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Neutrophils, Inflammation, and Innate Immunity in Trauma-Induced Coagulopathy

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Trauma Induced Coagulopathy

Abstract

Neutrophils are the primary innate immune cell involved in acute inflammatory responses to trauma and injury. While the mechanisms used by neutrophils to cause inflammation are designed to protect the host and allow for recovery, many of these same processes can have pathologic outcomes, including the development of trauma-induced coagulopathy. Neutrophil priming, ROS production, degranulation, NETosis, and responses to damage-associated molecular patterns and how these phenomena drive interactions of the neutrophil with other host tissues and cells such as the endothelium will be reviewed here in the context of major trauma and the resulting development of coagulopathy and end-organ damage. Although neutrophil biology and innate immunity is an expansive topic, the goal of this chapter is to provide the reader with a broad understanding of neutrophil function focused within the context of trauma and trauma-induced coagulopathy.

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Acknowledgements

This work was funded by NIH grant R01-GM52981 and UM1-HL120877. We gratefully acknowledge contributions from our long-standing colleagues Glenn Brown, Mary Stewart, Chris Ellson, and Albert Hsu, our illustrator Iris Fung, and very helpful discussions with our collaborator Jamel El-Benna.

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Authors and Affiliations

  1. Division of Trauma and Critical Care, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

    Christopher D. Barrett M.D. & Michael B. Yaffe M.D., Ph.D.

  2. Departments of Biological Engineering and Biology, Koch Institute for Integrative Cancer Biology, Massachusetts Institute of Technology, Boston, MA, USA

    Michael B. Yaffe M.D., Ph.D.

  3. David H. Koch Institute for Integrative Cancer Research, 500 Main St., Room 76-353, Cambridge, MA, 02139, USA

    Michael B. Yaffe M.D., Ph.D.

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  1. Christopher D. Barrett M.D.
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Correspondence to Michael B. Yaffe M.D., Ph.D. .

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Editors and Affiliations

  1. Dept of Surgery & Trauma Research Center, Univ of Colorado School of Medicine, Aurora, Colorado, USA

    Eduardo Gonzalez

  2. Dept of Surgery & Trauma Research Center, Univ of Colorado School of Medicine, Aurora, Colorado, USA

    Hunter B. Moore

  3. Dept of Surgery & Trauma Research Center, Univ of Colorado Sch of Med&Denver Healt, Denver, Colorado, USA

    Ernest E. Moore

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Barrett, C.D., Yaffe, M.B. (2016). Neutrophils, Inflammation, and Innate Immunity in Trauma-Induced Coagulopathy. In: Gonzalez, E., Moore, H., Moore, E. (eds) Trauma Induced Coagulopathy. Springer, Cham. https://doi.org/10.1007/978-3-319-28308-1_10

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