Skip to main content

Differential Diagnosis of Upper Extremity Ischemia

  • Chapter
  • First Online:
Critical Limb Ischemia

Abstract

Upper extremity ischemia occurs as a consequence of occlusive, embolic, or vasospastic events and occurs in the context of a wide range of associated atherosclerotic and non-atherosclerotic conditions. Classification of the wide range of causes for upper extremity ischemia is challenging but is best approached by assessing the etiology, anatomic location, and size of the affected arteries. The careful consideration of patient history, clinical evaluation, and physical examination with selective radiologic imaging can help the clinician pinpoint the underlying causes for ischemia as well as direct subsequent treatment. In this chapter, the authors will provide an overview of the causes of acute and chronic upper extremity arterial ischemia as well as outline the appropriate steps for clinical diagnostic evaluation. The diagnostic imaging modalities available for patient assessment are reviewed, and a brief discussion of the medical, surgical, and endovascular options for treatment of patients with upper extremity ischemia are outlined. This chapter will provide the clinician with the fundamentals allowing a systematic approach to the evaluation of patients and making an accurate diagnosis for the majority of patients with upper extremity ischemia.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Bornfeldt KE. 2013 Russell Ross memorial lecture in vascular biology: cellular and molecular mechanisms of diabetes mellitus-accelerated atherosclerosis. Arterioscler Thromb Vasc Biol. 2014;34:705–14.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Appelman Y, van Rijn BB, Ten Haaf ME, Boersma E, Peters SA. Sex differences in cardiovascular risk factors and disease prevention. Atherosclerosis. 2015;241:211–8.

    Article  CAS  PubMed  Google Scholar 

  3. Moreno G, Mangione CM. Management of cardiovascular disease risk factors in older adults with type 2 diabetes mellitus: 2002–2012 literature review. J Am Geriatr Soc. 2013;61:2027–37.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Mishima Y. Arterial insufficiency of the upper extremity with special reference to Takayasu’s arteritis and Buerger’s disease. J Cardiovasc Surg (Torino). 1982;23:105–8.

    CAS  Google Scholar 

  5. Mills Sr JL. Buerger’s disease in the 21st century: diagnosis, clinical features, and therapy. Semin Vasc Surg. 2003;16:179–89.

    Article  PubMed  Google Scholar 

  6. Tan TW, Kenney R, Farber A. Left arterial thoracic outlet syndrome. Texas Heart Inst J. 2014;41:105–6.

    Article  CAS  Google Scholar 

  7. Durham JR, Yao JS, Pearce WH, Nuber GM, McCarthy 3rd WJ. Arterial injuries in the thoracic outlet syndrome. J Vasc Surg. 1995;21:57–69. discussion 70.

    Article  CAS  PubMed  Google Scholar 

  8. Kolluri R, Ansel G. Fibromuscular dysplasia of bilateral brachial arteries--a case report and literature review. Angiology. 2004;55:685–9.

    Article  PubMed  Google Scholar 

  9. Reilly JM, McGraw DJ, Sicard GA. Bilateral brachial artery fibromuscular dysplasia. Ann Vasc Surg. 1993;7:483–7.

    Article  CAS  PubMed  Google Scholar 

  10. Weaver FA, Yellin AE, Campen DH, Oberg J, Foran J, Kitridou RC, Lee SE, Kohl RD. Surgical procedures in the management of Takayasu’s arteritis. J Vasc Surg. 1990;12:429–37. discussion 438–429.

    Article  CAS  PubMed  Google Scholar 

  11. Coffman JD. Raynaud’s phenomenon. Curr Treat Opt Cardiovasc Med. 2000;2:219–26.

    Article  Google Scholar 

  12. Kallenberg CG, Wouda AA, Hoet MH, van Venrooij WJ. Development of connective tissue disease in patients presenting with Raynaud’s phenomenon: a six year follow up with emphasis on the predictive value of antinuclear antibodies as detected by immunoblotting. Ann Rheum Dis. 1988;47:634–41.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Herrick AL. Pathogenesis of Raynaud’s phenomenon. Rheumatology (Oxford). 2005;44:587–96.

