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Applications of Glycosaminoglycans in the Medical, Veterinary, Pharmaceutical, and Cosmetic Fields

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Industrial Applications of Renewable Biomass Products

Abstract

Glycosaminoglycans (GAGs) are complex polysaccharides ubiquitously present in the extracellular matrix of mammalian tissues, where they constitute the gelatinous material responsible for maintaining the cells together, in an intimate association with a variety of proteins. Although their structures are not strictly regular, they are composed of a repeating unit of a hexosamine-containing disaccharide. Most of them possess uronic acid residues, and with the exception of hyaluronic acid, they also carry sulfate groups. As a consequence of their high negative charge, they have an extraordinary capacity to absorb water. GAGs participate in many relevant biological processes by interaction with a plethora of proteins, and thus, a large number of applications in different fields have been conceived for GAGs and their derivatives.

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Authors and Affiliations

  1. Laboratoire de Glycochimie, des Antimicrobiens et des Agroressources (LG2A) CNRS UMR 7378, Institut de Chimie de Picardie CNRS FR 3085, Université de Picardie Jules Verne, 33 rue Saint Leu, 80039, Amiens Cedex, France

    José Kovensky & Eric Grand

  2. Facultad de Ciencias Exactas y Naturales, Departamento de Química Orgánica, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, C1428EHA, Buenos Aires, Argentina

    María Laura Uhrig

  3. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)-UBA, Centro de Investigación en Hidratos de Carbono (CIHIDECAR), Buenos Aires, Argentina

    María Laura Uhrig

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  1. José Kovensky
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  1. Facultad de Ciencias Exactas y Naturales, Departamento de Física, Laboratorio de Polímeros y Materiales Compuestos (LPM&C), Universidad de Buenos Aires, Buenos Aires, Argentina

    Silvia Nair Goyanes

  2. Facultad de Ciencias Exactas y Naturales, Departamento de Química Orgánica, Universidad de Buenos Aires, Buenos Aires, Argentina

    Norma Beatriz D’Accorso

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Kovensky, J., Grand, E., Uhrig, M.L. (2017). Applications of Glycosaminoglycans in the Medical, Veterinary, Pharmaceutical, and Cosmetic Fields. In: Goyanes, S., D’Accorso, N. (eds) Industrial Applications of Renewable Biomass Products. Springer, Cham. https://doi.org/10.1007/978-3-319-61288-1_5

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