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Apoptosis in Cancer Cells

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Information Technologies in Medicine (ITiB 2016)

Part of the book series: Advances in Intelligent Systems and Computing ((AISC,volume 472))

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Abstract

Programmed cell death changes and loss of cell growth and anti-growth regulation signals may result in uncontrolled cell proliferation, disorganized tissue growth and tumor formation. Malignant solid tumors, i.e. lung and brain tumors, are one of the most common and the most serious diseases nowadays and therefore considered a major issue in modern medicine. Despite intensive progress in cancer research, the survival rate of patients with diagnosed malignant solid tumors hasn’t improved significantly. Radiotherapy and chemotherapy work predominantly by inducing apoptosis. The purpose of this article is to describe the role of apoptosis and to review currently known agents that allow induction of apoptosis in cancer cells. The identification of potential new targets for tumor treatment and processes in altered tumor cell metabolism is the challenging area of research. Recognizing the attributes of malignant tumor growth inhibition may help in the development of novel treatment strategies.

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Acknowledgments

This work was supported by Ministry of Health of the Slovak Republic under the contract MZ SR 2012/25-UKMA-2, by the project Competence Center for Research and Development in the Field of Diagnostics and Therapy of Oncological Diseases, ITMS: 26220220153 and by the project “Biomedical Center Martin” ITMS code: 26220220187, the project is co-financed from EU sources.

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Authors and Affiliations

  1. Jessenius Faculty of Medicine in Martin, Department of Molecular Medicine, Biomedical Center Martin, Comenius University in Bratislava, Martin, Slovakia

    Eva Blahovcová, Henrieta Škovierová, Ján Strnádel & Erika Halašová

  2. Jessenius Faculty of Medicine in Martin, Clinic of Surgery and Transplant Center, Comenius University in Bratislava, Martin, Slovakia

    Dušan Mištuna

  3. Jessenius Faculty of Medicine in Martin, Department of Medical Biology, Comenius University in Bratislava, Martin, Slovakia

    Erika Halašová

Authors
  1. Eva Blahovcová
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  2. Henrieta Škovierová
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  3. Ján Strnádel
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  4. Dušan Mištuna
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  5. Erika Halašová
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Corresponding author

Correspondence to Eva Blahovcová .

Editor information

Editors and Affiliations

  1. Fac of Biomed Engg, ul. Roosevelta 40, Silesian University of Technology, Gliwice, Poland

    Ewa Piętka

  2. Fac of Biomed Engg, ul. Roosevelta 40, Silesian University of Technology, Gliwice, Poland

    Pawel Badura

  3. Faculty of Biomedical Engineering, Silesian University of Technology, Gliwice, Poland

    Jacek Kawa

  4. Faculty of Biomedical Engineering, Silesian University of Technology, Gliwice, Poland

    Wojciech Wieclawek

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Blahovcová, E., Škovierová, H., Strnádel, J., Mištuna, D., Halašová, E. (2016). Apoptosis in Cancer Cells. In: Piętka, E., Badura, P., Kawa, J., Wieclawek, W. (eds) Information Technologies in Medicine. ITiB 2016. Advances in Intelligent Systems and Computing, vol 472. Springer, Cham. https://doi.org/10.1007/978-3-319-39904-1_18

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  • DOI: https://doi.org/10.1007/978-3-319-39904-1_18

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-39903-4

  • Online ISBN: 978-3-319-39904-1

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