Skip to main content

Zusammenfassung

Mit den Veränderungen der Altersstruktur unserer Bevölkerung sind Demenzen zu einem gravierenden sozialen und gesundheitspolitischen Problem geworden, dessen Bedeutung noch weiter anwachsen wird. Die Prävalenz der Demenzen steigt exponentiell mit dem Alter an und beträgt bei den Über-65jährigen zwischen 6,5 und 8,7 Prozent. Dies entspricht einer Gesamtzahl von 830.000 bis 1,1 Millionen manifest an einer Demenz Erkrankten in der Bundesrepublik. Die Rate der jährlichen Neuerkrankungen liegt in der Altenbevölkerung zwischen 1,4 und 2 Prozent (Gao et al., 1998; Jorm und Jolley, 1998; Launer et al., 1999). Damit manifestieren sich in Deutschland im Verlauf von 12 Monaten bei 170.000 bis 240.000 Menschen dementielle Erkrankungen. Demenzen sind einer der wichtigsten Gründe für die Entstehung von Pflegebedürftigkeit und die Hauptursache für eine Inanspruchnahme von Pflegeheimen (Bickel,1996). Jährlich werden etwa bis zu 25 Prozent der zuvor in Privathaushalten lebenden Demenzkranken in Pflegeheime eingewiesen, in denen sie im Mittel zwischen 2,6 bis 3,1 Jahre verbringen. Anders als vor einigen Jahren übersiedeln jetzt zwei Drittel bis drei Viertel der Patienten im Verlauf der Erkrankung in ein Pflegeheim (Bickel, 1995b).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 49.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 84.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Reference

  • Adler G, Frölich L, Gertz H-J et al. (1999) Diagnostik and Therapie der Demenz in der Primärversorgung. Zeitschrift für Allgemeinmedizin. Stuttgart: Hippokrates, 26

    Google Scholar 

  • Aevarsson O, Svanborg A, Skoog I (1998) Seven-year survival rate after age 85 years. Arch Neurol 55: 1226–1232

    Google Scholar 

  • Aisen PS, Marin D, Altstiel L et al. (1996) A pilot study of prednisone in Alzheimer’s disease. Dementia 7: 201–206

    Google Scholar 

  • Ala TA, Yang KH, Sung JH et al. (1997) Hallucinations and signs of parkinsonism help distinguish patients with dementia and cortical Lewy bodies from patients with Alzheimer’s disease at presentation: a clinicopathological study. J Neurol Neurosurg Psychiat 62: 16–21

    Google Scholar 

  • Alexander GE, Furey ML, Grady CL et al. (1997) Association of premorbid intellectual function with cerebral metabolism in Alzheimer’s disease: Implications for the cognitive reserve hypothesis. Am J Psychiat 154: 165–172

    Google Scholar 

  • Andersen K, Launer LJ, Ott A et al. (1995) Do nonsteroidal anti-inflammatory drugs decrease the risk for Alzheimer’s disease? The Rotterdam study. Neurology 45: 1441–1445

    Google Scholar 

  • Andreasen N, Minthon L, Clarberg A et al. (1999) Sensitivity, specificity, and stability of CSF-tau in AD in a community-based patient sample. Neurology 53: 1488–1494

    Google Scholar 

  • Arendt T (1991) Das Syndrom der partiellen cholinergen Deafferentierung des kortikalen Mantels — ein Konzept zur Beschreibung des brain-behaviour-relationships bei dementiellen Erkrankungen. Fortschr Neurol Psychiatr 59: 81–91

    Google Scholar 

  • Arendt T, Bruckner MK, Bigl V et al. (1995) Dendritic reorganisation in the basal forebrain under degenerative conditions and its defects in Alzheimer’s disease. Ageing, Korsakoff’s disease, Parkinson’s disease, and Alzheimer’s disease. J Comp Neurol 351: 189–222

    Google Scholar 

  • Bancher C, Jellinger K, Lassmann H et al. (1996) Correlations between mental state and quantitative neuropathology in the Vienna longitudinal study on dementia. Eur Arch Psychiatry Clin Neurosci 246: 137–146

    Google Scholar 

  • Bartenstein P, Minoshima S, Hirsch C et al. (1997) Quantitative Assessment of cerebral blood flow in patients with Alzheimer’s Disease by SPECT. J Nucl Med 38: 1095–1101

    Google Scholar 

  • Baskin DS, Browning JL, Pirozzolo FJ et al. (1999) Brain choline acetyltransferase and mental function in Alzheimer disease. Arch Neurol 56: 1121–1123

    Google Scholar 

  • Bassuk SS, Glass TY, Berkman LF (1999) Social disengagement and incident cognitive decline in community-dwelling elderly persons. Ann Int Med 131: 165–173

    Google Scholar 

  • Beatty WW, Salmon DP, Butters N et al. (1988) Retrograde amnesia in patients with Alzheimer’s disease or Huntington’s disease. Neurobiol Aging 9: 181–86

    Google Scholar 

  • Bertram L, Busch R, Spiegl M et al. (1998) Paternal age is a risk factor for Alzheimer disease in the absence of a major gene. Neurogenetics 1: 277–280

    Google Scholar 

  • Besthorn C, Sattel H, Geiger-Kabisch C et al. (1994) EEG coherences in Alzheimer’s disease. EEG Clin Neurophysiol 90: 242–245

    Google Scholar 

  • Besthorn C, Sattel H, Geiger-Kabisch D et al. (1995) Parameters of EEG dimensional complexity in Alzheimer’s disease. EEG Clin Neurophysiol 95: 84–89

    Google Scholar 

  • Beyreuther K, Förstl H (1999) Die Zukunft der Prävention und Therapie. In: H Förstl, H Bickel, A Kurz (Hrsg.). Alzheimer Demenz: Grundlagen, Diagnostik und Therapie. Heidelberg: Springer, 213–233

    Google Scholar 

  • Bickel H (1995a) Demenzen im Alter: Eine populationsbezogene Untersuchung von Verteilung, Versorgung und Risikofaktoren. Abschlußbericht an das Bundesministerium für Forschung und Technologie.

    Google Scholar 

  • Bickel H (1995b) Demenzkranke in Alten-und Pflegeheimen: Gegenwärtige Situation und Entwicklungstendenzen. In: Forschungsinstitut der Friedrich-Ebert-Stiftung (Hrsg.). Medizinische und gesellschaftspolitische Herausforderung: Alzheimer Krankheit. Der langsame Zerfall der Persönlichkeit. Bonn: Friedrich-EbertStiftung, 49–68

    Google Scholar 

  • Bickel H (1996) Pflegebedürftigkeit im Alter. Ergebnisse einer populationsbezogenen retrospektiven Längsschnittstudie. Gesundh-Wes 58, Sonderheft 1: 56–62

    Google Scholar 

  • Bickel H (1997) Epidemiologie psychischer Erkrankungen im Alter. In: H Förstl (Hrsg.). Lehrbuch der Gerontopsychiatrie. Stuttgart: Enke, 1–16

    Google Scholar 

  • Bierer LM, Haroutunian V, Gabriel S et al. (1995) Neurochemical correlates of dementia severity in Alzheimer’s disease: relative importance of the cholinergic deficits. J Neurochem 64: 749–760

    Google Scholar 

  • Blacker D, Wilcox MA, Laird NM et al. (1998) Alpha-2 macroglobulin is genetically associated with Alzheimer disease. Nat Genet 19: 357–360

    Google Scholar 

  • Bobinski M, de Leon MJ, Convit A et al. (1999) MRI of entorhinal cortex in mild Alzheimer’s disease. Lancet 353: 38–40

    Google Scholar 

  • Boushey CJ, Shirley RD, Beresford AA et al. (1995) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. J Am Med Assoc 274: 1049–1057

    Google Scholar 

  • Bowen JD, Malter AD, Sheppard L et al. (1996) Predictors of mortality in patients diagnosed with probable Alzheimer’s disease. Neurology 47: 433–439

    Google Scholar 

  • Bowler JV, Munoz DG, Merskey H et al. (1998) Factors affecting the age of onset and rate of progression of Alzheimer’s disease. J Neurol Neurosurg Psychiat 65: 184–190

