Abstract
Lung cancer mortality after radon exposure in the Wismut cohort was analysed with the two-stage clonal expansion (TSCE) model. Careful examination of the results of this study suggests that model misspecification and individual error in radon exposure estimates may be leading to large uncertainties in the estimation of risk.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
BEIR VI, “Health effects of exposure to radon. Committee on the Biological Effects of Ionizing Radiation, National Research Council”, Washington, DC: National Academy Press (1999).
D.J. Brenner, “The significance of dose rate in assessing the hazards of domestic radon exposure”, Health Phys. 67 (2015), 76–79.
M. Kreuzer et al., “Lung cancer risk at low radon exposure rates in German uranium miners”, Br. J. Cancer 113 (2015), 1367–1369.
K. Leuraud et al., “Radon, smoking and lung cancer risk: results of a joint analysis of three European case-control studies among uranium miners”, Radiat. Res. 176 (2011) 375–387.
S.H. Moolgavkar, “Model of human carcinogenesis: action of environmental agents”, Environ. Health Perspect. 50 (1983), 285–291.
S.H. Moolgavkar and E.G. Luebeck, “Two-event model for carcinogenesis: biological, mathematical and statistical considerations”, Risk Anal. 10 (1990), 323–341.
National Institute for Occupational Safety and Health (NIOSH), “Criteria for a recommended standard: occupational exposure to crystalline silica”, DHEW (NIOSH) Publication (1974), 75–120.
M. Schnelzer et al., “Accounting for smoking in the radon-related lung cancer risk among german uranium miners: results of a nested case-control study”, Health Phys. 98 (2010), 20–28.
M. Sogl et al., “Quantitative relationship between silica exposure and lung cancer mortality in German uranium miners, 1946–2003”, Br. J Cancer 107 (2012), 1188–1194.
L. Tomasek et al., “Lung cancer in French and Czech uranium workers: radon-associated risk at low exposure rates and modifying effects of time since exposure and age at exposure”, Radiat. Res. 169 (2008), 125–137.
UNSCEAR 2000, “Sources and effects of ionizing radiation, Vol. II: effects”, United Nations, New York, (2000).
L. Walsh et al., “The influence of radon exposures on lung cancer mortality in German uranium miners, 1946–2003”, Radiat Res 173 (2010), 79–90.
I. Zaballa and M. Eidemüller, “Mechanistic study on lung cancer mortality after radon exposure in the Wismut cohort supports important role of clonal expansion in lung carcinogenesis”, Radiat Environ Biophys. 55(3) (2016), 299–315.
Acknowledgements
Work supported by the European Commission under FP7 EpiRadBio no. 269553.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer International Publishing AG
About this paper
Cite this paper
Zaballa, I., Eidemüller, M. (2017). Uncertainty Considerations Following a Mechanistic Analysis of Lung Cancer Mortality. In: Ainsbury, E., Calle, M., Cardis, E., Einbeck, J., Gómez, G., Puig, P. (eds) Extended Abstracts Fall 2015. Trends in Mathematics(), vol 7. Birkhäuser, Cham. https://doi.org/10.1007/978-3-319-55639-0_21
Download citation
DOI: https://doi.org/10.1007/978-3-319-55639-0_21
Published:
Publisher Name: Birkhäuser, Cham
Print ISBN: 978-3-319-55638-3
Online ISBN: 978-3-319-55639-0
eBook Packages: Mathematics and StatisticsMathematics and Statistics (R0)