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Miscellaneous Drugs and Male Reproduction

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Impacts of Medications on Male Fertility

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1034))

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Abstract

In addition to main categories of medications believed to have negative impacts on male reproduction, there are a number of miscellaneous drugs with some evidence for such adverse reactions. Because of its widespread use and over-the-counter availability, the H2 receptor antagonist cimetidine is most concerning. As a competitive antagonist at androgen receptors, it can impact the HPG axis and semen quality. In this chapter, we review the studies of this drug and other histamine H2 receptor antagonists in men and experimental species. Several other medications are concerning and the evidence for negative effects on reproduction are covered: colchicine, domperidone, hydroxyurea, metformin, metoclopramide, mifepristone, retinoids, and statins.

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Acknowledgements

The authors thank the scientists who made the full texts of their work available to us, the hard working staff at the University of Missouri Health Sciences Library who found copies of papers from the older literature, and the patients who have participated in the many trials required to evaluate medication effects on male reproduction.

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Authors and Affiliations

  1. Obstetrics, Gynecology and Women’s Health, University of Missouri School of Medicine, Columbia, MO, USA

    Erma Z. Drobnis

  2. Department of Urology, University of Kansas Medical Center, Kansas City, KS, USA

    Ajay K. Nangia

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  1. Erma Z. Drobnis
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Drobnis, E.Z., Nangia, A.K. (2017). Miscellaneous Drugs and Male Reproduction. In: Impacts of Medications on Male Fertility. Advances in Experimental Medicine and Biology, vol 1034. Springer, Cham. https://doi.org/10.1007/978-3-319-69535-8_13

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