Skip to main content
SpringerLink
Log in

Botulinum Toxin Endoscopic Injection for Pelvic Pain

  • Chapter
  • First Online:
Urological and Gynaecological Chronic Pelvic Pain

Abstract

Botulinum toxin (BoNT) has demonstrated effectiveness in the treatment of several pain disorders, including focal dystonia, cervical dystonia/spastic torticollis, spasmodic dysphonia, oromandibular dystonia, temporomandibular disorder, refractory myofascial pain syndrome, tension, and migraine-type headache (Smith et al., Clin J Pain 18(6 Suppl):S147–54, 2002). These positive results of BoNT helping pain have stimulated interest on the use of BoNT for a variety of genitourinary pain conditions.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

aboBoNT-A:

AbobotulinumtoxinA

AUA:

American Urological Association

BoNT:

Botulinum toxin

GRA:

Global response assessment

IC/BPS:

Interstitial cystitis/bladder pain syndrome

ICPI:

Interstitial Cystitis Problem Index

ICSI:

Interstitial Cystitis Symptom Index

NIDDK:

National Institute of Diabetes and Digestive and Kidney Diseases

onaBoNT-A:

OnabotulinumtoxinA

rimaBoNT-B:

RimabotulinumtoxinB

VAS:

Visual analog scores

References

  1. Smith HS, Audette J, Royal MA. Botulinum toxin in pain management of soft tissue syndromes. Clin J Pain. 2002;18(6 Suppl):S147–54.

    Article  PubMed  Google Scholar 

  2. Aoki KR. Review of a proposed mechanism for the antinociceptive action of botulinum toxin type A. Neurotoxicology. 2005;26(5):785–93.

    Article  CAS  PubMed  Google Scholar 

  3. Chuang YC, Yoshimura N, Huang CC, Chiang PH, Chancellor MB. Intravesical botulinum toxin a administration produces analgesia against acetic acid induced bladder pain responses in rats. J Urol. 2004;172(4 Pt 1):1529–32.

    Article  CAS  PubMed  Google Scholar 

  4. Chancellor MB, Smith CP. Botulinum toxin in urology. 1st ed. Berlin Heidelberg: Springer; 2011.

    Book  Google Scholar 

  5. Liu HT, Kuo HC. Intravesical botulinum toxin A injections plus hydrodistention can reduce nerve growth factor production and control bladder pain in interstitial cystitis. Urology. 2007;70(3):463–8.

    Article  PubMed  Google Scholar 

  6. Kuo HC. Will suburothelial injection of small dose of botulinum A toxin have similar therapeutic effects and less adverse events for refractory detrusor overactivity? Urology. 2006;68(5):993–7. discussion 7-8.

    Article  PubMed  Google Scholar 

  7. Smith CP, Chancellor MB. Simplified bladder botulinum-toxin delivery technique using flexible cystoscope and 10 sites of injection. J Endourol. 2005;19(7):880–2.

    Article  PubMed  Google Scholar 

  8. Coelho A, Dinis P, Pinto R, Gorgal T, Silva C, Silva A, et al. Distribution of the high-affinity binding site and intracellular target of botulinum toxin type A in the human bladder. Eur Urol. 2010;57(5):884–90.

    Article  CAS  PubMed  Google Scholar 

  9. Mascarenhas F, Cocuzza M, Gomes CM, Leao N. Trigonal injection of botulinum toxin-A does not cause vesicoureteral reflux in neurogenic patients. Neurourol Urodyn. 2008;27(4):311–4.

    Article  CAS  PubMed  Google Scholar 

  10. Karsenty G, Elzayat E, Delapparent T, St-Denis B, Lemieux MC, Corcos J. Botulinum toxin type a injections into the trigone to treat idiopathic overactive bladder do not induce vesicoureteral reflux. J Urol. 2007;177(3):1011–4.

    Article  PubMed  Google Scholar 

  11. Barreveld AM, Correll DJ, Liu X, Max B, McGowan JA, Shovel L, et al. Ketamine decreases postoperative pain scores in patients taking opioids for chronic pain: results of a prospective, randomized, double-blind study. Pain Med. 2013;14(6):925–34.

    Article  PubMed  Google Scholar 

  12. Smith CP, Radziszewski P, Borkowski A, Somogyi GT, Boone TB, Chancellor MB. Botulinum toxin a has antinociceptive effects in treating interstitial cystitis. Urology. 2004;64(5):871–5. discussion 5.

    Article  PubMed  Google Scholar 

  13. Kuo HC, Chancellor MB. Comparison of intravesical botulinum toxin type A injections plus hydrodistention with hydrodistention alone for the treatment of refractory interstitial cystitis/painful bladder syndrome. BJU Int. 2009;104(5):657–61.