    Google Scholar 

  • Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82: 239–259

    Google Scholar 

  • Bracco L, Gallato R, Gricoletto F et al. (1994) Factors affecting course and survival in Alzheimer’s disease. A 9-year longitudinal study. Arch Neurol 51: 1213–1219

    Google Scholar 

  • Braekhus A, Laake K, Engedal K (1995) A low, „normal“ score on the Mini-Mental State Examination predicts development of dementia after three years. J Am Geriat Soc 43: 656–661

    Google Scholar 

  • Breitner JC, Gau BA, Welsh KA et al. (1994) Inverse association of anti-inflammatory treatments and Alzheimer’s disease: initial results of a co-twin control study. Neurology 44: 227–232

    Google Scholar 

  • Brugge K, Katzman R, Hill LR et al. (1995) Serological a-antichymotrypsin serum levels in a subset of nondemented first-degree relatives of Alzheimer’s disease patients. Dementia 6: 17–20

    Google Scholar 

  • Brun A, Gustafson L (1997) Fokal beginnende Hirnatrophie, „Morbus Pick“. In: H Förstl (Hrsg.). Lehrbuch der Gerontopsychiatrie. Stuttgart: Enke, 278–291

    Google Scholar 

  • Bundesärztekammer (1998) Grundsätze der Bundesärztekammer zur ärztlichen Sterbebegleitung. Deutsches Ärzteblatt 95: A 2365–2367

    Google Scholar 

  • Burns A, Jacoby R, Levy, R (1990) Psychiatric Phenomena in Alzheimer’s Disease. Brit J Psychiatr 157: 72–94

    Google Scholar 

  • Burns A, Lewis G, Jacoby R et al. (1991) Factors affecting survival in Alzheimer’s disease. Psychol Med 21: 363–370

    Google Scholar 

  • Callahan D (1987) Setting limits. Medical goals in an aging society. N.Y.: Simon & Schuster

    Google Scholar 

  • Cavallo MC, Fattore G (1997) The economic burden of Alzheimer disease on families in the Lombardy region of Italy. Alzheimer Dis Assoc Disord 11: 184–190

    Google Scholar 

  • Chapman FM, Dickinson J, McKeith I et al. (1999) Association among visual hallucinations, visual acuity, and specific eye pathologies in Alzheimer’s disease: treatment implications. Am J Psychiatry 156: 1983–1985

    Google Scholar 

  • Chen P, Ganguli M, Mulsant BH et al. (1999) The temporal relationship beween depressive symptoms and dementia. Arch Gen Psychiat 56: 261–266

    Google Scholar 

  • Chobor KL, Brown JW (1990) Semantic deterioration in Alzheimer’s: The patterns to expect. Geriatrics 45: 68–75

    Google Scholar 

  • Clark CM, Sheppard L, Fillenbaum GG et al. (1999) Variability in annual Mini-Mental State Examination score in patients with probable Alzheimer disease. Arch Neurol 56: 857–862

    Google Scholar 

  • Coffey CE, Saxton JA, Ratcliff G et al. (1999) Relation of education to brain size in normal aging. Implications for the reserve hypothesis. Neurology 53: 189–196

    Google Scholar 

  • Cohen CI, Strashun A, Ortega C et al. (1996) The effects of poverty and education on temporoparietal perfusion in Alzheimer’s disease: A reconsideration of the cerebral reserve hypothesis. Int J Ger Psychiatr 11: 1105–1110

    Google Scholar 

  • Collinge J (1999) Variant Creutzfeldt-Jakob disease. Lancet 354: 317–323

    Google Scholar 

  • Collinge J, Palmer MS (1997) Prion Diseases. Oxford: Oxford University Press

    Google Scholar 

  • Commissaris K, Verhey FRJ, Jolles JA (1996) Controlled study into the effects of psychoeducation for patients with cognitive disturbances. J Neuropsychiatr 8: 429–435

    Google Scholar 

  • Cooper B, Bickel H, Schäufele M (1992a) The ability of general practitioners to detect dementia and cognitive impairment in their elderly patients: a study in Mannheim. Int J Geriat Psychiatry 7: 591–598

    Google Scholar 

  • Cooper B, Bickel H, Schäufele M (1992b) Demenzerkrankungen and leichtere kognitive Beeinträchtigungen bei älteren Patienten in der ärztlichen Allgemeinpraxis. Ergebnisse einer Querschnittuntersuchung. Nervenarzt 63: 551–560

    Google Scholar 

  • Cooper B, Bickel H, Schäufele M (1996) Early development and progression of dementing illness in the elderly: a general-practice based study. Psychol Med 26: 411–419

    Google Scholar 

  • Corder EH, Saunders AM, Strittmatter WJ et al. (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families. Science 261: 921–923

    Google Scholar 

  • Council of Europe (1996) Convention for the protection of human rights and dignity of the human being with regard to the application of biology and medicine: Bioethics convention

    Google Scholar 

  • Croisile B, Trillet M, Fondarai J et al. (1993) Long-term and high-dose piracetam treatment of Alzheimer’s disease. Neurology 43: 301–305

    Google Scholar 

  • Crook T, Bartus RT, Ferris SH et al. (1986) Age-associated memory impairment: Proposed diagnostic criteria and measures of clinical change-report of a national institute of mental health work group. Dev Neuropsychol 2: 261–276

    Google Scholar 

  • Cummings JL (2000) Cholinesterase inhibitors: A new class of psychotropic compounds. Am J Psychiatry 157: 4–15

    Google Scholar 

  • Czech C, Mönning U, Tienari PJ et al. (1993) ApoE4 in clinically diagnosed Alzheimer’s disease, frontal lobe degeneration and non-dementied controls. Lancet 342: 1309–1310

    Google Scholar 

  • Czech C, Förstl H, Hentschl F, Mönning U, Besthorn C, Geiger-Kabisch C, Sattel H, Masters C, Beyreuther K (1994) Apolipoprotein E-4 gene dose in clinically diagnosed Alzheimer’s disease: prevalence, plasma cholesterol levels and cerebro-vascular change. Eur Arch Psychiatry Clin Neurosici 243: 291–292

    Google Scholar 

  • Dartigues JF, Commenges D, Letenneur L et al. (1997) Cognitive predictors of dementia in elderly community residents. Neuroepidemiology 16: 29–39

    Google Scholar 

  • Delacourte A, Buée L (1997) Normal and pathological tau proteins as factors for microtubule assembly. Int Rev Cytol 171: 167–224

    Google Scholar 

  • Devanand DP, Folz M, Gorlyn M et al. (1997b) Questionable dementia: Clinical course and predictors of outcome. J Am Geriat Soc 45: 321–328

    Google Scholar 

  • Devanand DP, Jacobs DM, Tang MX et al. (1997a) The course of psychopathology in mild to moderate Alzheimer’s disease. Arch Gen Psychiat 54: 257–263

    Google Scholar 

  • Delacourte A, Buée L, David JP et al. (1998) Lack of continuum between cerebral aging and Alzheimer’s disease as revealed by PHF-tau and Aß biochemistry. Alzheimer’s Reports 1: 101–110

    Google Scholar 

  • DGPPN (1967) Stellungnahme zum Entwurf der Bioethikrahmenkonvention des Europarates vom 8.3. 1996. Nervenarzt 67: 888–889

    Google Scholar 

  • DGPPN (1997) Die Behandlung psychischer Erkrankungen in Deutschland. Positionspapier zur aktuellen Lage und zukünftigen Entwicklung. Springer, Heidelberg

    Google Scholar 

  • Dichgans M, Mayer M, Uttner I et al. (1998) The phenotypic stectrum of CADASIL: Clinical findings in 102 cases. Ann Neurol 44: 731–739

    Google Scholar 

  • Dinkel RH (1996) Die Entwicklung der Demenz bis zum Jahr 2050. Modellrechnungen für die Bundesrepublik Deutschland unter besonderer Berücksichtigung von zukünftigem Mortalitätsfortschritt. Gesundh-Wes 58, Sonderheft 1: 50–55

