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Neurocognitive Disorders

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Psychiatric Disorders Late in Life

Abstract

Mild neurocognitive disorder is thought to be an intermediate stage between normal age-associated cognitive changes and major neurocognitive disorder. Individuals with mild neurocognitive disorder have a faster rate of progression to major neurocognitive disorder than age-matched controls. Known risk factors for progression to major neurocognitive disorder include greater cognitive deficits at baseline, the presence of the APOE4 carrier gene, greater brain volume changes, cerebrospinal fluid changes, and the presence of neuropsychiatric symptoms. Current data indicates that the progression of mild neurocognitive disorder to major neurocognitive disorder can be delayed through the use of cognitive and physical training. Unfortunately, studies of pharmacotherapeutic agents do not indicate any benefit for cholinesterase inhibitors, the anti-inflammatory drug rofecoxib, and antioxidants in slowing the progression of mild neurocognitive disorder to major neurocognitive disorder.

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Authors and Affiliations

  1. Case Western Reserve University School of Medicine and Metrohealth, Cleveland, OH, USA

    Rajesh R. Tampi M.D., M.S., D.F.A.P.A. & Poorvanshi Alag M.D.

  2. Diamond Healthcare, Richmond, VA, USA

    Deena J. Tampi M.S.N., M.B.A.-H.C.A., R.N.

  3. Semel Institute for Neuroscience and Human Behavior, UCLA School of Medicine, Los Angeles, CA, USA

    Wynnelena C. Canio M.D.

  4. Harvard University, Cambridge, MA, USA

    Dhweeja Dasarathy

  5. Metrohealth, Cleveland, OH, USA

    Joel P. Dey M.D.

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  1. Rajesh R. Tampi M.D., M.S., D.F.A.P.A.
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Correspondence to Rajesh R. Tampi M.D., M.S., D.F.A.P.A. .

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  1. Professor of Psychiatry, Case Western Reserve University School of Medicine, Vice Chairman for Education and Faculty Development, Residency Program Director and Chief of Geriatric Psychiatry, MetroHealth, Cleveland, Ohio, USA

    Rajesh R. Tampi

  2. Executive Vice President, Clinical Services, Diamond Healthcare, Richmond, Virginia, USA

    Deena J. Tampi

  3. Associate Clinical Professor of Psychiatry, University of Wisconsin School of Medicine and Public Health Program Director, Geriatric Psychiatry Fellowship, Madison, Wisconsin, USA

    Lisa L. Boyle

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Tampi, R.R., Tampi, D.J., Canio, W.C., Alag, P., Dasarathy, D., Dey, J.P. (2018). Neurocognitive Disorders. In: Tampi, R., Tampi, D., Boyle, L. (eds) Psychiatric Disorders Late in Life. Springer, Cham. https://doi.org/10.1007/978-3-319-73078-3_16

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