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Epidemiology of Systemic Lupus Erythematosus

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Connective Tissue Disease

Part of the book series: Rare Diseases of the Immune System ((RDIS))

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Abstract

Systemic lupus erythematosus (SLE) is a severe autoimmune rheumatic disease of unclear etiology that affects people worldwide. SLE presents with a wide spectrum of clinical patterns and can affect people of all ages and ethnicities. Regardless of age at disease onset, the diagnosis relies upon a combination of clinical and laboratory findings which are dealt with in greater detail in other sections of the book. According to the most recent revision of the literature, incidence rates of SLE range from approximately 1 to 10 per 100,000 person-years, and prevalence rates generally range from 20 to 70 per 100,000. Even if SLE occurs throughout the world, many variables such as ethnicity, geography, sex, and age affect the epidemiology of SLE. In this chapter we aim to critically review the epidemiology of SLE.

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References

  1. Tsokos GC (2011) Systemic lupus erythematosus. N Engl J Med 365(22):2110–2121. doi:10.1056/NEJMra1100359

    Article  CAS  PubMed  Google Scholar 

  2. Tan EM, Cohen AS, Fries JF et al (1982) The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25(11):1271–1277, http://www.ncbi.nlm.nih.gov/pubmed/7138600. Accessed 13 May 2015

    Article  CAS  PubMed  Google Scholar 

  3. Levin RE, Weinstein A, Peterson M et al (1984) A comparison of the sensitivity of the 1971 and 1982 American Rheumatism Association criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 27(5):530–538, http://www.ncbi.nlm.nih.gov/pubmed/6721885. Accessed 13 May 2015

    Article  CAS  PubMed  Google Scholar 

  4. Passas CM, Wong RL, Peterson M et al (1985) A comparison of the specificity of the 1971 and 1982 American Rheumatism Association criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 28(6):620–623, http://www.ncbi.nlm.nih.gov/pubmed/4004972. Accessed 13 May 2015

    Article  CAS  PubMed  Google Scholar 

  5. Petri M (2005) Review of classification criteria for systemic lupus erythematosus. Rheum Dis Clin N Am 31(2):245–254, vi. doi:10.1016/j.rdc.2005.01.009

    Article  Google Scholar 

  6. Petri M, Orbai A-M, Alarcón GS et al (2012) Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum 64(8):2677–2686. doi:10.1002/art.34473

    Article  PubMed  PubMed Central  Google Scholar 

  7. Uramoto KM, Michet CJ, Thumboo J et al (1999) Trends in the incidence and mortality of systemic lupus erythematosus, 1950–1992. Arthritis Rheum 42(1):46–50. doi:10.1002/1529-0131(199901)42:1<46::AID-ANR6>3.0.CO;2-2

    Article  CAS  PubMed  Google Scholar 

  8. Voss A, Green A, Junker P (1998) Systemic lupus erythematosus in Denmark: clinical and epidemiological characterization of a county-based cohort. Scand J Rheumatol 27(2):98–105, http://www.ncbi.nlm.nih.gov/pubmed/9572634. Accessed 23 May 2015

    Article  CAS  PubMed  Google Scholar 

  9. Johnson AE, Gordon C, Hobbs FD et al (1996) Undiagnosed systemic lupus erythematosus in the community. Lancet 347(8998):367–369, http://www.ncbi.nlm.nih.gov/pubmed/8598703. Accessed 23 May 2015

    Article  CAS  PubMed  Google Scholar 

  10. Geva E, Lerner-Geva L, Burke M et al (2004) Undiagnosed systemic lupus erythematosus in a cohort of infertile women. Am J Reprod Immunol 51(5):336–340. doi:10.1111/j.1600-0897.2004.00165.x

    Article  PubMed  Google Scholar 

  11. Somers EC, Marder W, Cagnoli P et al (2014) Population-based incidence and prevalence of systemic lupus erythematosus: the Michigan Lupus Epidemiology and Surveillance program. Arthritis Rheumatol (Hoboken NJ) 66(2):369–378. doi:10.1002/art.38238

