Skip to main content
SpringerLink
Log in

Gastrointestinal Stromal Tumor

  • Chapter
  • First Online:
Soft Tissue Pathology for Clinicians

Part of the book series: Pathology for Clinicians ((PACLIN))

  • 855 Accesses

Abstract

The gastrointestinal tract (GI) can be affected by many of the same soft tissue neoplasms that involve other parts of the body, such as leiomyosarcoma, leiomyoma, schwannoma, and perineurioma. A few soft tissue neoplasms, however, are unique to the gastrointestinal tract. Of these, gastrointestinal stromal tumor is one of the most common. This tumor emanates from the interstitial cells of Cajal that normally coordinate peristalsis for digestion.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  1. Tryggvason G, Gislason HG, Magnusson MK, Jonasson JG. Gastrointestinal stromal tumors in Iceland, 1990–2003: the icelandic GIST study, a population-based incidence and pathologic risk stratification study. Int J Cancer. 2005;117(2):289–93.

    Article  CAS  PubMed  Google Scholar 

  2. Emile JF, Brahimi S, Coindre JM, Bringuier PP, Monges G, Samb P, et al. Frequencies of KIT and PDGFRA mutations in the MolecGIST prospective population-based study differ from those of advanced GISTs. Med Oncol. 2012;29(3):1765–72.

    Article  CAS  PubMed  Google Scholar 

  3. Hornick JL, editor. Practical soft tissue pathology: a diagnostic approach. 1st ed. Philadelphia: Saunders; 2013.

    Google Scholar 

  4. Miettinen M, Fetsch JF, Sobin LH, Lasota J. Gastrointestinal stromal tumors in patients with neurofibromatosis 1: a clinicopathologic and molecular genetic study of 45 cases. Am J Surg Pathol. 2006;30(1):90–6.

    Article  PubMed  Google Scholar 

  5. Nishida T, Hirota S, Taniguchi M, Hashimoto K, Isozaki K, Nakamura H, et al. Familial gastrointestinal stromal tumours with germline mutation of the KIT gene. Nat Genet. 1998;19(4):323–4.

    Article  CAS  PubMed  Google Scholar 

  6. Stratakis CA, Carney JA. The triad of paragangliomas, gastric stromal tumours and pulmonary chondromas (Carney triad), and the dyad of paragangliomas and gastric stromal sarcomas (Carney-Stratakis syndrome): molecular genetics and clinical implications. J Intern Med. 2009;266(1):43–52.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Miettinen M, Wang ZF, Lasota J. DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors: a study of 1840 cases. Am J Surg Pathol. 2009;33(9):1401–8.

    Article  PubMed  Google Scholar 

  8. Hornick JL, editor. Practical soft tissue pathology: a diagnostic approach. Philadelphia: Saunders; 2013.

    Google Scholar 

  9. Patil DT, Rubin BP. Genetics of gastrointestinal stromal tumors: a heterogeneous family of tumors? Surg Pathol Clin. 2015;8(3):515–24.

    Article  PubMed  Google Scholar 

  10. Miettinen M, Sobin LH, Lasota J. Gastrointestinal stromal tumors of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic study of 1765 cases with long-term follow-up. Am J Surg Pathol. 2005;29(1):52–68.

    Article  PubMed  Google Scholar 

  11. Joensuu H. Risk stratification of patients diagnosed with gastrointestinal stromal tumor. Hum Pathol. 2008;39(10):1411–9.

    Article  PubMed  Google Scholar 

  12. Joensuu H, Vehtari A, Riihimaki J, Nishida T, Steigen SE, Brabec P, et al. Risk of recurrence of gastrointestinal stromal tumour after surgery: an analysis of pooled population-based cohorts. Lancet Oncol. 2012;13(3):265–74.

    Article  PubMed  Google Scholar 

  13. Miettinen M, Lasota J. Gastrointestinal stromal tumors: pathology and prognosis at different sites. Semin Diagn Pathol. 2006;23(2):70–83.

    Article  PubMed  Google Scholar 

  14. Debiec-Rychter M, Sciot R, Le Cesne A, Schlemmer M, Hohenberger P, van Oosterom AT, et al. KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumours. Eur J Cancer. 2006;42(8):1093–103.

    Article  CAS  PubMed  Google Scholar 

  15. Heinrich MC, Maki RG, Corless CL, Antonescu CR, Harlow A, Griffith D, et al. Primary and secondary kinase genotypes correlate with the biological and clinical activity of sunitinib in imatinib-resistant gastrointestinal stromal tumor. J Clin Oncol. 2008;26(33):5352–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, University of Manitoba Max Rady College of Medicine, Winnipeg, MB, Canada

    Kyle Perry

Authors
  1. Kyle Perry
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Cite this chapter

Perry, K. (2017). Gastrointestinal Stromal Tumor. In: Soft Tissue Pathology for Clinicians. Pathology for Clinicians. Springer, Cham. https://doi.org/10.1007/978-3-319-55654-3_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-55654-3_13

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-55653-6

  • Online ISBN: 978-3-319-55654-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation