211

    Article  CAS  PubMed  Google Scholar 

  • Belloc H (1897) The microbe in more beasts for worse children. Duckworth & Co., London

    Google Scholar 

  • Bonar RA, Weinstein D, Sommer JR et al (1960) Virus of avian myeloblastosis. XVII. Morphology of progressive virus-myeloblast interactions in vitro. Natl Cancer Inst Monogr 4:251–290

    CAS  PubMed  Google Scholar 

  • Burkitt DP (1963) A lymphoma syndrome in tropical Africa. In: Richter GW, Epstein MA (eds) International review of experimental pathology, vol 2. Academic Press, New York, pp 69–138

    Google Scholar 

  • Burkitt DP (1969) Etiology of Burkitt’s lymphoma—an alternative hypothesis to a vectored virus. J Natl Cancer Inst 42:19–28

    Google Scholar 

  • Epstein MA (1958) Composition of the Rous virus nucleoid. Nature 181:1808

    Article  CAS  PubMed  Google Scholar 

  • Epstein MA, Achong BG (1967) Immunologic relationships of the herpes-like EB virus of cultured Burkitt lymphoblasts. Cancer Res 27:2489–2493

    CAS  PubMed  Google Scholar 

  • Epstein MA, Achong BG, Barr YM (1964) Virus particles in cultured lymphoblasts from Burkitt’s lymphoma. Lancet 1:702–703

    Article  CAS  PubMed  Google Scholar 

  • Epstein MA, Henle G, Achong BG, Barr YM (1965) Morphological and biological studies on a virus in cultured lymphoblasts from Burkitt’s lymphoma. J Exp Med 121:761–770

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Epstein MA, Holt SJ (1958) Observations on the Rous virus; integrated electron microscopical and cytochemical studies of fluorocarbon purified preparations. Br J Cancer 12:363–369

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Fischer GA (1957) Tissue culture of mouse leukemic cells. Proc Am Assn Cancer Res 2:201

    Google Scholar 

  • Fischer GA (1958) Studies of the culture of leukemic cells in vitro. Ann NY Acad Sci 76:673–680

    Google Scholar 

  • Henle G, Henle W (1966) Studies on cell lines derived from Burkitt’s lymphoma. Trans NY Acad Sci 29:71–79

    Google Scholar 

  • Henle G, Henle W, Diehl V (1968) Relation of Burkitt’s tumor-associated herpes-type virus to infectious mononucleosis. Proc Natl Acad Sci USA 59:94–101

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Rous P (1911) A sarcoma of the fowl transmissible by an agent separable from the tumor cells. J Exp Med 13:397–411

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Woodliffe HJ (1964) Blood and bone marrow cell culture. Eyre and Spottiswoode, London

    Google Scholar 

  • zur Hausen H, Schulte-Holthausen H, Klein G et al (1970) EBV DNA in biopsies of Burkitt tumours and anaplastic carcinomas of the nasopharynx. Nature 228:1056–1058

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Anthony Epstein .

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Epstein, A. (2015). Why and How Epstein-Barr Virus Was Discovered 50 Years Ago. In: Münz, C. (eds) Epstein Barr Virus Volume 1. Current Topics in Microbiology and Immunology, vol 390. Springer, Cham. https://doi.org/10.1007/978-3-319-22822-8_1

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