    Article  Google Scholar 

  12. Pons-Estel GJ, Alarcon GS, Scofield L et al (2010) Understanding the epidemiology and progression of systemic lupus erythematosus. Semin Arthritis Rheum 39(4):257–268. doi:10.1016/j.semarthrit.2008.10.007

    Article  PubMed  PubMed Central  Google Scholar 

  13. Osio-Salido E, Manapat-Reyes H (2010) Epidemiology of systemic lupus erythematosus in Asia. Lupus 19(12):1365–1373. doi:10.1177/0961203310374305

    Article  CAS  PubMed  Google Scholar 

  14. Mok CC (2011) Epidemiology and survival of systemic lupus erythematosus in Hong Kong Chinese. Lupus 20(7):767–771. doi:10.1177/0961203310388447

    Article  CAS  PubMed  Google Scholar 

  15. Barnabe C, Joseph L, Belisle P et al (2012) Prevalence of systemic lupus erythematosus and systemic sclerosis in the First Nations population of Alberta, Canada. Arthritis Care Res (Hoboken) 64(1):138–143. doi:10.1002/acr.20656

    Article  Google Scholar 

  16. Furst DE, Clarke AE, Fernandes AW et al (2013) Incidence and prevalence of adult systemic lupus erythematosus in a large US managed-care population. Lupus 22(1):99–105. doi:10.1177/0961203312463110

    Article  CAS  PubMed  Google Scholar 

  17. Ng R, Bernatsky S, Rahme E (2013) Observation period effects on estimation of systemic lupus erythematosus incidence and prevalence in Quebec. J Rheumatol 40(8):1334–1336. doi:10.3899/jrheum.121215

    Article  PubMed  Google Scholar 

  18. Shim J-S, Sung Y-K, Joo YB et al (2014) Prevalence and incidence of systemic lupus erythematosus in South Korea. Rheumatol Int 34(7):909–917

    Article  PubMed  Google Scholar 

  19. Lim SS, Bayakly AR, Helmick CG et al (2014) The incidence and prevalence of systemic lupus erythematosus, 2002–2004: the Georgia Lupus Registry. Arthritis Rheumatol (Hoboken NJ) 66(2):357–368. doi:10.1002/art.38239

    Article  Google Scholar 

  20. Zou Y-F, Feng C-C, Zhu J-M et al (2014) Prevalence of systemic lupus erythematosus and risk factors in rural areas of Anhui Province. Rheumatol Int 34(3):347–356. doi:10.1007/s00296-013-2902-1

    Article  PubMed  Google Scholar 

  21. Simard JF, Sjowall C, Ronnblom L et al (2014) Systemic lupus erythematosus prevalence in Sweden in 2010: what do national registers say? Arthritis Care Res (Hoboken) 66(11):1710–1717. doi:10.1002/acr.22355

    Article  Google Scholar 

  22. Arnaud L, Fagot J-P, Mathian A et al (2014) Prevalence and incidence of systemic lupus erythematosus in France: a 2010 nation-wide population-based study. Autoimmun Rev 13(11):1082–1089. doi:10.1016/j.autrev.2014.08.034

    Article  PubMed  Google Scholar 

  23. Ferucci ED, Johnston JM, Gaddy JR et al (2014) Prevalence and incidence of systemic lupus erythematosus in a population-based registry of American Indian and Alaska Native people, 2007–2009. Arthritis Rheumatol (Hoboken NJ) 66(9):2494–2502. doi:10.1002/art.38720

    Article  Google Scholar 

  24. Rees F, Doherty M, Grainge M et al (2014) The incidence and prevalence of systemic lupus erythematosus in the UK, 1999–2012. Ann Rheum Dis. doi:10.1136/annrheumdis-2014-206334

    PubMed  PubMed Central  Google Scholar 

  25. Nikpour M, Bridge JA, Richter S (2014) A systematic review of prevalence, disease characteristics and management of systemic lupus erythematosus in Australia: identifying areas of unmet need. Intern Med J 44(12a):1170–1179. doi:10.1111/imj.12568

