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Research into the Cellular and Molecular Mechanisms of Regeneration in Salamanders: Then and Now

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Innovations in Molecular Mechanisms and Tissue Engineering

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Urodele amphibians are unrivalled in their ability to regenerate as adults and provide a unique template in which to study the faithful repair of tissues and organs in tetrapods. They display a robust capacity to regenerate a range of clinically relevant tissues including the limb, heart, brain, tail, spinal cord, lens, retina, liver, jaw, muscle, skin and bone joints. Historically approaches to delineate the mechanisms of regeneration have been limited to simple surgical procedures, however renewed interest in the field of regenerative medicine has spawned development and adaptation of modern molecular tools to several species. Here we present a comprehensive review of the major research findings in the field of regeneration that have been reported utilizing the salamander with a natural bias toward the regenerating limb. We discuss both the tissue and molecular requirements of regeneration in several tissues as well as the challenges associated with sequencing the salamander genomes. Finally we provide perspectives on the future research directions to explore and how these strategies should utilize both unique gain of function assays and modern genome editing tools to initiate translation into mammalian models of regeneration.

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Authors and Affiliations

  1. Australian Regenerative Medicine Institute, Monash University, Melbourne, VIC, Australia

    Ryan J. Debuque & James W. Godwin

  2. The Jackson Laboratory, Bar Harbor, ME, USA

    James W. Godwin

  3. The MDI Biological Laboratory, Bar Harbor, ME, USA

    James W. Godwin

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  1. Ryan J. Debuque
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  1. School of Life Sciences Arizona State University, Tempe, Arizona, USA

    Jeanne Wilson-Rawls

  2. Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA

    Kenro Kusumi

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Debuque, R.J., Godwin, J.W. (2016). Research into the Cellular and Molecular Mechanisms of Regeneration in Salamanders: Then and Now. In: Wilson-Rawls, J., Kusumi, K. (eds) Innovations in Molecular Mechanisms and Tissue Engineering. Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-44996-8_1

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