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Transrectal Laser Focal Therapy of Prostate Cancer

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Imaging and Focal Therapy of Early Prostate Cancer

Part of the book series: Current Clinical Urology ((CCU))

Abstract

Laser focal therapy (LFT) is an evolving ablative technique for the treatment of prostate cancer. Also referred to as laser interstitial thermal therapy (LITT) or focal laser ablation (FLA), this intervention is based on heating of the prostate with an infrared laser to produce tissue destruction from coagulative necrosis. While earlier work focused on a transperineal approach, this has evolved to a less-invasive, transrectal approach delivered in the outpatient setting. This chapter examines the history, mechanism of action, and technique of transrectal magnetic resonance imaging (MRI)-guided LFT with real-time thermometry. We describe the equipment, procedure, and early safety and feasibility results of a series of patients in a clinical trial.

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Acknowledgments

The authors gratefully acknowledge the skill and expertise of our interventional radiologist, Stuart T. May, MD and our MRI technologist, Wes Jones, RT. We also acknowledge the early work of Roger J. McNichols, PhD, who saw the potential of light and harnessed it. Without him much of our work would have been impossible. We dedicate this chapter to him. BMG, JFF, and RJS.

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Authors and Affiliations

  1. Desert Medical Imaging, Indian Wells, CA, USA

    John F. Feller M.D.

  2. Clinical Services, Desert Medical Imaging, Indian Wells, CA, USA

    Bernadette M. Greenwood B.Sc.

  3. Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    R. Jason Stafford Ph.D.

Authors
  1. John F. Feller M.D.
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  2. Bernadette M. Greenwood B.Sc.
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  3. R. Jason Stafford Ph.D.
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Corresponding author

Correspondence to John F. Feller M.D. .

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Editors and Affiliations

  1. Department of Surgery, Duke Cancer Institute, Durham, North Carolina, USA

    Thomas J. Polascik

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Feller, J.F., Greenwood, B.M., Stafford, R.J. (2017). Transrectal Laser Focal Therapy of Prostate Cancer. In: Polascik, T. (eds) Imaging and Focal Therapy of Early Prostate Cancer. Current Clinical Urology. Springer, Cham. https://doi.org/10.1007/978-3-319-49911-6_25

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  • DOI: https://doi.org/10.1007/978-3-319-49911-6_25

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-49910-9

  • Online ISBN: 978-3-319-49911-6

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