    Article  CAS  PubMed  Google Scholar 

  26. Ju JH, Yoon S-H, Kang KY et al (2014) Prevalence of systemic lupus erythematosus in South Korea: an administrative database study. J Epidemiol 24(4):295–303

    Article  PubMed  PubMed Central  Google Scholar 

  27. Nasonov E, Soloviev S, Davidson JE et al (2014) The prevalence and incidence of systemic lupus erythematosus (SLE) in selected cities from three Commonwealth of Independent States countries (the Russian Federation, Ukraine and Kazakhstan). Lupus 23(2):213–219. doi:10.1177/0961203313512881

    Article  CAS  PubMed  Google Scholar 

  28. Jarukitsopa S, Hoganson DD, Crowson CS et al (2014) Epidemiology of systemic lupus erythematosus and cutaneous lupus in a predominantly white population in the United States. Arthritis Care Res (Hoboken). doi:10.1002/acr.22502

    Google Scholar 

  29. Brinks R, Fischer-Betz R, Sander O et al (2014) Age-specific prevalence of diagnosed systemic lupus erythematosus in Germany 2002 and projection to 2030. Lupus 23(13):1407–1411. doi:10.1177/0961203314540352

    Article  CAS  PubMed  Google Scholar 

  30. Housey M, DeGuire P, Lyon-Callo S et al (2015) Incidence and prevalence of systemic lupus erythematosus among Arab and Chaldean Americans in southeastern Michigan: the Michigan Lupus Epidemiology and Surveillance Program. Am J Public Health 105(5):e74–e79. doi:10.2105/AJPH.2014.302423

    Article  PubMed  Google Scholar 

  31. Urowitz MB, Gladman DD, Tom BDM et al (2008) Changing patterns in mortality and disease outcomes for patients with systemic lupus erythematosus. J Rheumatol 35(11):2152–2158

    Article  PubMed  Google Scholar 

  32. Ståhl-Hallengren C, Jönsen A, Nived O et al (2000) Incidence studies of systemic lupus erythematosus in Southern Sweden: increasing age, decreasing frequency of renal manifestations and good prognosis. J Rheumatol 27(3):685–691, http://www.ncbi.nlm.nih.gov/pubmed/10743809. Accessed 23 May 2015

    PubMed  Google Scholar 

  33. Molina MJ, Mayor AM, Franco AE et al (2007) Prevalence of systemic lupus erythematosus and associated comorbidities in Puerto Rico. J Clin Rheumatol 13(4):202–204. doi:10.1097/RHU.0b013e318124a8af

    Article  PubMed  PubMed Central  Google Scholar 

  34. Deng Y, Tsao BP (2014) Advances in lupus genetics and epigenetics. Curr Opin Rheumatol 26(5):1–11. doi:10.1097/BOR.0000000000000086

    Article  Google Scholar 

  35. Wang J, Yang S, Chen JJ et al (2007) Systemic lupus erythematosus: a genetic epidemiology study of 695 patients from China. Arch Dermatol Res 298(10):485–491. doi:10.1007/s00403-006-0719-4

    Article  CAS  PubMed  Google Scholar 

  36. Simard JF, Costenbader KH (2007) What can epidemiology tell us about systemic lupus erythematosus? Int J Clin Pract 61(7):1170–1180. doi:10.1111/j.1742-1241.2007.01434.x

    Article  CAS  PubMed  Google Scholar 

  37. Deng Y, Tsao BP (2011) Genetic susceptibility to systemic lupus erythematosus in the genomic era. Nat Rev Rheumatol 6(12):683–692. doi:10.1038/nrrheum.2010.176.Genetic

    Article  Google Scholar 

  38. Kamphuis S, Silverman ED (2010) Prevalence and burden of pediatric-onset systemic lupus erythematosus. Nat Rev Rheumatol 6(9):538–546. doi:10.1038/nrrheum.2010.121

