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Eating Disorders and Epigenetics

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Neuroepigenomics in Aging and Disease

Part of the book series: Advances in Experimental Medicine and Biology ((PMISB,volume 978))

Abstract

Eating disorders (EDs) are characterized by intense preoccupation with shape and weight and maladaptive eating practices. The complex of symptoms that characterize EDs often arise through the activation of latent genetic potentials by environmental exposures, and epigenetic mechanisms are believed to link environmental exposures to gene expression. This chapter provides an overview of genetic factors acting in the etiology of EDs. It then provides a background to the hypothesis that epigenetic mechanisms link stresses such as obstetric complications and childhood abuse as well as effects of malnutrition to eating disorders (EDs). The chapter then summarizes the emerging body of literature on epigenetics and EDs—mainly studies on DNA methylation in samples of anorexia and bulimia. The available evidence base suggests that an epigenetically informed perspective contributes in valuable ways to the understanding of why people develop EDs.

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Authors and Affiliations

  1. Eating Disorders Continuum, Douglas Institute, Montreal West Island Integrated University Health and Social Services Centre, 6875 LaSalle Blvd, Verdun, QC, Canada, H4H 1R3

    Lea Thaler Ph.D. & Howard Steiger Ph.D.

  2. Psychiatry Department, McGill University, Montréal, QC, Canada, H3A 1Y2

    Lea Thaler Ph.D. & Howard Steiger Ph.D.

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  1. Lea Thaler Ph.D.
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  2. Howard Steiger Ph.D.
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Correspondence to Lea Thaler Ph.D. .

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Editors and Affiliations

  1. Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), CATALONIA, Spain

    Raul Delgado-Morales

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Thaler, L., Steiger, H. (2017). Eating Disorders and Epigenetics. In: Delgado-Morales, R. (eds) Neuroepigenomics in Aging and Disease. Advances in Experimental Medicine and Biology(), vol 978. Springer, Cham. https://doi.org/10.1007/978-3-319-53889-1_5

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