    Google Scholar 

  • Donnemiller E, Heilmann J, Wenning GK et al. (1997) Brain perfusion scintigraphy with 99mTc-HMPAO or 99mTc-ECD and 123I-ß-CIT single-photon emission tomography in dementia of the Alzheimer-type and diffuse Lewy body disease. Eur J Nuclear Med 24: 319–325

    Google Scholar 

  • Ebrahim S (1999) Disability in older people: a mass problem requiring mass solutions. Lancet 353: 1990–1992

    Google Scholar 

  • Eefsting JA, Boersma F, van den Brink W, van Tilburg W (1996) Differences in prevalence of dementia based on community survey and general practitioner recognition. Psychol Med 26: 1223–1230

    Google Scholar 

  • Erkinjuntti T, (stbye T, Steenhuis R et al. (1997) The effect of different diagnostic criteria on the prevalence of dementia. N Engl J Med 337: 1667–1674

    Google Scholar 

  • Esiri M (1997) In: R Jacoby, C Oppenheimer (eds.). Psychiatry in the Elderly. Oxford: Oxford University Press

    Google Scholar 

  • EU Concerted Action (1994) Surveillance of Creutzfeldt-Jakob disease in the European community (abstract). Minutes of the second and third meeting

    Google Scholar 

  • Evans DA, Beckett LA, Field TS et al. (1997) Apolipoprotein E e4 and incidence of Alzheimer disease in a community population of older persons. J Am Med Assoc 277: 822–824

    Google Scholar 

  • Fagarasan MO, Aisen PS (1996) II-1 and anti-inflammatory drugs modulate A(3 cytotoxicity in PC12 cells. Brain Res 723: 231–234

    Google Scholar 

  • Feany MB, Dickson DW (1996) Neurodegenerative disorders with extensive tau pathology: A comparative study and review. Ann Neurol 40: 139–148

    Google Scholar 

  • Feil N (1990) Validation. Ein neuer Weg zum Verständnis alter Menschen. Wien: Delle Karth

    Google Scholar 

  • Feskens EJM, Havekes LM, Kalmijn S et al. (1994) Apolipoprotein e4 allele and cognitive decline in elderly men. British Med J 309: 1202–1206

    Google Scholar 

  • Fillit H, Weinreb H, Cholst I et al. (1986) Observations in a preliminary open trial of estradiol therapy for senile dementia — Alzheimer’s type. Psychoneuroendocrinology 11: 337–345

    Google Scholar 

  • Forette S, Seux ML, Staessen JA et al. (1998) Prevention of dementia in randomised double-blind placebo-controlled systolic hypertension in Europe ( Syst-Eur) trial. Lancet 352: 1347–1351

    Google Scholar 

  • Förstl H (1998) Alzheimer’s disease: the size of the problem, clinical manifestation and heterogeneity. J Neural Transm 54 (Suppl.): 1–8

    Google Scholar 

  • Förstl H (1999) The Lewy body variant of Alzheimer’s disease: clinical, pathophysiological and conceptual issues. Eur Arch Psychiat Clin Neurosci 249, Suppl. 3: 64–67

    Google Scholar 

  • Förstl H (2000a) Alzheimer Krankheit, Lewy-Körperchen Variante und fokal beginnende Hirnatrophien. Zur Diagnose und funktionellen Neuroanatomie. In: H Förstl (Hrsg.). Klinische Neuro-Psychiatrie. Stuttgart: Thieme, 191–215

    Google Scholar 

  • Förstl H (2000b) Clinical issues in current drug therapy for dementia. Alzheimer Dis Assoc Disord (im Druck)

    Google Scholar 

  • Förstl H, Besthorn C, Geiger-Kabisch C et al (1993) Psychotic features and the course of Alzheimer’s disease: relationship to cognitive, electroencephalographic and computerized tomography findings. Acta Psychiatr Scand 87: 395–99

    Google Scholar 

  • Förstl H, Besthorn C, Hentschel F et al. (1996) Frontal Lobe Degeneration and Alzheimer’s disease: a controlled study on clinical findings, volumetric brain changes and quantitative electroencephalography data. Dementia 7: 27–34

    Google Scholar 

  • Förstl H, Burns A, Levy R, et al. (1992b) Neurological signs in Alzheimer’s disease. Arch Neurol 49: 1038–1042

    Google Scholar 

  • Förstl H, Geiger-Kabisch C (1995) „Alzheimer-Angehörigengruppe“ — Eine systematische Erhebung von Bedürfnissen und Erfahrungen pflegender Angehöriger. Psychiat Praxis 22: 68–71

    Google Scholar 

  • Förstl H, Geiger-Kabisch C, Sattel H et al. (1996) Die Selbst-und Fremdeinschätzung klinischer Störungen bei der Alzheimer-Demenz: Ergebnisse eines strukturierten Interviews ( CAMDEX ). Fortschr Neurol Psychiatr 64: 228–233

    Google Scholar 

  • Förstl H, Hewer W (1993) Medical Morbidity in Alzheimer’s disease. In: A Bums (ed.). Ageing and Dementia. London: Edward Arnold

    Google Scholar 

  • Förstl H, Zerfass R, Geiger-Kabisch C et al. (1995) Brain atrophy in normal aging and Alzheimer’s disease: volumetric discrimination and clinical correlations. Brit J Psychiat 167: 739–46

    Google Scholar 

  • Foster NL, Wilhelmsen K, Sima AAF et al. (1997) Frontotemporal dementia and Parkinsonism linked to chromosome 17: A consensus conference. Ann Neurol 41: 706–715

    Google Scholar 

  • Fox NC, Freebourgh PA, Rossor MN (1996) Visualisation and quantification of rates of atrophy in Alzheimer’s disease. Lancet 348: 94–97

    Google Scholar 

  • Fox NC, Warrington EK, Rossor MN (1999) Serial magnetic resonance imaging of cerebral atrophy in preclinical Alzheimer’s disease. Lancet 353: 21–25

    Google Scholar 

  • Francis PT, Holmes C, Webster MT et al. (1993) Preliminary neurochemical findings in non-Alzheimer dementia due to lobar atrophy. Dementia 4: 172–177

    Google Scholar 

  • Franssen EH, Kluger A, Torossian CL et al. (1993) The neurologic syndrome of severe Alzheimer’s disease. Relationship to functional decline. Arch Neurol 50: 102–939

    Google Scholar 

  • Fratiglioni L, Ahlbom A, Viitanen M et al. (1993) Risk factors for late-onset Alzheimer’s disease: a population-based, case-control study. Ann Neurol 33: 258–266

    Google Scholar 

  • Freye R (1998) Zwischen Liebe und Überdruß. Deutsches Ärzteblatt 51/52: C 2317-C 2318

    Google Scholar 

  • Frisoni GB, Laakso MP, Beltramello A et al. (1999) Hippocampal and entorhinal cortex atrophy in frontotemporal dementia and Alzheimer’s disease. Neurology 52: 91–100

    Google Scholar 

  • Frölich L, Hampel H, Gorriz C et al. (1999) Azetylcholinesterasehemmer. In: H Förstl, H Bickel, A Kurz (Hrsg.). Alzheimer Demenz: Grundlagen, Diagnostik und Therapie. Heidelberg: Springer, 153–166

    Google Scholar 

  • Frölich L, Din A, Götz ME et al. (1998) Acetylcholine in human CSF: methodological considerations and levels in dementia of Alzheimer type. J Neural Transm 105: 961–973

    Google Scholar 

  • Fuchs T, Lauter H (1997) Kein Recht auf Tötung. Deutsches Ärzteblatt 94: A220–224

    Google Scholar 

  • Gao S, Hendrie HC, Hall KS et al. (1998) The relationships beween age, sex, and the incidence of dementia and Alzheimer disease. Arch Gen Psychaitry 55: 809–815

    Google Scholar 

  • Gertz H-J, Xuereb JH, Huppert FA et al. (1996) The relationship between clinical dementia and neuropathological staging ( Braak) in a very elderly community sample. Eur Arch Psychiatry Clin Neurosci 246: 132–136

