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History and Current Status of Online Haemodiafiltration

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Hemodiafiltration

Abstract

The genesis of hemodiafiltration (HDF) has followed the general sequence of any new therapy passing through a conceptual phase, a development phase and a long-term evaluation phase with adequate analysis in each step.

In the conceptual phase unmet needs of end stage kidney disease patients treated by hemodialysis were identified, proof of concept was established and the necessary technological development took place.

During the development phase short-term clinical studies demonstrated the safety and efficacy of the online HDF and long-term clinical studies gave evidence of benefits and risks of this new renal replacement modality.

After having satisfied these different steps, any remaining questions and/or uncertainties can be formulated and the future of the therapy can be discussed. In these entire phases one can identify key discoveries and applications that have contributed to major steps forward, often in a new direction.

In this chapter, we have highlighted such events and discussed their importance.

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Authors and Affiliations

  1. Nephrology, Center of Excellence Medical, Fresenius Medical Care Deutschland GmbH, Else-Kröner-Straße 1, Bad Homburg v.d.H., 61352, Germany

    Bernard Canaud PhD (Emeritus Professor)

  2. University of Montpellier, School of Medicine, Montpellier, France

    Bernard Canaud PhD (Emeritus Professor)

  3. Scientific Support Gambro 1980–2012, Lund, Sweden

    Ingrid Ledebo PhD (Director)

Authors
  1. Bernard Canaud PhD
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  2. Ingrid Ledebo PhD
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Correspondence to Bernard Canaud PhD .

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Editors and Affiliations

  1. Department of Nephrology, VU University Medical Centre, Amsterdam, The Netherlands

    Menso J. Nubé

  2. Department of Nephrology, VU University Medical Center, Amsterdam, The Netherlands

    Muriel P.C. Grooteman

  3. Department of Nephrology, University Medical Center Utrecht, Utrecht, The Netherlands

    Peter J. Blankestijn

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© 2016 Springer International Publishing Switzerland

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Canaud, B., Ledebo, I. (2016). History and Current Status of Online Haemodiafiltration. In: Nubé, M., Grooteman, M., Blankestijn, P. (eds) Hemodiafiltration. Springer, Cham. https://doi.org/10.1007/978-3-319-23332-1_1

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  • DOI: https://doi.org/10.1007/978-3-319-23332-1_1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-23331-4

  • Online ISBN: 978-3-319-23332-1

  • eBook Packages: MedicineMedicine (R0)

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