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Development of Neural Activity in the Enteric Nervous System: Similarities and Differences to Other Parts of the Nervous System

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The Enteric Nervous System

Part of the book series: Advances in Experimental Medicine and Biology ((ANS,volume 891))

Abstract

All the neurons and glia of the enteric nervous system (ENS) arise from neural crest-derived cells that migrate into the gastrointestinal (GI) tract during development (Yntema and Hammond 1954; Le Douarin and Teillet 1973). Most of the ENS originates from vagal neural crest cells (NCCs), which arise from the caudal hindbrain region of the neural tube, adjacent to somites 1–7. In the developing mouse, vagal NCCs migrate into the developing oesophagus and stomach at embryonic day (E)9.5, enter the small intestine at E10.5, and colonise the developing GI tract in a rostral-to-caudal wave, reaching the anal end of the colon at E14.5 (Serbedzija et al. 1991; Kapur et al. 1992; Anderson et al. 2006). Recent evidence indicates that there is also trans-mesenteric migration of vagal NCCs, where some NCCs leave the small intestine and migrate directly across the mesentery into the colon (Nishiyama et al. 2012). Sacral NCCs also contribute to a small population of neurons and glia in the colon (Burns and Le Douarin 1998; Wang et al. 2011).

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Authors and Affiliations

  1. Laboratory for Enteric Neuroscience, TARGID, University of Leuven, Herestraat 49, O&N1, Box 701, Leuven, 3000, Belgium

    Marlene M. Hao

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  1. Marlene M. Hao
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Correspondence to Marlene M. Hao .

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Editors and Affiliations

  1. Discipline of Medicine, University of Adelaide, Adelaide, South Australia, Australia

    Stuart Brierley

  2. Department of Human Physiology, School of Medicine, Flinders University,, Adelaide, South Australia, Australia

    Marcello Costa

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M. Hao, M. (2016). Development of Neural Activity in the Enteric Nervous System: Similarities and Differences to Other Parts of the Nervous System. In: Brierley, S., Costa, M. (eds) The Enteric Nervous System. Advances in Experimental Medicine and Biology(), vol 891. Springer, Cham. https://doi.org/10.1007/978-3-319-27592-5_5

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