Abstract
Structured sparsity penalization has recently improved statistical models applied to high-dimensional data in various domains. As an extension to medical imaging, the present work incorporates priors on network hierarchies of brain regions into logistic-regression to distinguish neural activity effects. These priors bridge two separately studied levels of brain architecture: functional segregation into regions and functional integration by networks. Hierarchical region-network priors are shown to better classify and recover 18 psychological tasks than other sparse estimators. Varying the relative importance of region and network structure within the hierarchical tree penalty captured complementary aspects of the neural activity patterns. Local and global priors of neurobiological knowledge are thus demonstrated to offer advantages in generalization performance, sample complexity, and domain interpretability.
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References
Abraham, A., Pedregosa, F., Eickenberg, M., Gervais, P., Mueller, A., Kossaifi, J., Gramfort, A., Thirion, B., Varoquaux, G.: Machine learning for neuroimaging with scikit-learn. Front. Neuroinform. 8, 14 (2014)
Anderson, M.L., Kinnison, J., Pessoa, L.: Describing functional diversity of brain regions and brain networks. Neuroimage 73, 50ā58 (2013)
Bach, F., Jenatton, R., Mairal, J., Obozinski, G.: Optimization with sparsity-inducing penalties. Found. Trends Mach. Learn. 4(1), 1ā106 (2012)
Barch, D.M., Burgess, G.C., Harms, M.P., Petersen, S.E., Schlaggar, F.C.: Function in the human connectome: task-FMRI and individual differences in behavior. Neuroimage 80, 169ā189 (2013)
Beck, A., Teboulle, M.: A fast iterative shrinkage-thresholding algorithm for linear inverse problems. SIAM J. Imaging Sci. 2(1), 183ā202 (2009)
Beckmann, C.F., DeLuca, M., Devlin, J.T., Smith, S.M.: Investigations into resting-state connectivity using independent component analysis. Philos. Trans. R. Soc. Lond. B Biol. Sci. 360(1457), 1001ā1013 (2005)
Bzdok, D., Eickenberg, M., Grisel, O., Thirion, B., Varoquaux, G.: Semi-supervised factored logistic regression for high-dimensional neuroimaging data. In: Advances in Neural Information Processing Systems, pp. 3330ā3338 (2015)
Craddock, R.C., James, G.A., Holtzheimer, P.E., Hu, X.P., Mayberg, H.S.: A whole brain FMRI atlas generated via spatially constrained spectral clustering. Hum. Brain Mapp. 33(8), 1914ā19289 (2012)
Doria, V., Beckmann, C.F., Arichia, T., Merchanta, N., Groppoa, M., Turkheimerb, F.E., Counsella, S.J., Murgasovad, M., Aljabard, P., Nunesa, R.G., Larkmana, D.J., Reese, G., Edwards, A.D.: Emergence of resting state networks in the preterm human brain. Proc. Natl. Acad. Sci. USA 107(46), 20015ā20020 (2010)
Harchaoui, Z., Douze, M., Paulin, M., Dudik, M., Malick, J.: Large-scale image classification with trace-norm regularization. In: 2012 IEEE Conference on Computer Vision and Pattern Recognition (CVPR), pp. 3386ā3393. IEEE (2012)
Iaria, G., Fox, C.J., Waite, C.T., Aharon, I., Barton, J.J.: The contribution of the fusiform gyrus and superior temporal sulcus in processing facial attractiveness: neuropsychological and neuroimaging evidence. Neuroscience 155(2), 409ā422 (2008)
Jenatton, R., Gramfort, A., Michel, V., Obozinski, G., Bach, F., Thirion, B.: Multi-scale mining of FMRI data with hierarchical structured sparsity. SIAM J. Imaging Sci. 5(3), 835ā856 (2012)
Jenatton, R., Obozinski, G., Bach, F.: Structured sparse principal component analysis. arXiv preprint arXiv:0909.1440 (2009)
Kanwisher, N.: Functional specificity in the human brain: a window into the functional architecture of the mind. Proc. Natl. Acad. Sci. USA 107(25), 11163ā11170 (2010)
Passingham, R.E., Stephan, K.E., Kotter, R.: The anatomical basis of functional localization in the cortex. Nat. Rev. Neurosci. 3(8), 606ā616 (2002)
Pedregosa, F., Varoquaux, G., Gramfort, A., et al.: Scikit-learn: machine learning in python. J. Mach. Learn. Res. 12, 2825ā2830 (2011)
Sepulcre, J., Liu, H., Talukdar, T., Martincorena, I., Yeo, B.T.T., Buckner, R.L.: The organization of local and distant functional connectivity in the human brain. PLoS Comput. Biol. 6(6), e1000808 (2010)
Smith, S.M., Fox, P.T., Miller, K.L., Glahn, D.C., Fox, P.M., Mackay, C.E., Filippini, N., Beckmann, C.F.: Correspondence of the brainās functional architecture during activation and rest. Proc. Natl. Acad. Sci. USA 106(31), 13040ā13045 (2009)
Sporns, O.: Contributions and challenges for network models in cognitive neuroscience. Nat. Neurosci. 17(5), 652ā660 (2014)
Varoquaux, G., Gramfort, A., Thirion, B.: Small-sample brain mapping: sparse recovery on spatially correlated designs with randomization and clustering. arXiv preprint. arXiv:1206.6447 (2012)
Yuan, M., Lin, Y.: Model selection and estimation in regression with grouped variables. Philos. Trans. R. Soc. Lond. B Biol. Sci. 68(1), 49ā67 (2006)
Zeki, S.M.: Functional specialisation in the visual cortex of the rhesus monkey. Nature 274(5670), 423ā428 (1978)
Acknowledgement
The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 604102 (Human Brain Project).
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Bzdok, D., Eickenberg, M., Varoquaux, G., Thirion, B. (2017). Hierarchical Region-Network Sparsity for High-Dimensional Inference in Brain Imaging. In: Niethammer, M., et al. Information Processing in Medical Imaging. IPMI 2017. Lecture Notes in Computer Science(), vol 10265. Springer, Cham. https://doi.org/10.1007/978-3-319-59050-9_26
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