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Heat Shock Proteins and Endoplasmic Reticulum Stress

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Heat Shock Proteins and Stress

Part of the book series: Heat Shock Proteins ((HESP,volume 15))

Abstract

The endoplasmic reticulum (ER) is a dynamic as well as an intricate organelle that carries out diverse essential functions within the cell. The efficient functions of the ER regulate the cellular processes and maintain cell homeostasis. When this dynamic equilibrium gets imbalanced due to perturbations in the ER functions, a condition termed ER stress occurs. ER stress accumulates and aggregates unfolded proteins within the ER lumen. An evolutionarily conserved signal transduction mechanism called unfolded protein response (UPR) recuperates the ER function and proteostasis in the ER. A diverse group of heat shock proteins (HSP) has been implicated in this ER stress response. In recent years, studies have revealed the roles of HSP in sensing the ER stress and activating the three axes of UPR. In addition, the HSP are also responsible for the ER associated degradation of unfolded proteins when ER stress persists for a long time. The HSP in ER stress have been implicated in diverse pathophysiological conditions like cardiovascular diseases, cancer, aging, diabetes and obesity. In the present chapter, we have summarized the advances made in the manifold roles of HSP that govern ER stress signaling in health.

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Acknowledgements

Azhwar Raghunath is the recipient of a University Grants Commission - Basic Scientific Research Senior Research Fellowship (UGC-BSR-SRF - No.F.7-25/2007) funded by UGC-BSR, New Delhi, India. We thank the Department of Science and Technology, Science and Engineering Board, New Delhi, for financial assistance (No.: SB/EMEQ-246/2014 and EMR/2014/000600). This work was also supported by the University Grants Commission – Special Assistance Programme (UGC-SAP-II:F-3-20/2013) and Department of Science and Technology, Fund for Improvement of Science and Technology infrastructure in universities and higher educational institutions (DST-FIST:SR/FST/LSI-618/2014), New Delhi, India.

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  1. Azhwar Raghunath, Lakshmikanthan Panneerselvam, Kiruthika Sundarraj are contributed equally to this work.

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  1. Molecular Toxicology Laboratory, Department of Biotechnology, Bharathiar University, Coimbatore, Tamilnadu, India

    Azhwar Raghunath, Lakshmikanthan Panneerselvam, Kiruthika Sundarraj & Ekambaram Perumal

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  1. Azhwar Raghunath
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  1. College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer, Houston, TX, USA

    Punit Kaur

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Raghunath, A., Panneerselvam, L., Sundarraj, K., Perumal, E. (2018). Heat Shock Proteins and Endoplasmic Reticulum Stress. In: Asea, A., Kaur, P. (eds) Heat Shock Proteins and Stress. Heat Shock Proteins, vol 15. Springer, Cham. https://doi.org/10.1007/978-3-319-90725-3_3

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