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Pediatric Graft-Versus-Host Disease

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Abstract

Graft-versus-host disease (GVHD) is an important complication after hematopoietic stem cell transplantation (HSCT) in children, and is second only to disease relapse as a cause of death in this population. This chapter reviews the pathophysiology, incidence, clinical features, classification, and treatment of acute and chronic variants of this condition. Unique aspects of acute and chronic GVHD in the pediatric population are highlighted. Lastly, knowledge gaps and potential directions for further research are addressed.

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Recommended Reading

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  • Ferrara JLM, Levine JE, Reddy P, Holler E. Graft-versus-host disease. The Lancet. 2009;333:1550–61.

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  • Hymes SR, Alousi AM, Cowen EW. Graft-versus-host disease: Part I. Pathogenesis and clinical manifestations of graft-versus-host disease. J Am Acad Dermatol. 2012;66:515.e1.

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  • Hymes SR, Alousi AM, Cowen EW. Graft-versus-host disease: Part II. Management of cutaneous graft-versus-host disease. J Am Acad Dermatol. 2012;66:535.e2.

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Acknowledgment

Photographs are courtesy of Jennifer T. Huang, M.D.

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Author notes

  1. $Valerie Carlberg and Emily Simons contributed equally to this work.

Authors and Affiliations

  1. Division of Immunology, Dermatology Program, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA

    Valerie Carlberg M.D., Emily Simons M.P.H., Sophia Delano M.D. & Jennifer T. Huang M.D.

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  1. Valerie Carlberg M.D.
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  3. Sophia Delano M.D.
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  4. Jennifer T. Huang M.D.
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Correspondence to Jennifer T. Huang M.D. .

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  1. Harvard Medical School, Boston Children’s Hospital, Boston, Massachusetts, USA

    Jennifer T. Huang

  2. Washington University School of Medicine, St. Louis, Missouri, USA

    Carrie C. Coughlin

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Carlberg, V., Simons, E., Delano, S., Huang, J.T. (2018). Pediatric Graft-Versus-Host Disease. In: Huang, J., Coughlin, C. (eds) Skin Tumors and Reactions to Cancer Therapy in Children. Springer, Cham. https://doi.org/10.1007/978-3-319-66200-8_9

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  • DOI: https://doi.org/10.1007/978-3-319-66200-8_9

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  • Online ISBN: 978-3-319-66200-8

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