Abstract
New potential applications for botulinum neurotoxin (BoNT) therapy are constantly pointed out through the emerging literature in this field. In this chapter, we discuss potential indications for botulinum neurotoxin treatment in four fields of medicine: Psychiatry (depression), cardiology (irregular heart beats, atrial fibrillation) and pain medicine (cancer related pain, prevention of post-surgical pain, temporomandibular pain and pain associated with teeth grinding), dermatology (psoriasis and recalcitrant itch).
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References
Kessler RC, Berglund P, Demler, et al. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA. 2003;18(289):3095–105.
Wollmer MA, de Boer C, Kalak NT, et al. Facing depression with botulinum toxin: a randomized controlled trial. J Psychiatr Res. 2012;46:574–81.
Finzi E, Rosenthal NE. Treatment of depression with onabotulinumtoxinA: a randomized, double-blind, placebo- controlled trial. J Psychiatr Res. 2014;52:1–6.
Magid M, Reichenberg JS, Poth PE, et al. Treatment of major depressive disorder using botulinum toxin a: a 24-week randomized, double-blind, placebo-controlled study. Clin Psychiatry. 2014;75:837–44.
Hennenlotter A, Dresel C, Castrop F, et al. The link between facial feedback and neural activity within central circuitries of emotion--new insights from botulinum toxin-induced denervation of frown muscles. Cereb Cortex. 2009;19:537–42.
Go AS, Hylek EM. Phillips KA prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and risk factors in atrial fibrillation (ATRIA) study. JAMA. 2001;285:2370–5.
Pokushalov E, Kozlov B, Romanov A, et al. Long-Term Suppression of Atrial Fibrillation by Botulinum Toxin Injection Into Epicardial Fat Pads in Patients Undergoing Cardiac Surgery: One-Year Follow-Up of a Randomized Pilot Study. Circ Arrhythm Electrophysiol. 2015 Dec;8(6):1334–41.
Mittal S, Machado DG, Jabbari B. OnabotulinumtoxinA for treatment of focal cancer pain after surgery and/or radiation. Pain Med. 2012;13:1029–33.
Rostami R, Mittal SO, Radmand R, Jabbari B. Incobotulinum Toxin-A Improves Post-Surgical and Post-Radiation Pain in Cancer Patients. Toxins (Basel). 2016 Jan 13;8(1). pii: E22. doi: https://doi.org/10.3390/toxins8010022.
Davies J, Duffy D, Boyt N, et al. Botulinum toxin (botox) reduces pain after hemorrhoidectomy: results of a double-blind, randomized study. Dis Colon Rectum. 2003;46:1097–102.
National Institute of Dental and Craniofacial Research [7/28/2013]; Facial Pain. http://www.nidcr.nih.gov/DataStatistics/FindDataByTopic/FacialPain/
Patel AA, Lerner MZ, Blitzer A. IncobotulinumToxin-A for injection of temporo-mandibular joint disorder. A randomized controlled pilot study. 2017;126:328–33.
Mesko ME, Hutton B, Skupien JA, et al. Therapies for bruxism: a systematic review and network meta-analysis (protocol). Syst Rev. 2017;6:4. https://doi.org/10.1186/s13643-016-0397-z.
Ondo WG, Simmons JH, Shahid MH et al. Onabotulinum toxin-A injections for sleep bruxism: A double-blind, placebo-controlled study. Neurology. 2018 Jan 17. pii. doi: https://doi.org/10.1212/WNL.0000000000004951. [Epub ahead of print].
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Jabbari, B. (2018). Botulinum Toxin Therapy-Future Perspectives. In: Botulinum Toxin Treatment . Springer, Cham. https://doi.org/10.1007/978-3-319-99945-6_17
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DOI: https://doi.org/10.1007/978-3-319-99945-6_17
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