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Heat Shock Protein 70 and Other Heat Shock Proteins in Diseased Retina

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HSP70 in Human Diseases and Disorders

Part of the book series: Heat Shock Proteins ((HESP,volume 14))

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Abstract

Heat shock proteins (HSP) belong to a family of stress-induced proteins essential to cell survival. HSP have multiple protective roles through assistance in protein folding, maintaining mitochondrial homeostasis, suppressing proinflammatory cytokines, resisting ischemic damage and protecting cells from apoptotic and necrotic death. This chapter discusses the important roles of HSP, particularly HSP70 in enhancing the survival of neurons in retinal disease through different pathways. Studies in various retinal cell lines, animal models and human tissue demonstrate altered HSP expression under different stresses and diseases. These findings implicate the critical role of. HSP in the diseased retina as well as providing support for translating the HSP’ cellular defense strategy into therapy to protect and rescue injured retina from different retinal pathology.

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Abbreviations

AMD:

age-related macular degeneration

DR:

diabetic retinopathy

GGA:

geranylgeranylacetone

HSP:

heat shock proteins

LC-MS/MS:

liquid chromatography tandem-mass spectrometry

NFκB:

nuclear factor-κB

RGCs:

retinal ganglion cells

RPE:

retinal pigment epithelium

STZ:

streptozotocin 

TNF:

tumour necrosis factor

VEGF:

vascular endothelial growth factor

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Acknowledgements

This work was supported in part by the University of Sydney Postgraduate Award (to B. B.) and Early Career Researcher Kick Start Grant from the Balnaves Foundation and Sydney Medical School (to L. Z.)

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Authors and Affiliations

  1. State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China

    Ting Zhang

  2. Save Sight Institute, The University of Sydney, Sydney, NSW, Australia

    Ting Zhang, Bobak Bahrami & Ling Zhu

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  1. Ting Zhang
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  2. Bobak Bahrami
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  3. Ling Zhu
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Correspondence to Ling Zhu .

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Editors and Affiliations

  1. Department of Medicine and Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    Punit Kaur

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Zhang, T., Bahrami, B., Zhu, L. (2018). Heat Shock Protein 70 and Other Heat Shock Proteins in Diseased Retina. In: Asea, A., Kaur, P. (eds) HSP70 in Human Diseases and Disorders. Heat Shock Proteins, vol 14. Springer, Cham. https://doi.org/10.1007/978-3-319-89551-2_14

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