    Google Scholar 

  • Giacobini E, Michel JP (1998) Cholinesterase inhibitors for Alzheimer disease therapy: Past, present and future. Int J Ger Psychopharmacology 1: 164–170

    Google Scholar 

  • Glass TA, de Leon MC, Marottoli RA et al. (1999) Population based study of social and productive activities as predictors of survival among elderly Americans. British Med J 319: 478–483

    Google Scholar 

  • Gnanalingham KK, Byrne EJ, Thornton A et al. (1997) Motor and cognitive function in Lewy body dementia: comparison with Alzheimer’s and Parkinson’s diseases. J Neurol Neurosurg Psychiat 62: 243–252

    Google Scholar 

  • Goldgaber D, Harris H, Hla T et al. (1989) Interleukin-1 regulates synthesis of amyloid beta protein precursor mRNA in human endothelial cell. Proc Natl Acad Sci USA 86: 7606–7610

    Google Scholar 

  • Gomez-Isla T, Price J, McKeel D et al. (1996) Profound loss of layer II entrohinal cortex neurons occurs in very mild Alzheimer’s disease. J Neurosci 16: 4491–4500

    Google Scholar 

  • Gould E, Woolley CS, Frankfurt M et al. (1990) Gonadal steroids regulate dendritic spine density in hippocmpal pyramidal cells in adulthood. J Neurosci 10: 1286–1291

    Google Scholar 

  • Grafenecker Erklärung (1996) Arbeitskreis zur Erforschung der Euthanasie-Geschichte. Dr. med. Mabuse 21: 40–43

    Google Scholar 

  • Graham JE, Rockwood K, Beattie K et al. (1997) Prevalence and severity of cognitive impairment with and without dementia in an elderly population. Lancet 349: 1793–1796

    Google Scholar 

  • Gratzl E, Bernet M, Kurz A (1998) Ratgeber in rechtlichen und finanziellen Fragen für Angehörige von Alzheimer Patienten, ehrenamtliche und professionelle Helfer. Schriftenreihe der Deutschen Alzheimer Gesellschaft e. V. Berlin

    Google Scholar 

  • Grotta JC, Norris JW, Damm B (1992) Prevention of stroke with ticlopidine: who benefits most? Neurology 42: 111–114

    Google Scholar 

  • Gsell W, Moll G, Sofic E et al. (1993) Cholinergic and monoaminergic neurotransmitter system in patients with Alzheimer’s disease and senile dementia of the Alzheimer type: A critical evaluation. In: K Maurer (Hrsg.). Dementias, Neurochemistry, Neuropathology, Neuroimaging, Neuropsychology and Genetics. Braunschweig: Vieweg, 25–51

    Google Scholar 

  • Guo Z, Fratiglioni L, Zhu L et al. (1999) Occurrence and progression of dementia in a community population aged 75 years and older. Arch Neurol 56: 991–996

    Google Scholar 

  • Hallauer JF, Schons M, Smala A et al. (1999) Defizite in der Behandlung von Patienten mit Alzheimer-Erkrankung. Psycho 25 (Sonderausgabe 1): 31–34

    Google Scholar 

  • Hänninen T, Hallikainen M, Koivisto K et al. (1995) A follow-up study of age-associated memory impairment: Neuropsychological predictors of dementia. J Am Ger Soc 43: 1007–1015

    Google Scholar 

  • Hänninen T, Koivisto K, Reinikainen KJ et al. (1996) Prevalence of ageing-associated cognitive decline in an elderly population. Age and Ageing 25: 201–205

    Google Scholar 

  • Hardy J (1997) Amyloid, the presenilins and Alzheimer’s disease. Trends Neurosci 20: 154–159

    Google Scholar 

  • Hardy J, Israel A (1999) In search of y-secretase. Nature 398: 466–467

    Google Scholar 

  • Hartmann T (1999) Intracellular biology of Alzheimer’s disease amyloid beta peptide. Eur Arch Psychiatry Clin Neurosci 249: 291–298

    Google Scholar 

  • Hartmann T, Bieger SC, Brühl B et al. (1997) Distinct sites of intracellular production for Alzheimer’s disease Aß40/42 amyloid peptides. Nat Med 3: 1016–1020

    Google Scholar 

  • Hashimoto M, Kitagaki H, Imamura T et al. (1998) Medial temporal and whole-brain atrophy in dementia with Lewy bodies. Neurology 51: 357–362

    Google Scholar 

  • Haupt M (1997) Psychotherapeutische Strategien bei kognitiven Störungen. In: H Förstl (Hrsg.). Lehrbuch der Gerontopsychiatrie. Stuttgart: Enke, 210–219

    Google Scholar 

  • Haupt M, Kurz A (1993) Predictors of nursing home placement in patients with Alzheimer’s disease. Int J Geriat Psychiatr 8: 741–746

    Google Scholar 

  • Haupt M, Kurz A, Romero B et al. (1992) Psychopathologische Störungen bei beginnender Alzheimerscher Krankheit. Fortschr Neurol Psychiat 60: 3–7

    Google Scholar 

  • Haupt M, Pollmann S, Kurz A (1991) Disoriented behaviour in familiar surroundings is strongly associated with perceptual impairment in mild Alzheimer’s disease. Dementia 2: 259–261

    Google Scholar 

  • Hellweg R (1992) „Nerve growth factor“ (NGF): pathophysiologische Bedeutung und mögliche therapeutische Konsequenzen. Nervenarzt 63: 52–56

    Google Scholar 

  • Helmchen H, Baltes MM, Geiselmann B et al (1999) Psychiatric illnesses in old age. In: PB Baltes, KU Mayer (Hrsg.). The Berlin Aging Study. Cambridge: Cambridge Univ Press, 167–196

    Google Scholar 

  • Helmchen H, Lauter H (Hrsg.; 1995 ) Dürfen Ärzte mit Demenzkranken forschen? Stuttgart: Thieme

    Google Scholar 

  • Heimchen H, Vollmann J (1999) Ethische Fragen in der Psychiatrie. In: H Helmchen, F Henn, H Lauter, N Sartorius (Hrsg.). Psychiatrie der Gegenwart, Bd. 2 (4. Auflage). Berlin: Springer, 521–577

    Google Scholar 

  • Henderson AS, Easteal S, Jorm AF et al. (1995) Apolipoprotein E allele E4, dementia and cognitive decline in a population sample. Lancet 346: 1387–1390

    Google Scholar 

  • Hénon H, Pasquier F, Durieu I et al. (1997) Preexisting dementia in stroke patients. Baseline frequency, associated factors, and outcome. Stroke 28: 2429–2436

    Google Scholar 

  • Hénon H, Pasquier F, Durieu I et al. (1998) Medial temporal lobe atrophy in stroke patients: relation to pre-existing dementia. J Neurol Neurosurg Psychiatr 65: 641–647

    Google Scholar 

  • Hettiaratchy P, Manthorpe J (1993). A carer’s group for families and patients with dementia. In: G Jones, BML Miesen (eds.). Care-Giving in Dementia. London and New York: Routledge, 419–434

    Google Scholar 

  • Heutink P, Stevens M, Rizzu P et al. (1997) Hereditary frontotemporal dementia is linked to chromosome 17q21-q22: A genetic and clinicopathological study of three Dutch families. Ann Neurol 41: 150–157

    Google Scholar 

  • Hirsch RD (1994) Psychotherapie bei Demenzen. Darmstadt: Steinkopff

    Google Scholar 

  • Hirsch R, Holler G, Reichwaldt W et al. (1999) Leitfaden für die ambulante und stationäre gerontopsychiatrische Versorgung. Schriftenreihe des Bundesministeriums für Gesundheit, Bd. 114. Baden-Baden: Nomos, 417 S.

    Google Scholar 

  • Hof PR, Bouras C, Perl DP et al. (1994) Quantitative neuropathologic analysis of Pick’s disease cases: cortical distribution of Pick bodies and coexistence with Alzheimer’s disease. Acta Neuropathol 87: 115–124

    Google Scholar 

  • Hofman A, Ott A, Breteler MMB et al. (1997) Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer’s disease in the Rotterdam study. Lancet 349: 151–154

    Google Scholar 

  • Hofmann M, Hock C, Kühler A et al. (1996) Interactive computer-based cognitive training in patients with Alzheimer’s disease. J Psychiatr Res 30: 493–501

    Google Scholar 

  • Hope T, Keene J, Fairburn CG et al. (1999) Natural history of behavioural changes and psychiatric symptoms in Alzheimer’s disease. Brit J Psychiatr 174: 39–44

    Google Scholar 

  • Hughes CP, Berg L, Danziger WL et al. (1982) A new clinical scale for the staging of dementia. Brit J Psychiatr 140: 566–572

    Google Scholar 

  • Hutton M, Lendon CL, Rizzu P et al. (1998) Association of missense and 5’-splice- site mutations in tau with the inherited dementia FTDP-17. Nature 393: 702–705

    Google Scholar 

  • Hyman BT, Trojanowski JQ (1997) Editorial on consensus recommendations for the postmortem diagnosis of Alzheimer’s disease from the National Institute on Aging and the Reagan Institute Working group on diagnostic criteria for the neuropathological assessment of Alzheimer’s disease. J Neuropathol Exp Neurol 56: 1095–1097

    Google Scholar 

  • Ihl R, Förstl H, Frölich L (2000) Praxisleitlinien in Psychiatrie and Psychotherapie. Deutsche Gesellschaft far Psychiatrie ( Hrsg.).; Psychotherapie and Nervenheilkunde

    Google Scholar 

  • Dilling H, Mombour W, Schmidt MH (eds.; 1995 ) International Classification of Diseases (Internationale Klassifikation psychischer Störungen) ICD -10 ( 2nd edition ). Bern: Hans Huber

    Google Scholar 

  • Jack CR, Petersen RC, Xu YC et al. (1999) Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment. Neurology 52: 1397–1403

    Google Scholar 

  • Jacobs DM, Sano M, Dooneief G et al. (1995) Neuropsychological detection and characterization of preclinical Alzheimer’s disease. Neurology 45: 957–962

    Google Scholar 

  • Jobst KA, Smith AD, Szatmari M et al. (1994) Rapidly progressing atrophy of medial temporal lobe in Alzheimer’s disease. Lancet 343: 829–830

    Google Scholar 

  • Jones G, Miesen BML (Hrsg.; 1993 ) Care-Giving in Dementia. London and New York: Routledge

    Google Scholar 

  • Jonker C, Schmand B, Lindeboom J et al. (1998) Association between Apolipoprotein E e4 and the rate of cognitive decline in community-dwelling elderly individuals with and without dementia. Arch Neurol 55: 1065–1069

    Google Scholar 

  • Jonkman EJ (1998) Modifications EEG au cours du viellissement normal et dans les démences de type Alzheimer. Alzheimer Actualités 130: 6–12

    Google Scholar 

  • Jorm AF, Christensen H, Korten AE et al. (1997) Do cognitive complaints either predict future cognitive decline or reflect past cognitive decline? A longitudinal study of an elderly community sample. Psychol Med 27: 91–98

    Google Scholar 

  • Jorm AF, Henderson AS, Scott R et al. (1994) Does education protect against cognitive impairment? A comparison of the elderly in two Australian cities. Int J Ger Psychiatr 9: 357–363

    Google Scholar 

  • Jorm AF, Jolley D (1998) The incidence of dementia. A meta-analysis. Neurology 51: 728–733

    Google Scholar 

  • Jorm AF, van Duijn CM, Chandra V et al. (1991) Psychiatric history and related exposures as risk factors for Alzheimer’s disease: a collaborative re-analysis of case-control studies. Int J Epidemiol 20 (Suppl.): 43–47

    Google Scholar 

  • Jost BC, Grossberg GT (1995) The natural history of Alzheimer’s disease: A brain bank study. J Am Geriat Soc 43: 1248–1255

    Google Scholar 

  • Kalmijn S, Launer LJ, Ott A et al. (1997) Dietary fat intake and the risk of incident dementia in the Rotterdam study. Ann Neurol 42: 776–782

    Google Scholar 

  • Katzman R (1993) Education and the prevalence of dementia and Alzheimer’s disease. Neurology 43: 13–20

    Google Scholar 

  • Katzman R (1997) The aging brain. Limitations in our knowledge and future approaches. Arch Neurol 54: 1201–1205

    Google Scholar 

  • Kaufer DI, Miller BL, Itti L et al. (1997) Midline cerebral morphometry distinguishes frontotemporal dementia and Alzheimer’s disease. Neurology 48: 978–985

    Google Scholar 

  • Kidron D, Black SE, Stanchev P et al. (1997) Quantitative MR volumetry in Alzheimer’s disease — Topographic markers and the effects of sex and education. Neurology 49: 1505–1512

    Google Scholar 

  • Klunk WE, Debnath ML, Pettegrew JW (1994) Development of small molecul probes for the beta-amyloid protein of Alzheimer’s disease. Neurobiol Aging 15: 691–698

    Google Scholar 

  • Knopman D, Schneider L, Davis MD et al. (1996) Long-term tacrine ( Cognex) treatment: Effects on nursing home placement and mortality. Neurology 47: 166–177

    Google Scholar 

  • Kramer AF, Hahn S, Cohen NJ et al. (1999) Ageing, fitness and neurocognitive function. Nature 400: 418–419

    Google Scholar 

  • Kuhl DE, Koeppe RA, Minoshima S et al. (1999) In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer’s disease. Neurology 52: 691–699

    Google Scholar 

  • Kurz A, Greschniok, P (1994) Überlebenswahrscheinlichkeit bei Alzheimer-Krankheit. Versicherungsmedizin 270: 59–62

    Google Scholar 

  • Kurz A, Lauter H (1999) Klinische Aspekte der Alzheimer-Krankheit. In: H Helmchen, F Henn, H Lauter, N Sartorius (Hrsg.). Psychiatrie der Gegenwart, Bd. 4 (4. Auflage). Berlin: Springer, 71–103

    Google Scholar 

  • Kurz A, Riemenschneider M, Buch K et al. (1998) Tau protein in cerebrospinal fluid is significantly increased at the earliest clinical stage of Alzheimer disease. Alzheimer Dis Assoc Disord 12: 372–377

    Google Scholar 

  • Launer LJ, Andersen K, Dewey ME et al. (1999) Rates and risk factors for dementia and Alzheimer’s disease. Results from EURODEM pooled analyses. Neurology 52: 78–84

    Google Scholar 

  • Launer Li, Festkens EJM, Kalmijn SKD (1996) Smoking, drinking and thinking. The Zutphen Elderly Study. Am J Epidemiol 143: 219–227

    Google Scholar 

  • Launer LJ, Masaki K, Petrovitch H, Foley D, Havlik RJ (1995) The association between midlife blood pressure levels and late-life cognitive function. The Honolulu-Asia Aging Study. JAMA 274: 1846–1851

    Google Scholar 

  • Lauter H (1996) Assessment and evaluation of competence to consent. In: HG Koch, S Reiter-Theil, H Helmchen (Hrsg.). Informed consent in psychiatry. Medizin in Recht und Ethik, Bd. 33. Baden-Baden: Nomos, 307–321

    Google Scholar 

  • Lauter H (1997a) Ethische Aspekte der Gerontopsychiatrie. In: H Förstl (Hrsg.). Lehrbuch der Gerontopsychiatrie. Stuttgart: Enke, 228–243

    Google Scholar 

  • Lauter H (1997b) Ärztliche Überlegungen zur aktuellen Euthanasiediskussion. In: H Csef (Hrsg.). Sinnverlust und Sinnfindung in Gesundheit und Krankheit. Würzburg: Königshausen & Neumann

    Google Scholar 

  • Lauter H (1998) Stichwort „Demenz“. In: W Korff, L Beck, P Mikat et al. (Hrsg.). Lexikon der Bioethik. Gütersloh: Gütersloher Verlagshaus, 464–468