    Article  CAS  PubMed  Google Scholar 

  14. Manning J, Dwyer P, Rosamilia A, Colyvas K, Murray C, Fitzgerald E. A multicentre, prospective, randomised, double-blind study to measure the treatment effectiveness of abobotulinum A (AboBTXA) among women with refractory interstitial cystitis/bladder pain syndrome. Int Urogynecol J. 2014;25(5):593–9.

    Article  PubMed  Google Scholar 

  15. Kuo HC, Jiang YH, Tsai YC, Kuo YC. Intravesical botulinum toxin-A injections reduce bladder pain of interstitial cystitis/bladder pain syndrome refractory to conventional treatment – a prospective, multicenter, randomized, double-blind, placebo-controlled clinical trial. Neurourol Urodyn. 2016;35(5):609–14.

    Article  CAS  PubMed  Google Scholar 

  16. Giannantoni A, Costantini E, Di Stasi SM, Tascini MC, Bini V, Porena M. Botulinum A toxin intravesical injections in the treatment of painful bladder syndrome: a pilot study. Eur Urol. 2006;49(4):704–9.

    Article  CAS  PubMed  Google Scholar 

  17. Kuo HC. Preliminary results of suburothelial injection of botulinum a toxin in the treatment of chronic interstitial cystitis. Urol Int. 2005;75(2):170–4.

    Article  CAS  PubMed  Google Scholar 

  18. Pinto R, Lopes T, Frias B, Silva A, Silva JA, Silva CM, et al. Trigonal injection of botulinum toxin A in patients with refractory bladder pain syndrome/interstitial cystitis. Eur Urol. 2010;58(3):360–5.

    Article  CAS  PubMed  Google Scholar 

  19. Giannantoni A, Mearini E, Del Zingaro M, Proietti S, Porena M. Two-year efficacy and safety of botulinum a toxin intravesical injections in patients affected by refractory painful bladder syndrome. Curr Drug Deliv. 2010;7(1):1–4.

    Article  CAS  PubMed  Google Scholar 

  20. Kuo HC. Repeated onabotulinumtoxin-a injections provide better results than single injection in treatment of painful bladder syndrome. Pain Physician. 2013;16(1):E15–23.

    PubMed  Google Scholar 

  21. Pinto R, Lopes T, Silva J, Silva C, Dinis P, Cruz F. Persistent therapeutic effect of repeated injections of onabotulinum toxin a in refractory bladder pain syndrome/interstitial cystitis. J Urol. 2013;189(2):548–53.

    Article  CAS  PubMed  Google Scholar 

  22. Lee CL, Kuo HC. Intravesical botulinum toxin a injections do not benefit patients with ulcer type interstitial cystitis. Pain Physician. 2013;16(2):109–16.

    PubMed  Google Scholar 

  23. Pinto R, Lopes T, Costa D, Barros S, Silva J, Silva C, et al. Ulcerative and nonulcerative forms of bladder pain syndrome/interstitial cystitis do not differ in symptom intensity or response to onabotulinum toxin A. Urology. 2014;83(5):1030–4.

    Article  PubMed  Google Scholar 

  24. Gottsch HP, Miller JL, Yang CC, Berger RE. A pilot study of botulinum toxin for interstitial cystitis/painful bladder syndrome. Neurourol Urodyn. 2011;30(1):93–6.

    Article  CAS  PubMed  Google Scholar 

  25. Hesse S, Jahnke MT, Luecke D, Mauritz KH. Short-term electrical stimulation enhances the effectiveness of Botulinum toxin in the treatment of lower limb spasticity in hemiparetic patients. Neurosci Lett. 1995;201(1):37–40.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

The authors would like to express their gratitude to Elizabeth Barrick for her assistance in completing this work.

Author information

Authors and Affiliations

  1. Scott Department of Urology, Baylor College of Medicine, 7200 Cambridge Street, Suite 10B, Houston, TX, 77030, USA

    Christopher P. Smith M.D., M.B.A., M.S.S.

  2. Beaumont Health System, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USA

    Michael B. Chancellor M.D.

Authors
  1. Christopher P. Smith M.D., M.B.A., M.S.S.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michael B. Chancellor M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Christopher P. Smith M.D., M.B.A., M.S.S. .

Editor information

Editors and Affiliations

  1. The Arthur Smith Institute for Urology, Hofstra Northwell School of Medicine, Northwell Health, Lake Success, New York, USA

    Robert M. Moldwin

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Cite this chapter

Smith, C.P., Chancellor, M.B. (2017). Botulinum Toxin Endoscopic Injection for Pelvic Pain. In: Moldwin, R. (eds) Urological and Gynaecological Chronic Pelvic Pain. Springer, Cham. https://doi.org/10.1007/978-3-319-48464-8_23

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-48464-8_23

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-48462-4

  • Online ISBN: 978-3-319-48464-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation