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Interindividual Spread of Herpesviruses

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Cell Biology of Herpes Viruses

Part of the book series: Advances in Anatomy, Embryology and Cell Biology ((ADVSANAT,volume 223))

Abstract

Interindividual spread of herpesviruses is essential for the virus life cycle and maintenance in host populations. For most herpesviruses, the virus-host relationship is close, having coevolved over millions of years resulting in comparatively high species specificity. The mechanisms governing interindividual spread or horizontal transmission are very complex, involving conserved herpesviral and cellular proteins during the attachment, entry, replication, and egress processes of infection. Also likely, specific herpesviruses have evolved unique viral and cellular interactions during cospeciation that are dependent on their relationship. Multiple steps are required for interindividual spread including virus assembly in infected cells; release into the environment, followed by virus attachment; and entry into new hosts. Should any of these steps be compromised, transmission is rendered impossible. This review will focus mainly on the natural virus-host model of Marek’s disease virus (MDV) in chickens in order to delineate important steps during interindividual spread.

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Acknowledgments

The author would like to thank Dr. Klaus Osterrieder for critically evaluating the review. The data generated for this review were conducted with support from Agriculture and Food Research Initiative competitive grant nos. 2010-65119-20493, 2013-67015-21333, and 2016-67015-24917 from the USDA National Institute of Food and Agriculture to KWJ.

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  1. Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, 61802, USA

    Keith W. Jarosinski

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  1. Institut für Virologie, Freie Universität Berlin, Berlin, Germany

    Klaus Osterrieder

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Jarosinski, K.W. (2017). Interindividual Spread of Herpesviruses. In: Osterrieder, K. (eds) Cell Biology of Herpes Viruses. Advances in Anatomy, Embryology and Cell Biology, vol 223. Springer, Cham. https://doi.org/10.1007/978-3-319-53168-7_9

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