    Article  CAS  Google Scholar 

  14. Carter PM, Hollinshead PA, Desmond JS. Hypothenar hammer syndrome: case report and review. J Emerg Med. 2013;45:22–5.

    Article  PubMed  Google Scholar 

  15. Ablett CT, Hackett LA. Hypothenar hammer syndrome: case reports and brief review. Clin Med Res. 2008;6:3–8.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Swanson KE, Bartholomew JR, Paulson R. Hypothenar hammer syndrome: a case and brief review. Vasc Med. 2012;17:108–15.

    Article  PubMed  Google Scholar 

  17. Jousse-Joulin S, Plat E, Guias B, D’Agostino A, Bressollette ML, Saraux A. Bilateral thenar hammer syndrome. Joint Bone Spine. 2011;78:212–4.

    Article  PubMed  Google Scholar 

  18. Kim MD, Lee G, Shin SW. Ergotamine-induced upper extremity ischemia: a case report. Kor J Radiol. 2005;6:130–2.

    Article  Google Scholar 

  19. Mills JL, Friedman EI, Taylor Jr LM, Porter JM. Upper extremity ischemia caused by small artery disease. Ann Surg. 1987;206:521–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Agency for Toxic Substances and Disease Registry, Vinyl Chloride. In: Toxic Substances, Agency for Toxic Substances and Disease Registry, Atlanta, FA, 2011.

    Google Scholar 

  21. Doll DC, Ringenberg QS, Yarbro JW. Vascular toxicity associated with antineoplastic agents. J Clin Oncol. 1986;4:1405–17.

    CAS  PubMed  Google Scholar 

  22. Yamaguchi S, Viegas SF. Causes of upper extremity compartment syndrome. Hand Clin. 1998;14:365–70. viii.

    CAS  PubMed  Google Scholar 

  23. Ibey A. Pediatric compartment syndrome caused by intravenous infiltration. Ann Plast Surg. 2012;69:340.

    Article  CAS  PubMed  Google Scholar 

  24. Schmit BM, Freshwater MF. Pediatric infiltration injury and compartment syndrome. J Craniofac Surg. 2009;20:1021–4.

    Article  PubMed  Google Scholar 

  25. O.M. Loubani, R.S. Green, A systematic review of extravasation and local tissue injury from administration of vasopressors through peripheral intravenous catheters and central venous catheters. J Crit Care 2015;30:653.e9–17

    Google Scholar 

  26. Cowen R, Richards T, Dharmadasa A, Handa A, Perkins JM. The acute blue finger: management and outcome. Ann R Coll Surg Engl. 2008;90:557–60.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Hill RD, Smith RB, Examination of the extremities: pulses, bruits, and phlebitis. In: Walker HK, Hall WD, Hurst JW, editors. Clinical methods: the history, physical, and laboratory examinations. Boston: Butterworth Publishers; 1990.

    Google Scholar 

  28. Bickley L, Szilagyi PG. Peripheral vascular system: techniques of examination, bates’ guide to physical examination and history-taking. Philadelphia: Wolters Kluwer Health; 2013. p. 481–2.

    Google Scholar 

  29. Demondion X, Vidal C, Herbinet P, Gautier C, Duquesnoy B, Cotten A. Ultrasonographic assessment of arterial cross-sectional area in the thoracic outlet on postural maneuvers measured with power Doppler ultrasonography in both asymptomatic and symptomatic populations. J Ultrasound Med. 2006;25:217–24.

    PubMed  Google Scholar 

  30. Stefanczyk L, Wozniakowski B, Pietrzak P, Majos A, Grzelak P. Comparison of thermography and Doppler sonography in the evaluation of the cold immersion test in women with excessive vasospastic reaction. Medical Sci Monit. 2007;13 Suppl 1:121–8.

