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Remitting Seronegative Symmetrical Synovitis and Pitting Edema

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Rare Rheumatic Diseases of Immunologic Dysregulation

Part of the book series: Rare Rheumatic Diseases ((RRD))

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Abstract

Remitting seronegative symmetrical synovitis and pitting edema (RS3PE) is an uncommon condition that is characterized as an acute polysynovitis associated with pitting edema that tends to affect individuals who are over 50 years of age. This condition was first described by McCarty et al. in 1985 and although now usually thought of as a separate entity was originally thought to represent a subset of late onset rheumatoid arthritis (LORA). The controversy over the last 30 years as to whether RS3PE is a separate entity or forms a part of a clinical spectrum that includes LORA and polymyalgia rheumatica (PMR) is due to the similarities in clinical and demographic characteristics that are shared by these conditions. Additionally, RS3PE is also considered a paraneoplastic condition as it is often associated with malignancy. In this chapter, we will discuss the epidemiological and clinical characteristics of RS3PE, associated conditions including malignancy, diagnosis and management, as well as current data on mechanism of disease pathogenesis including areas of ongoing research and future directions.

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Authors and Affiliations

  1. Division of Rheumatology, University of Pennsylvania Perelman School of Medicine, Penn Musculoskeletal Center, Philadelphia, PA, USA

    Annemarie Schorpion

  2. Department of Rheumatology, Chalmers P. Wylie VA Ambulatory Care Center, Columbus, OH, USA

    Reshmi Raveendran

  3. Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, USA

    Anupama Shahane

  4. Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA

    Mildred Kwan & Alfredo C. Rivadeneira

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  1. Annemarie Schorpion
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  2. Reshmi Raveendran
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  3. Anupama Shahane
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  4. Mildred Kwan
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  5. Alfredo C. Rivadeneira
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Correspondence to Alfredo C. Rivadeneira .

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  1. Department of Medicine, Duke University School of Medicine, Durham, NC, USA

    Teresa Kathleen Tarrant

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Schorpion, A., Raveendran, R., Shahane, A., Kwan, M., Rivadeneira, A.C. (2019). Remitting Seronegative Symmetrical Synovitis and Pitting Edema. In: Tarrant, T. (eds) Rare Rheumatic Diseases of Immunologic Dysregulation. Rare Rheumatic Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-99139-9_7

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  • DOI: https://doi.org/10.1007/978-3-319-99139-9_7

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