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Analysis of MicroRNA and Transcription Factor Regulation

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Intelligent Computing Theories and Application (ICIC 2016)

Part of the book series: Lecture Notes in Computer Science ((LNISA,volume 9771))

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Abstract

Gene regulatory networks in different tissues offer insight into the mechanism of tissue identity and function. Here we construct regulatory networks in 10 human tissues including regulations among miRNAs, transcription factors and genes. The results reveal that TS miRNAs are regulated largely by non-tissue specific TFs. TS miRNAs connect with more TFs compared with trivial miRNAs, inferring tight co-regulation of gene expression for TS miRNAs and TFs. Both TS miRNAs and TSTFs tend to regulate broad sets of genes involved in tissue specific functions. In particular, we identified tissue specific regulations instrumental to defining tissue specific functions, and some pathways important to tissue identity or disease, which cannot be explained by only tissue specific genes, can be captured in our tissue specific regulations.

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Acknowledgements

This work was supported by the grants of the National Science Foundation of China, Nos. 61133010, 61520106006, 31571364, 61532008, 61572364, 61373105, 61303111, 61411140249, 61402334, 61472282, 61472280, 61472173, 61572447, and 61373098, China Postdoctoral Science Foundation Grant, Nos. 2014M561513 and 2015M580352.

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Authors and Affiliations

  1. Institute of Machine Learning and Systems Biology, College of Electronics and Information Engineering, Tongji University, Shanghai, 201804, China

    Wei-Li Guo & De-Shuang Huang

  2. Department of Computer Science and Engineering, Inha University, Incheon, South Korea

    Kyungsook Han

Authors
  1. Wei-Li Guo
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  2. Kyungsook Han
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  3. De-Shuang Huang
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Correspondence to De-Shuang Huang .

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Editors and Affiliations

  1. Tongji University , Shanghai, China

    De-Shuang Huang

  2. Polytechnic of Bari , Bari, Italy

    Vitoantonio Bevilacqua

  3. University of Wollongong , North Wollongong, New South Wales, Australia

    Prashan Premaratne

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Guo, WL., Han, K., Huang, DS. (2016). Analysis of MicroRNA and Transcription Factor Regulation. In: Huang, DS., Bevilacqua, V., Premaratne, P. (eds) Intelligent Computing Theories and Application. ICIC 2016. Lecture Notes in Computer Science(), vol 9771. Springer, Cham. https://doi.org/10.1007/978-3-319-42291-6_27

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  • DOI: https://doi.org/10.1007/978-3-319-42291-6_27

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-42290-9

  • Online ISBN: 978-3-319-42291-6

  • eBook Packages: Computer ScienceComputer Science (R0)

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