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Cell-Penetrating Peptides Targeting Mitochondria

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Mitochondrial Biology and Experimental Therapeutics

Abstract

Mitochondria are key organelles with essential functions and fundamental roles in cell death and survival signaling. Consequently, they are involved in a wide range of diseases with a great diversity of clinical appearance, which makes them attractive as target for drugs to treat metabolic and degenerative diseases and cancer. Efficient methods for specific intracellular delivery of exogenous compounds, including biochemically active small molecules, imaging agents, peptides, peptide nucleic acids, proteins, RNA, DNA, and nanoparticles, would be beneficial for research and patients. A sustained effort in the last 20 years has been done to exploit cell-penetrating peptides (CPPs) for the delivery of such useful cargoes in vitro and in vivo because of their biocompatibility, ease of synthesis, and controllable physical chemistry. Here, we discuss the mechanisms by which CPPs can function, the use of this alternative as well as strategies used to target mitochondria and the implications for drug delivery.

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Acknowledgments

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript. This work was supported by the Swedish Research Council for Natural Sciences (621-2011-5902), the Swedish Research Council for Medical Research (K2012-66X-21148-04-5), and the Swedish Cancer Foundation (CAN 2014/259).

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  1. The Arrhenius Laboratories for Natural Sciences, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden

    Carmine Pasquale Cerrato & Ülo Langel

  2. Laboratory of Molecular Biotechnology, Institute of Technology, University of Tartu, Tartu, Estonia

    Ülo Langel

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  1. Carmine Pasquale Cerrato
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Correspondence to Carmine Pasquale Cerrato .

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  1. CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal

    Paulo J. Oliveira

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Cerrato, C.P., Langel, Ü. (2018). Cell-Penetrating Peptides Targeting Mitochondria. In: Oliveira, P. (eds) Mitochondrial Biology and Experimental Therapeutics. Springer, Cham. https://doi.org/10.1007/978-3-319-73344-9_26

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