    Google Scholar 

  • Lauter H (1999) Ärztliche Überlegungen zur aktuellen Euthanasiediskussion. In: A Barocka, E Lungershausen (Hrsg.). Ethische Brennpunkte der Psychiatrie. Würzburg: Königshausen & Neumann, 111–126

    Google Scholar 

  • Lauter H, Meyer JE (1992) Die neue Euthanasiediskussion aus psychiatrischer Sicht. Fortschr Neurol Psychiatr 60: 441–448

    Google Scholar 

  • Le Bars PL, Katz MK, Berman N et al. for the North American Egb Study Group (1997) A placebo-controlled, double-blind, randomized trial of an extract of ginkgo biloba for dementia. J Am Med Assoc 278: 1327–1332

    Google Scholar 

  • Ledésert B, Ritchie K (1994) The diagnosis and management of senile dementia in general practice: A study of 301 general practitioners in the Montpellier region. Int J Geriat Psychiatry 9: 43–46

    Google Scholar 

  • Leonard JV, Schapira AHV (2000a) Mitochondrial respiratory chain disorders I: Mitochondrial DNA defects. Lancet 355: 299–304

    Google Scholar 

  • Leonard JV, Schapira AH (2000b) Mitochondrial respiratory chain disorders II: neurodegenerative disorders and nuclear gene defects. Lancet 355: 389–394

    Google Scholar 

  • Letenneur L, Commenges RD, Dartigues JF et al. (1994) Incidence of dementia and Alzheimer’s disease in elderly community residents of south-western France. Int J Epidemiol 23: 1256–1261

    Google Scholar 

  • Letenneur L, Gilleron V, Commenges D et al. (1999) Are sex and educational level independent predictors of dementia and Alzheimer’s disease? Incidence data from the PAQUID project. J Neurol Neurosurg Psychiatry 66: 177–183

    Google Scholar 

  • Levy-Lahad E, Wasco W, Poorkaj P et al. (1995) Candidate gene for the chromosome 1 familial Alzheimer’s disease locus. Science 269: 973–977

    Google Scholar 

  • Lindsay JHR, Rockwood K (1997) The Canadian study of health and aging. Risk factors for vascular dementia. Stroke 28: 526–530

    Google Scholar 

  • Linn RT, Wolf PA, Bachman DL et al. (1995) The,preclinical phase’ of probable Alzheimer’s disease. A 13-year prospective study of the Framingham cohort. Arch Neurol 52: 485–490

    Google Scholar 

  • Lippa CF, Johnson R, Smith TW (1998) The medial temporal lobe in dementia with Lewy bodies: a comparative study with Alzheimer’s disease. Ann Neurol 43: 102–106

    Google Scholar 

  • Litvan I, Agid Y, Sastrj N et al. (1997) What are the obstacles for an accurate clinical diagnosis of Pick’s disease?- A clinicopathologic study. Neurology 49: 62–69

    Google Scholar 

  • Liu L, Gauthier L, Gauthier S (1990) Spatial disorientation in persons with early senile dementia of the Alzheimer type. Am J Occup Ther 45: 67–74

    Google Scholar 

  • Locascio JH, Growdon JH, Corkin S (1995) Cognitive test performance in detecting, staging, and tracking Alzheimer’s disease. Arch Neurol 52: 1087–1099

    Google Scholar 

  • Lopez OL, Wisniewski SR, Becker JT et al. (1999) Psychiatric medication and abnormal behavior as predictors of progression in probable Alzheimer disease. Arch Neurol 56: 1266–1272

    Google Scholar 

  • Lowe J, Dickson D (1997) Pathological diagnostic criteria for dementia associated with cortical Lewy bodies: review and proposal for a descriptive approach. J Neural Transm 51, Suppl: 111–120

    Google Scholar 

  • Lyketsos CG, Chen LS, Anthony JC (1999) Cognitive decline in adulthood: An 11.5-year follow-up of the Baltimore epidemiologic catchment area study. Am J Psychiatr 156: 58–65

    Google Scholar 

  • Ma J, Yee A, Brewer HD et al. (1994) Amyloid-associated proteins al-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer’s 0-protein into filaments. Nature 372: 92–94

    Google Scholar 

  • Mant A, Eyland EA, Pond DC, Saunders NA, Chancellor AHB (1988) Recognition of dementia in general practice: Comparison of general practitioners’ opinions with assessments using the Mini-Mental State Examination and the Blessed Dementia Rating Scale. Family Practice 5: 184–188

    Google Scholar 

  • Margolis RL, McInnis MG, Rosenblatt A et al. (1999) Trinucleotide repeat expansion and neuropsychiatric disease. Arch Gen Psychiatry 56: 1019–1030

    Google Scholar 

  • Martin JB (1999) Molecular basis of the neurodegenerative disorders. N Eng J Med 340: 1970–1980

    Google Scholar 

  • Masters CL, Beyreuther K (1998) Alzheimer’s disease. British Med J 316: 446–448

    Google Scholar 

  • Masur DM, Sliwinski M, Lipton RB et al. (1994) Neuropsychological prediction of dementia and the absence of dementia in healthy elderly persons. Neurology 44: 1427–1432

    Google Scholar 

  • Matsubara B, Hirai S, Amari M et al. (1990) Alpha-1-antichymotrypsin as a possible biochemical marker for Alzheimer-type dementia. Ann Neurol 28: 561–567

    Google Scholar 

  • Mattson MP, Cheng B, Davis D et al. (1992) Beta-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J Neurosci 12: 379–389

    Google Scholar 

  • Mattson MP, Katsutoshi F, Bruce AJ et al. (1997) Amyloid cytotoxicity and Alzheimer’s disease: roles of membrane oxidation and perturbed ion homeostasis. In: JD Brioni, MW Decker (eds.). Pharmacological Treatment of Alzheimer’s Disease: Molecular and Neurobiological Foundations. New York: Wiley-Liss, 239–286

    Google Scholar 

  • Mayeux R, Ottmann R, Maestre G et al. (1995) Synergistic effects of traumatic head injury and apolipoprotein-epsilon 4 in patients with Alzheimer’s disease. Neurology 45: 555–557

    Google Scholar 

  • McGeer PL, Kawamata T, Walker DG et al. (1993) Microglia in degenerative neurological disease. Glia 7: 84–92

    Google Scholar 

  • McGeer PL, McGeer EG (1995) The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res Rev 21: 195–218

    Google Scholar 

  • McGeer PL, McGeer EG, Kawamata T et al. (1991) Reactions of the immune system in chronic degenerative neurological diseases. Can J Neruol Sci 18: 376–379

    Google Scholar 

  • McKeith I, Byrne J (1997) Lewy-Körperchen Demenz. In: H. Förstl (Hrsg.). Lehrbuch der Gerontopsychiatrie. Stuttgart: Enke, 303–308

    Google Scholar 

  • McKeith IG, Galasko D, Kosaka K et al. (1996) Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies. Neurology 47: 1113–1124

    Google Scholar 

  • Merchant C, Tang MX, Albert S et al. (1999) The influence of smoking on the risk of Alzheimer’s disease. Neurology 52: 1408–1412

    Google Scholar 

  • Meyer JS, Rogers RL, Judd BW et al. (1988) Cognition and cerebral blood flow fluctuate together in multi-infarct dementia. Stroke 19: 163–169

    Google Scholar 

  • Meyer JS, Rogers RL, McClintic K et al. (1989) Randomized clinical trial of daily aspirin therapy in multi-infarct dementia. J Am Geriat Soc 37: 549–555

    Google Scholar 

  • Miller BL, Cummings J, Mishkin F et al. (1998) Emergence of artistic talent in frontotemporal dementia. Neurology 51: 978–981

    Google Scholar 

  • Miller BL, Ikonte C, Ponton M et al. (1997) A study of the Lund-Manchester research criteria for frontotemporal dementia: Clinical and single-photon emission CT correlations. Neurology 48: 937–942

    Google Scholar 

  • Minoshima S, Giordani B, Berent S et al. (1997) Metabolic reduction in the posterior cingulate cortex in very early Alzheimer’s disease. Ann Neurol 42: 85–93