    Google Scholar 

  31. Gossage JA, Ali T, Chambers J, Burnand KG. Peripheral arterial embolism: prevalence, outcome, and the role of echocardiography in management. Vasc Endovascular Surg. 2006;40:280–6.

    Article  CAS  PubMed  Google Scholar 

  32. Tofigh AM, Karvandi M, Coscas R. Current incidence of peripheral arterial embolism and role of echocardiography. Asian Cardiovasc Thorac Ann. 2008;16:439–43.

    Article  PubMed  Google Scholar 

  33. Lagattolla NR, Burnand KG, Stewart A. Role of transoesophageal echocardiography in determining the source of peripheral arterial embolism. Br J Surg. 1995;82:1651–4.

    Article  CAS  PubMed  Google Scholar 

  34. Anderson GB, Ashforth R, Steinke DE, Ferdinandy R, Findlay JM. CT angiography for the detection and characterization of carotid artery bifurcation disease. Stroke. 2000;31:2168–74.

    Article  CAS  PubMed  Google Scholar 

  35. McCarthy WJ, Flinn WR, Yao JS, Williams LR, Bergan JJ. Result of bypass grafting for upper limb ischemia. J Vasc Surg. 1986;3:741–6.

    Article  CAS  PubMed  Google Scholar 

  36. Henry LG, Blackwood JS, Conley JE, Bernhard VM. Ergotism. Arch Surg. 1975;110:929–32.

    Article  CAS  PubMed  Google Scholar 

  37. Schwartz GG, Olsson AG, Ezekowitz MD, Ganz P, Oliver MF, Waters D, Zeiher A, Chaitman BR, Leslie S, Stern T. I. Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering Study, Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study: a randomized controlled trial. JAMA. 2001;285:1711–8.

    Article  CAS  PubMed  Google Scholar 

  38. Kumbhani DJ, Steg PG, Cannon CP, Eagle KA, Smith Jr SC, Goto S, Ohman EM, Elbez Y, Sritara P, Baumgartner I, Banerjee S, Creager MA, Bhatt DL, Investigators RR. Statin therapy and long-term adverse limb outcomes in patients with peripheral artery disease: insights from the REACH registry. Eur Heart J. 2014;35:2864–72.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Suckow BD, Kraiss LW, Schanzer A, Stone DH, Kalish J, DeMartino RR, Cronenwett JL, Goodney, PP, Vascular Study Group of New England. Statin therapy after infrainguinal bypass surgery for critical limb ischemia is associated with improved 5-year survival. J Vasc Surg. 2014;61:126–33e1.

    Google Scholar 

  40. Baril DT, Patel VI, Judelson DR, Goodney PP, McPhee JT, Hevelone ND, Cronenwett JL, Schanzer A, Vascular Study Group of New England. Outcomes of lower extremity bypass performed for acute limb ischemia. J Vasc Surg 2013; 58:949–56.

    Google Scholar 

  41. Sen D, Rosenstein ED, Kramer N. ANCA-positive vasculitis associated with simvastatin/ezetimibe: expanding the spectrum of statin-induced autoimmunity? Int J Rheum Dis. 2010;13:e29–31.

    Article  PubMed  Google Scholar 

  42. Wheatley MJ, Marx MV. The use of intra-arterial urokinase in the management of hand ischemia secondary to palmar and digital arterial occlusion. Ann Plast Surg. 1996;37:356–62. discussion 362–353.

    Article  CAS  PubMed  Google Scholar 

  43. Casserly I, Kapadia S. Upper extremity intervention. In: Bhatt D, editor. Guide to peripheral and cerebrovascular intervention. London: Remedica; 2004.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Drudi, L., MacKenzie, K. (2017). Differential Diagnosis of Upper Extremity Ischemia. In: Dieter, R., Dieter, Jr, R., Dieter, III, R., Nanjundappa, A. (eds) Critical Limb Ischemia. Springer, Cham. https://doi.org/10.1007/978-3-319-31991-9_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-31991-9_10

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-31989-6

  • Online ISBN: 978-3-319-31991-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics