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Common Themes in the Pathogenesis of Neurodegeneration

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Neurodegenerative Disorders

Abstract

Neurodegenerative diseases share a number of common features with respect to clinical course, pathology, and molecular mechanisms. This chapter outlines the common themes of neurodegeneration, including the concept of selective neuronal vulnerability, genetic susceptibility, aberrant protein structures, disruption in mitochondrial function, altered axonal transport,oxidative stress, dysregulated RNA processing and neuroinflammation. A greater understanding of the shared pathophysiologic processes for neurodegenerative diseases will help to develop therapeutic agents that may be beneficial to a range of different clinical phenotypes.

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Author information

Authors and Affiliations

  1. Trinity College Institute of Neuroscience, Lloyd Building, Trinity College, Dublin, Ireland

    Marina A. Lynch

  2. Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Dublin, Ireland

    Orla Hardiman & Marwa Elamin

  3. Department Neurology, Sheffield Institute of Translational Neuroscience, Sheffield University, Sheffield, UK

    Janine Kirby

  4. Department Neurology, New York Institute of Neurology, Columbia University Medical Center, New York, NY, USA

    Lewis P. Rowland

Authors
  1. Marina A. Lynch
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  2. Orla Hardiman
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  3. Marwa Elamin
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  4. Janine Kirby
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  5. Lewis P. Rowland
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Corresponding author

Correspondence to Marina A. Lynch .

Editor information

Editors and Affiliations

  1. Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Dublin, Ireland

    Orla Hardiman

  2. Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Dublin, Ireland

    Colin P. Doherty

  3. Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Dublin, Ireland

    Marwa Elamin

  4. Academic Unit of Neurology, Trinity Biomedical Sciences Inst, Dublin, Ireland

    Peter Bede

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Lynch, M.A., Hardiman, O., Elamin, M., Kirby, J., Rowland, L.P. (2016). Common Themes in the Pathogenesis of Neurodegeneration. In: Hardiman, O., Doherty, C., Elamin, M., Bede, P. (eds) Neurodegenerative Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-23309-3_1

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  • DOI: https://doi.org/10.1007/978-3-319-23309-3_1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-23308-6

  • Online ISBN: 978-3-319-23309-3

  • eBook Packages: MedicineMedicine (R0)

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