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Tracer Kinetics in Radionanomedicine

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Radionanomedicine

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

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Abstract

Quantification of the amount of radiolabeled nanomaterials distributed in the animal and human body is important for understanding their in vivo properties (e.g., target delivery, radiolabeling stability, and excretion pathway) and determining future applications. Tracer kinetic analyses could play a vital role in the success of radionanomedicine as it facilitates the development of clinically relevant nanomaterials by providing the pharmacokinetic information. In this chapter, we describe the methodology used in the tracer kinetic analysis of dynamic positron emission tomography (PET) and single photon emission computed tomography (SPECT), starting from how to record the time profiles of tracer concentration in the blood and tissues, two sources of data required for a tracer kinetic model. Compartment models commonly used in PET and SPECT tracer kinetic analysis and their operational equations for fitting the tissue time-activity curves will be introduced. Then, several robust parameter estimation methods will be described. Finally, we will introduce a few examples of the tracer kinetic analysis in radio-nanomaterial studies.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea

    Jae Sung Lee & Dong Soo Lee

  2. Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea

    Jae Sung Lee

  3. Department of Neuroscience, College of Medicine, Gachon University, Incheon, Republic of Korea

    Seongho Seo

  4. Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea

    Dong Soo Lee

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  1. Jae Sung Lee
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  2. Seongho Seo
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Correspondence to Jae Sung Lee .

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  1. Department of Nuclear Medicine, Seoul National University, Seoul, Korea (Republic of)

    Dong Soo Lee

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Lee, J.S., Seo, S., Lee, D.S. (2018). Tracer Kinetics in Radionanomedicine. In: Lee, D. (eds) Radionanomedicine. Biological and Medical Physics, Biomedical Engineering. Springer, Cham. https://doi.org/10.1007/978-3-319-67720-0_16

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