    Google Scholar 

  • Mittelman MS, Ferris SH, Shulman E et al. (1996) A family intervention to delay nursing home placement of patients with Alzheimer Disease. A randomized controlled trial. J Am Med Assoc 276: 1725–1731

    Google Scholar 

  • Montplaisir J, Petit D, Lorrain D et al. (1995) Sleep in Alzheimer’s disease: further considerations on the role of brainstem and forebrain cholinergic populations in sleep-wake mechanisms. Sleep 18: 145–148

    Google Scholar 

  • Moore V, Wyke MA (1984) Drawing disability in patients with senile dementia. Psychol Med 14: 97–105

    Google Scholar 

  • Mori E, Hirono N, Yamashita H et al. (1997) Premorbid brain size as a determinant of reserve capacity against intellectual decline in Alzheimer’s disease. Am J Psychiatr 154: 18–24

    Google Scholar 

  • Morris JC, McKeel DW, Storandt M et al. (1991) Very mild Alzheimer’s disease: Informant-based clinical, psychometric and pathologic distinction from normal aging. Neurology 41: 469–478

    Google Scholar 

  • Müller WE (1999) Nootropika. Präklinische and klinische Bewertung. In: H Förstl, H Bickel, A Kurz (Hrsg.). Alzheimer Demenz — Grundlagen, Klinik and Therapie. Heidelberg: Springer, 191–202

    Google Scholar 

  • Müller WE, Förstl H (1999) Parmakologische and nicht-medikamentöse Behandlungsansätze der Demenz. Heidelberg: Springer (im Druck )

    Google Scholar 

  • Murgolo NJ, Brown JE, Bayne ML et al. (1996) Presenilin mutations in Alheimer’s disease: molecular models suggest a potential functional locus. Trends Pharmacol Sci 17: 389–393

    Google Scholar 

  • Myers RH, Schaefer EF, Wilson PWF et al. (1996) Apolipoprotein E c4 association with dementia in a population-based study: The Framingham study. Neurology 46: 673–677

    Google Scholar 

  • Myllykangas L, Polvikoski T, Sulkava R et al. (1999) Genetic association of a2Macroglobulin with Alzheimer’s disease in a Finnish elderly population. Ann Neurol 46: 382–390

    Google Scholar 

  • Neary D, Snowden JS, Gustafson L et al. (1998) Frontotemporal Lobar Degeneration — A consensus on clinical diagnostic criteria. Neurology 51: 1546–1554

    Google Scholar 

  • Neumann PJ, Hermann, RC, Kuntz KM et al. (1999) Cost-effectiveness of donepezil in the treatment of mild or moderate Alzheimer’s disease. Neurology 52: 1138–1145

    Google Scholar 

  • Nielsen H, Lolk A, Andersen K et al. (1999) Characteristics of elderly who develop Alzheimer’s disease during the next two years — A neuropsychological study using CAMCOG. The odense study. Int J Ger Psychiat 14: 957–963

    Google Scholar 

  • Nordberg A, Lundqvist H, Hartvig P et al. (1995) Kinetic analysis of regional (S) (-) 11 C-nicotine binding in normal and Alzheimer brains: in vivo assessment using positron emission tomography. Alzheimer Dis Assoc Disord 9: 21–27

    Google Scholar 

  • Nordberg A, Winblad B (1986) Reduced number of [3H] nicotine and [3H] acetylcholine binding sites in the frontal cortex of Alzheimer brains. Neurosci Lett 72: 115–119

    Google Scholar 

  • Notkola IL, Sulkava R, Pekkanen J et al. (1998) Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer’s disease. Neuroepidemiology 17: 14–20

    Google Scholar 

  • Nürnberger Erklärung (1996) Internationaler IPPNW-Kongress. Berliner Ärzte 2: 24

    Google Scholar 

  • O’Connor DW (1994) Mild dementia: a clinical perspective. In: FA Huppert, C Brayne, DW O’Connor (Hrsg.) Dementia and normal aging. Cambridge: Cambridge University Press, 91–117

    Google Scholar 

  • O’Connor DW, Pollitt PA, Hyde JB, Brook CPB, Reiss BB, Roth M (1988) Do gene- ral practitioners miss dementia in elderly patients? British Med J 297: 1107–1110

    Google Scholar 

  • Ohkura T, Teshima Y, Isse K et al. (1995) Estrogen increases cerebral and cerebellar blood flows in postmenopausal women. Menopause 2: 13–18

    Google Scholar 

  • Oken BS, Storzbach DM, Kaye JA (1998) The efficiency of Ginkgo biloba on cognitive function in Alzheimer disease. Arch Neurol 55: 1409–1415

    Google Scholar 

  • Olichney JM, Galasko D, Salmon DP et al. (1998) Cognitive decline is faster in Lewy body variant than in Alzheimer’s disease. Neurology 51: 351–357

    Google Scholar 

  • Ott A, Breteler MMB, de Bruyne MC et al. (1997) Atrial fibrillation and dementia in a population-based study. The Rotterdam study. Stroke 28: 316–321

    Google Scholar 

  • Ott A, Breteler MMB, Van Harskamp F et al. (1995) Prevalence of Alzheimer’s disease and vascular dementia: Association with education. The Rotterdam study. British Med J 310: 970–973

    Google Scholar 

  • Ott A, Slooter AJC, Hofman A et al. (1998) Smoking and risk of dementia and Alzheimer’s disease in a population-based cohort study: the Rotterdam study. Lancet 351: 1840–1843

    Google Scholar 

  • Otto M, Ratzka P, Wiltfang J et al. (1998) Therapeutische Ansätze bei der Creutzfeldt-Jakob-Krankheit. Deutsches Ärzteblatt 51/52: C 2319-C 2321

    Google Scholar 

  • Paganini-Hill A, Henderson VW (1994) Estrogen deficiency and risk of Alzheimer’s disease in women. Am J Epidemiol 140: 256–261

    Google Scholar 

  • Paganini-Hill A et al. (1996) Estrogen replacement therapy and risk of Alzheimer disease. Arch Intern Med 156: 2213–2217

    Google Scholar 

  • Palsson S, Aevarsson O, Skoog I (1999) Depression, cerebral atrophy, cognitive performance and incidence of dementia. Brit J Psychiatr 174: 249–253

    Google Scholar 

  • Pericak-Vance MA, Bebout JL, Gaskell PC Jr et al. (1991) Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage. Am J Hum Genet 48: 1034–1050

    Google Scholar 

  • Petersen RC, Smith GE, Ivnik RF et al. (1995) Apolipoprotein E status as a predictor of the development of Alzheimer’s disease in memory-impaired individuals. J Am Med Assoc 273: 1274–1278

    Google Scholar 

  • Pfefferbaum A, Adalsteinsson E, Spielman D et al. (1999) In vivo brain concentrations of N-acetyl compounds, creatine, and choline in Alzheimer disease. Arch Gen Psychiatry 56: 185–192

    Google Scholar 

  • Pohjasvaara T, Erkinjuntti T, Ylikoski R et al. (1998) Clinical determinants of poststroke dementia. Stroke: 75–81

    Google Scholar 

  • Politoff AL, Monson N (1996) Age versus aging in the pathogenesis of senile dementia of the Alzheimer type: electrophysiological evidence. Dementia Geriat Cogn Dis 8: 18–25

    Google Scholar 

  • Poser S, Zerr I, Schulz-Schaeffer WJ et al. (1997) Die Creutzfeldt-Jakob-Krankheit. Eine Sphinx der heutigen Neurobiologie. Dtsch Med Wschr 122: 1099–1105

    Google Scholar 

  • Pozzi D, Petracchi M, Sabe L et al. (1995) Quantified electroencephalographic correlates of neuropsychological deficits in Alzheimer’s disease. J Neuropsychiat 7: 61–67

    Google Scholar 

  • Price JL, Morris JC (1999) Tangles and plaques in nondemented aging and „preclinical“ Alzheimer’s disease. Ann Neurol 45: 358–368

    Google Scholar 

  • Rankin ED, Haut MW, Keefover RW (1992). Clinical assessment of family caregivers in dementia. Gerontologist 32: 813–821

