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Nonmelanoma Skin Cancer Actinic Keratosis and Squamous Cell Carcinoma

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Mechanisms of Molecular Carcinogenesis – Volume 2

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Abstract

Nonmelanoma skin cancer is the most common malignant tumor in Caucasians. Its pathogenesis is multifactorial. With a special focus on actinic keratosis and squamous cell carcinoma, we will give a short overview concerning basic knowledge and current histological classifications. Further, we discuss tumorigenesis and influencing factors, such as UV radiation, the inflammatory environment, hypoxia, presence of viruses, and the roles of the innate and adaptive immune system. Moreover, we give a short overview about targeted therapy of actinic keratosis and squamous cell carcinoma.

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Authors and Affiliations

  1. Medical University of Graz, University Clinic of Dermatology and Venerology, Auenbruggerplatz 8, 8036, Graz, Austria

    Birgit Aigner, Franz Legat & Wolfgang Weger

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  1. Birgit Aigner
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  2. Franz Legat
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  3. Wolfgang Weger
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Correspondence to Birgit Aigner .

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  1. Department of Pathology, Medical Faculty, Otto von Guericke University Magdeburg, Magdeburg, Germany

    Johannes Haybaeck

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Aigner, B., Legat, F., Weger, W. (2017). Nonmelanoma Skin Cancer Actinic Keratosis and Squamous Cell Carcinoma. In: Haybaeck, J. (eds) Mechanisms of Molecular Carcinogenesis – Volume 2. Springer, Cham. https://doi.org/10.1007/978-3-319-53661-3_2

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