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Pain in the Elderly

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Advances in Geroscience

Abstract

Pain in older adults is a very complex medical challenge as it often emerges with other medical conditions, which not only confounds its clinical assessment but also complicates the choices of effective treatment strategies. In this chapter, the most common types of pain-related clinical conditions in older adults will be presented. This will be followed by discussion of a number of key advances in the field of pain and aging, including in the areas of inflammation, stress, genetics and epigenetics, neuroscience, and psychosocial factors, and how advances in these key areas may help us to better assess pain in older adults as well as to devise personalized effective treatment strategies. Then, we will discuss the current choices of pain therapies, including both pharmacological and non-pharmacological treatments, along with the molecular and cellular mechanisms underlying these therapeutic approaches. At the end, we will outline a number of key future challenges and directions for pain in aging research.

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Acknowledgments

The preparation of this chapter was supported in part by NIH grants K07AG04637 and R37AG033906 (RBF). Preclinical studies related to the effects of age on thermal sensitivity were supported by RAG031821 (RPY).

Editors: Wen G. Chen, National Center for Complementary and Integrative Health (NCCIH/NIH); Joseph Frascella, National Institute on Drug Abuse (NIDA/NIH) and Partap Khalsa (National Center for Complementary and Integrative Health (NCCIH/NIH).

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Authors and Affiliations

  1. Pain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL, USA

    Roger B. Fillingim Ph.D. & Robert P. Yezierski Ph.D.

  2. Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA, USA

    Dennis C. Turk Ph.D.

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  1. Roger B. Fillingim Ph.D.
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  3. Robert P. Yezierski Ph.D.
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Correspondence to Roger B. Fillingim Ph.D. .

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  1. National Inst. of Aging Division of Aging Biology, National Institutes of Health, Bethesda, Maryland, USA

    Felipe Sierra

  2. National Inst on Aging/ National Inst of Health, Division of Aging Biology, Bethesda, Maryland, USA

    Ronald Kohanski

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Fillingim, R.B., Turk, D.C., Yezierski, R.P. (2016). Pain in the Elderly. In: Sierra, F., Kohanski, R. (eds) Advances in Geroscience. Springer, Cham. https://doi.org/10.1007/978-3-319-23246-1_18

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