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Anchoring Junctions in the Oral Mucosa: Adherens Junctions and Desmosomes

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Oral Mucosa in Health and Disease

Abstract

Adherens junctions and desmosomes confer strong adhesion and thus occur with high frequency in epithelia that are subject to extensive mechanical stress. Both anchoring junctions are linked to the cytoskeletal filaments and provide scaffolds for the maintenance of tissue integrity. The adhesion cores of all junctions consist of the transmembrane proteins that mediate direct interactions between adjacent cells. On the cytoplasmic site the transmembrane proteins are coupled to cytoskeleton via a collection of adaptor proteins. The importance of each group of junctions, their constitutive proteins, tissue expression as well as the associated diseases are discussed in this chapter.

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Authors and Affiliations

  1. Centre for Immunobiology and Regenerative Medicine, Institute of Dentistry, Bart and The London School of Medicine and Dentistry, London, UK

    Hong Wan, Hanan Gadmor & Louise Brown

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  1. Hong Wan
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  2. Hanan Gadmor
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Correspondence to Hong Wan .

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  1. Centre for Oral Immunobiology and Regenerative Medicine Institute of Dentistry, Queen Mary School of Medicine and Dentistry, London, United Kingdom

    Lesley Ann Bergmeier

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Wan, H., Gadmor, H., Brown, L. (2018). Anchoring Junctions in the Oral Mucosa: Adherens Junctions and Desmosomes. In: Bergmeier, L. (eds) Oral Mucosa in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-56065-6_3

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