    Article  CAS  PubMed  Google Scholar 

  39. Arnaud L, Mathian A, Boddaert J et al (2012) Late-onset systemic lupus erythematosus: epidemiology, diagnosis and treatment. Drugs Aging 29(3):181–189. doi:10.2165/11598550-000000000-00000

    Article  CAS  PubMed  Google Scholar 

  40. Costenbader KH, Kim DJ, Peerzada J et al (2004) Cigarette smoking and the risk of systemic lupus erythematosus: a meta-analysis. Arthritis Rheum 50(3):849–857. doi:10.1002/art.20049

    Article  PubMed  Google Scholar 

  41. Mak A, Tay S (2014) Environmental factors, toxicants and systemic lupus erythematosus. Int J Mol Sci 15(9):16043–16056. doi:10.3390/ijms150916043

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Wang J, Pan H-F, Ye D-Q et al (2008) Moderate alcohol drinking might be protective for systemic lupus erythematosus: a systematic review and meta-analysis. Clin Rheumatol 27(12):1557–1563. doi:10.1007/s10067-008-1004-z

    Article  PubMed  Google Scholar 

  43. Postal M, Appenzeller S (2011) The role of Tumor Necrosis Factor-alpha (TNF-α) in the pathogenesis of systemic lupus erythematosus. Cytokine 56(3):537–543. doi:10.1016/j.cyto.2011.08.026

    Google Scholar 

  44. McGarvey PB, Suzek BE, Baraniuk JN et al (2014) In silico analysis of autoimmune diseases and genetic relationships to vaccination against infectious diseases. BMC Immunol 15(1):1–12. doi:10.1186/s12865-014-0061-0

    Article  Google Scholar 

  45. Qian G, Ran X, Zhou CX et al (2014) Systemic lupus erythematosus patients in the low-latitude plateau of China: altitudinal influences. Lupus 23(14):1537–1545. doi:10.1177/0961203314544186

    Article  CAS  PubMed  Google Scholar 

  46. Leffler J, Bengtsson AA, Blom AM (2014) The complement system in systemic lupus erythematosus: an update. Ann Rheum Dis 73(9):1601–1606. doi:10.1136/annrheumdis-2014-205287

    Article  CAS  PubMed  Google Scholar 

  47. Chen Y-M, Lin C-HC-H, Chen H-H et al (2013) Onset age affects mortality and renal outcome of female systemic lupus erythematosus patients: a nationwide population-based study in Taiwan. Rheumatology 53(1):180–185. doi:10.1093/rheumatology/ket330

    Article  PubMed  Google Scholar 

  48. Petri M, Bello KJ, Fang H et al (2013) Vitamin D in systemic lupus erythematosus: modest association with disease activity and the urine protein-to-creatinine ratio. Arthritis Rheum 65(7):1865–1871. doi:10.1002/art.37953

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Saxena R, Mahajan T, Mohan C (2011) Lupus nephritis: current update. Arthritis Res Ther 13:240–252

    Article  PubMed  PubMed Central  Google Scholar 

  50. Seligman VA, Lum RF, Olson JL, et al (2002) Demographic differences in the development of lupus nephritis: a retrospective analysis. Am J Med 112:726–729

    Article  PubMed  Google Scholar 

  51. Mak A, Mok CC, Chu WP et al (2007) Renal damage in systemic lupus erythematosus: a comparative analysis of different age groups. Lupus 16:28–34

    Article  CAS  PubMed  Google Scholar 

  52. Weening JJ, D’Agati VD, Schwartz MM et al (2004) The classification of glomerulonephritis in systemic lupus erythematosus revisited. Am J Kidney Dis 15:241–250

    Google Scholar 

  53. Wakasugi D, Gono T, Kawaguchi Y et al (2012) Frequency of class III and IV nephritis in systemic lupus erythematosus without clinical renal involvement: an analysis of predictive measures. J Rheumatol 39:79

