Abstract
Nail changes are a common side effect of systemic chemotherapy. Onycholysis is a severe form of nail toxicity in which the nail detaches from the nail bed. Cryotherapy can be effective in preventing chemotherapy induced nail changes as it enables cold-induced vasoconstriction (CIVC), or reduction of blood flow, and therefore limits the transport of chemotherapeutic agents towards the nail beds. Unfortunately, CIVC is inevitably followed up by cold-induced vasodilation (CIVD), causing the blood flow to increase again which reduces the effectiveness of the treatment. Moreover, the local use of extremely low temperatures induce pain and additional distress during chemo treatment. The objective of this article is to examine the usefulness of an active local cooling device for controlling blood flow in the fingertips and reducing CIVD, while limiting pain and discomfort. Three different cooling strategies are evaluated to compare their effectiveness in reducing CIVD. It is hypothesized that pulsating cooling reduces CIVD as it may limit body heat storage during the treatment.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Roh MR, Cho JY, Lew W (2007) Docetaxel-induced onycholysis: the role of subungual hemorrhage and suppuration. Yonsei Med J 48(1):124–126
Hussain S, Anderson DN, Salvatti ME, Adamson B, McManus M, Braverman AS (2000) Onycholysis as a complication of systemic chemotherapy: report of five cases associated with prolonged weekly paclitaxel therapy and review of the literature. Cancer 88(10):2367–2371
Gilbar P, Hain A, Peereboom VM (2009) Nail toxicity induced by cancer chemotherapy. J Oncol Pharm Pract 15(3):143–155
Minisini AM et al (2003) Taxane-induced nail changes: incidence, clinical presentation and outcome. Ann Oncol 14(2):333–337
Robert C et al (2015) Nail toxicities induced by systemic anticancer treatments. Lancet Oncol 16(4):e181–e189
Shanmugam Reddy PK, Shyam Prasad AL, Sumathy TK, Reddy RV (2017) Nail changes in patients undergoing cancer chemotherapy. Int J Res Dermatol 3(1):49
Kadakia KC, Rozell SA, Butala AA, Loprinzi CL (2014) Supportive cryotherapy: a review from head to toe. J Pain Symptom Manag 47(6):1100–1115
D’Haene M, Youssef A, De Bruyne G, Aerts J-M (2015) Modelling and controlling blood flow by active cooling of the fingers to prevent nail toxicity [master thesis]. KULeuven
Ulrich RS (2001) Effects of healthcare environmental design on medical outcomes. In: Second international conference on design and health, June, pp 49–59
Tyler CJ, Reeve T, Cheung SS (2015) Cold-induced vasodilation during single digit immersion in 0 °C and 8 °C water in men and women. PLoS ONE 10(4):1–13
Daanen HAM (2003) Finger cold-induced vasodilation: a review. Eur J Appl Physiol 89(5):411–426
Scotté F et al (2005) Multicenter study of a frozen glove to prevent docetaxel-induced onycholysis and cutaneous toxicity of the hand. J Clin Oncol 23(19):4424–4429
Steckel J et al (2013) A research platform using active local cooling directed at minimizing the blood flow in human fingers. In: Proceedings of ICTs for improving patients rehabilitation research technology, pp 81–84
Scotté F et al (2008) Matched case-control phase 2 study to evaluate the use of a frozen sock to prevent docetaxel-induced onycholysis and cutaneous toxicity of the foot. Cancer 112(7):1625–1631
Can G, Aydiner A, Cavdar I (2012) Taxane-induced nail changes: predictors and efficacy of the use of frozen gloves and socks in the prevention of nail toxicity. Eur J Oncol Nurs 16(3):270–275
Sawada S, Araki S, Yokoyama K (2000) Changes in cold-induced vasodilatation, pain and cold sensation in fingers caused by repeated finger cooling in a cool environment. Ind Health 38:79–86
Bladt L et al (2015) Cold-induced vasoconstriction for preventing onycholysis during cancer treatment. Extrem Physiol Med 4(1):A60
D’Haene M, Youssef A, De Bruyne G, Aerts J-M (2015) Modelling and controlling blood flow by active cooling of the fingers to prevent nail toxicity
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this paper
Cite this paper
De Boeck, M. et al. (2019). Prevention of Onycholysis During Cancer Treatment Using an Active Local Cooling Device: Comparison of Three Different Cooling Strategies. In: Bagnara, S., Tartaglia, R., Albolino, S., Alexander, T., Fujita, Y. (eds) Proceedings of the 20th Congress of the International Ergonomics Association (IEA 2018). IEA 2018. Advances in Intelligent Systems and Computing, vol 818. Springer, Cham. https://doi.org/10.1007/978-3-319-96098-2_28
Download citation
DOI: https://doi.org/10.1007/978-3-319-96098-2_28
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-96097-5
Online ISBN: 978-3-319-96098-2
eBook Packages: Intelligent Technologies and RoboticsIntelligent Technologies and Robotics (R0)