    Article  CAS  PubMed  Google Scholar 

  54. Osler W (1904) On the visceral manifestations of the erythema group of skin diseases. Am J Med Sci 127:1–23

    Article  Google Scholar 

  55. Maroz N, Segal MS (2013) Lupus nephritis and end-stage kidney disease. Am J Med Sci 346:319–323

    Article  PubMed  Google Scholar 

  56. Jarrett M, Santhanam S, Del Greco F (1983) The clinical course of endstage renal disease in systemic lupus erythematosus. Arch Intern Med 143:1353–1356

    Article  CAS  PubMed  Google Scholar 

  57. Cervera R, Khamashta M, Hughes G (2009) The Euro-lupus project: epidemiology of systemic lupus erythematosus in Europe. Lupus 18:869–874

    Article  CAS  PubMed  Google Scholar 

  58. Mojcik C, Klippel J (1996) End-stage renal disease and systemic lupus erythematosus. Am J Med 101:100–107

    Article  CAS  PubMed  Google Scholar 

  59. Ward MM (2009) Changes in the incidence of endstage renal disease due to lupus nephritis in the United States, 1996–2004. J Rheumatol 36:63–67

    PubMed  PubMed Central  Google Scholar 

  60. Ward MM (2000) Changes in the incidence of end-stage renal disease due to lupus nephritis, 1982–1995. Arch Intern Med 160:3136–3140

    Article  CAS  PubMed  Google Scholar 

  61. Patel M, Clarke AM, Bruce IN et al (2006) The prevalence and incidence of biopsy-proven lupus nephritis in the UK: evidence of an ethnic gradient. Arthritis Rheum 54:2963–2969

    Google Scholar 

  62. Feldman CH, Hiraki LT, Liu J et al (2013) Epidemiology and sociodemographics of systemic lupus erythematosus and lupus nephritis among U.S. adults with Medicaid coverage, 2000–2004. Arthritis Rheum 65:753–763

    Google Scholar 

  63. Iseki K, Miyasato F, Oura T et al (1994) An epidemiologic analysis of end-stage lupus nephritis. Am J Kidney Dis 23:547–554

    Article  CAS  PubMed  Google Scholar 

  64. Andrade RM, Alarcon GS, Fernandez S et al LUMINA Study Group (2007) Accelerated damage accrual among men with systemic lupus erythematosus: XLIV. Results from a multiethnic US cohort. Arthritis Rheum 56:622–630

    Google Scholar 

  65. Chen HA, Wang JJ, Chou CT et al (2011) Predictors of long term mortality in patients with and without systemic lupus erythematosus on maintenance dialysis: a comparative study. J Rheumatol 38:2390–2394

    Article  PubMed  Google Scholar 

  66. McCarty DJ, Manzi S, Medsger TA Jr et al (1995) Incidence of systemic lupus erythematosus: race and gender differences. Arthritis Rheum 38:1260–1270

    Google Scholar 

  67. Bastian HM, Roseman JM, McGwin G Jr et al (2002) Systemic lupus erythematosus in three ethnic groups. XII. Risk factors for lupus nephritis after diagnosis. Lupus 11:152–160

    Article  CAS  PubMed  Google Scholar 

  68. Costenbader K, Desai A, Alarcon G et al (2011) Trends in the incidence, demographics, and outcomes of end-stage renal disease due to lupusnephritis in the US from 1995 to 2006. Arthritis Rheum 63:1681–1688

    Article  PubMed  PubMed Central  Google Scholar 

  69. Hiraki L, Lu B, Alexander S et al (2011) End-stage renal disease due to lupus nephritis among children in the US, 1995–2006. Arthritis Rheum 63:1988–1997

    Article  PubMed  PubMed Central  Google Scholar 

  70. Bartosh SM, Fine RN, Sullivan EK (2001) Outcome after transplantation of young patients with systemic lupus erythematosus: a report of the North American pediatric renal transplant cooperative study. Transplantation 72:973–978

    Article  CAS  PubMed  Google Scholar 

  71. Fiehn C, Hajjar Y, Mueller K et al (2003) Improved clinical outcome of lupus nephritis during the past decade: importance of early diagnosis and treatment. Ann Rheum Dis 62:435–439

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  72. Esdaile J, Levinton C, Federgreen W et al (1989) The clinical and renal biopsy predictors of long-term outcome in lupus nephritis: a study of 87 patients and review of the literature. Q J Med 72:779–833

    CAS  PubMed  Google Scholar 

  73. Sexton DJ, Reule S, Solid C et al (2015) ESKD from lupus nephritis in the United States, 1995–2010. Clin J Am Soc Nephrol 10:251–259

    Article  PubMed  PubMed Central  Google Scholar 

  74. Brentjens JR, Sepulveda M, Baliah T et al (1975) Interstitial immune complex nephritis in patients with systemic lupus erythematosus. Kidney Int 7:342

    Article  CAS  PubMed  Google Scholar 

  75. Park MH, D’Agati V, Appel GB et al (1986) Tubulointerstitial disease in lupus nephritis: relationship to immune deposits, interstitial inflammation, glomerular changes, renal function, and prognosis. Nephron 44:309

    Article  CAS  PubMed  Google Scholar 

  76. Yu F, Wu LH, Tan Y et al (2010) Tubulointerstitial lesions of patients with lupus nephritis classified by the 2003 International Society of Nephrology and Renal Pathology Society system. Kidney Int 77:820

    Article  PubMed  Google Scholar 

  77. Kozeny GA, Barr W, Bansal VK et al (1987) Occurrence of renal tubular dysfunction in lupus nephritis. Arch Intern Med 147:891

    Article  CAS  PubMed  Google Scholar 

  78. DeFronzo RA, Cooke CR, Goldberg M et al (1977) Impaired renal tubular potassium secretion in systemic lupus erythematosus. Ann Intern Med 86:268

    Article  CAS  PubMed  Google Scholar 

  79. Wu LH, Yu F, Tan Y et al (2013) Inclusion of renal vascular lesions in the 2003 ISN/RPS system for classifying lupus nephritis improves renal outcome predictions. Kidney Int 83:715

    Article  CAS  PubMed  Google Scholar 

  80. Kwok SK, Ju JH, Cho CS et al (2009) Thrombotic thrombocytopenic purpura in systemic lupus erythematosus: risk factors and clinical outcome: a single centre study. Lupus 18:16

    Article  CAS  PubMed  Google Scholar 

  81. Song D, Wu LH, Wang FM et al (2013) The spectrum of renal thrombotic microangiopathy in lupus nephritis. Arthritis Res Ther 15:R12

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  82. Abdellatif AA, Waris S, Lakhani A et al (2010) True vasculitis in lupus nephritis. Clin Nephrol 74:106

    Article  CAS  PubMed  Google Scholar 

  83. Gelfand J, Truong L, Stern L et al (1985) Thrombotic thrombocytopenic purpura syndrome in systemic lupus erythematosus: treatment with plasma infusion. Am J Kidney Dis 6:154

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Center of Research of Immunopathology and Rare Diseases, Coordinating Center of the Network of Rare Diseases of Piedmont and Aosta Valley, Department of Rare, Immunologic, Hematologic and Immunohematologic Diseases, San Giovanni Hospital, Piazza donatore di Sangue 3, Turin, 10154, Italy

    Simone Baldovino

  2. SCDU Nephrology and Dialysis, San Giovanni Hospital, Piazza donatore di Sangue 3, Turin, 10154, Italy

    Cristiana Rollino

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  1. Simone Baldovino
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  1. Giovanni Bosco Hospital, Center of Immunopathology/Rare Dise, Torino, Torino, Italy

    Dario Roccatello

  2. University of Florence, Florence, Italy

    Lorenzo Emmi

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Baldovino, S., Rollino, C. (2016). Epidemiology of Systemic Lupus Erythematosus. In: Roccatello, D., Emmi, L. (eds) Connective Tissue Disease. Rare Diseases of the Immune System. Springer, Cham. https://doi.org/10.1007/978-3-319-24535-5_2

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