    Google Scholar 

  • Reed T, Carmelli D, Swan GE et al. (1994) Lower cognitive performance in normal older adult male twins carrying the apolipoprotein E epsilon 4 allele. Arch Neurol 51: 1189–1192

    Google Scholar 

  • Reisberg B, Auer SR, Bonteiro I et al. (1996) Behavioral disturbances of dementia: an overview of phenomenology and methodologic concerns. Int Psychogeriat 8: 16–980

    Google Scholar 

  • Reischies FM (1997) Normales Altern and leichte Demenz. In: H. Förstl (Hrsg.). Lehrbuch der Gerontopsychiatrie. Stuttgart: Enke, 366–378

    Google Scholar 

  • Rich JB, Rasmusson DX, Folstein MF et al. (1995) Nonsteroidal anti-inflammatory drugs in Alzheimer’s disease. Neurology 45: 51–55

    Google Scholar 

  • Riedel-Heller SG, Matschinger H, Schork A et al. (1999) Do memory complaints indicate the presence of cognitive impairment? — Results of a field study. Eur Arch Psychiatry Clin Neurosci 249: 197–204

    Google Scholar 

  • Ritchie K (1998) Establishing the limits of normal cerebral ageing and senile demential. Brit J Psychiatr 173: 97–101

    Google Scholar 

  • Ritchie K, Kildea D (1995) Is senile dementia „age-related“ or „ageing-related”? — Evidence from meta-analysis of dementia prevalence in the oldest old. Lancet 346: 931–934

    Google Scholar 

  • Ritchie K, Leibovici D, Ledsert B et al. (1996) A typology of subclinical senescent cognitive disorder. Brit J Psychiatr 168: 470–476

    Google Scholar 

  • Roberts GW, Gentleman SM, Lynch A et al. (1994) Beta amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer’s disease. J Neurol Neurosurg Psychiatr 57: 419–425

    Google Scholar 

  • Rocca WA, van Duijn CM, Chandra V et al. (1991) Maternal age and Alzheimer’s disease: a collaborative re-analysis of case-control studies. Int J Epidemiol 20 (Suppl.): 21–27

    Google Scholar 

  • Rogers J, Cooper NR, Webster S et al. (1992b) Complement activation by 13-amyloid in Alzheimer’s disease. Proc Natl Acad Sci USA 89: 10,016–10,020

    Google Scholar 

  • Rogers J, Schultz J, Brachova L et al. (1992a) Complement activation and betyamyloid-mediated neurotoxicity in Alzheimer’s disease. Res Immunol 143: 624630

    Google Scholar 

  • Roman GC, Tatemichi TK, Erkinjuntti T et al. (1993) Vascular dementia: diagnostic criteria for research studies: report of the NINCDS-AIREN international workshop. Neurology 43: 250–260

    Google Scholar 

  • Romero B, Eder G (1992) Selbsterhaltungstherapie: Konzept einer neuropsychologi- schen Therapie bei Alzheimer Kranken. Z Gerontopsychol Psychiat 5: 267–282

    Google Scholar 

  • Rossor M, Alvarez XA, Barker S et al. (1998) Provisional clinical and neuroradiological criteria for the diagnosis of Pick’s disease ( Special Report ). Eur J Neurol 5: 519–520

    Google Scholar 

  • Roth M, Tym E, Mountjoy C et al. (1986) CAMDEX: A Standardised Instrument for the Diagnosis of Mental Disorders in the Elderly with Special Reference to the Early Detection of Dementia. Brit J Psychiatr 149: 698–709

    Google Scholar 

  • Rubin EH, Storandt M, Miller JP et al. (1998) A prospective study of cognitive function and onset of dementia in cognitvely healthy elders. Arch Neurol 55: 395–401

    Google Scholar 

  • Sacco RL, Benjamin EJ, Broderick JP et al. (1997) Risk factors, panel. Stroke 28: 1507–1517

    Google Scholar 

  • Sandholzer H, Breull A, Fischer GC (1999) Früherkennung and Frühbehandlung von kognitiven Funktionseinbuaen: eine Studie über eine geriatrische Vorsorgeuntersuchung im unausgelesenen Patientengut der Allgemeinpraxis. Z Gerontol Geriat 32: 172–178

    Google Scholar 

  • Sandholzer H, Stoppe, G (1996) Demenzerkrankungen in der hausärztlichen Praxis: Ergebnisse von Befragungen zur Problemerkennung. In: Wächtler C, Hirsch RD, Kortus R, Stoppe G (Hrsg.) Demenz. Die Herausforderung. Verlag Egbert Ramin, Singen, 273–278

    Google Scholar 

  • Sano M, Ernesto C, Thomas RG et al. (1997) A controlled trial of selegeline, alphatocopherol, or both as treatment for Alzheimer’s disease. N Engl J Med 336: 1216–1222

    Google Scholar 

  • Schäufele M, Bickel H, Weyerer S (1999) Predictors of mortality among demented elderly in primary care. Int J Geriat Psychiatr 14: 946–956

    Google Scholar 

  • Schmand B, Jonker C, Geerlings MI et al. (1997) Subjective memory complaints in the elderly: depressive symptoms and future dementia. Brit J Psychiatr 171: 373–376

    Google Scholar 

  • Schmand B, Jonker C, Hooijer C et al. (1996) Subjective memory complaints may announce dementia. Neurology 46: 121–125

    Google Scholar 

  • Schneider LS, Small GW, Hamilton SH, Bystritsky A, Nemeroff CB, Meyers BS (1997) Estrogen replacement and response to fluocetine in a multicenter geriatric depression trial. Fluoxetine Collaborative Study Group. Am J Geriatr Psychiatry 5: 97–106

    Google Scholar 

  • Schofield PW, Jacobs D, Marder K et al. (1997a) The validity of new memory complaints in the elderly. Arch Neurol 54: 756–759

    Google Scholar 

  • Schofield PW, Marder K, Dooneief G et al. (1997b) Association of subjective memory complaints with subsequent cognitive decline in community-dwelling elderly individuals with baseline cognitive impairment. Am J Psychiatr 154: 609–615

    Google Scholar 

  • Schreiter-Gasser U, Gasser T, Ziegler P (1994) Quantitative EEG analysis in early onset Alzheimer’s disease: Correlations with severity, clinical characteristics, visual EEG and CCT. EEG Clin Neurophysiol 90: 105–112

    Google Scholar 

  • Sherrington R, Rogaev EI, Liang Y et al. (1995) Cloning of a gene bearing missense mutation in early-onset familial Alzheimer’s disease. Nature 375: 754–760

    Google Scholar 

  • Sherwin BB (1996) Hormones, mood, and cognitive functioning in postmenopausal women. Obstet Gynecol 87 (Suppl.): 20S - 26S

    Google Scholar 

  • Simons M, Keller P, De Strooper B et al. (1998) Cholesterol depletion inhibits the generation of 13-amyloid in hippocampal neurons. Proc Natl Acad Sci USA 95: 6460–6464

    Google Scholar 

  • Sinha B, Anderson JP, Barbour R et al. (1999) Purification and cloning of amyloid precursor protein ß-secretale from human brain. Nature 402: 537–540

    Google Scholar 

  • Sjögren M, Wallin A, Edman A (1997) Symptomatological characteristics distinguish between frontotemporal dementia and vascular dementia with a dominant frontal lobe syndrome. Int J Ger Psychiatry 12: 656–661

    Google Scholar 

  • Skoog I, Hesse C, Aevarsson O et al. (1998) A population study of apoE genotype at the age of 85: Relation to dementia, cerebrovascular disease, and mortality. J Neurol Neurosurg Psychiatr 64: 37–43

    Google Scholar 

  • Sloan EP, Fenton GW (1993) EEG power spectra and cognitive change in geriatric psychiatry: a longitudinal study. EEG Clin Neurophysiol 86: 361–367

    Google Scholar 

  • Slooter AJC, Cruts M, Kalmijn S et al. (1998) Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: The Rotterdam study. Arch Neurol 55: 964–968

    Google Scholar 

  • Slooter AJC, Tang MX, van Duijn CM et al. (1997) Apolipoprotein E e4 and the risk of dementia with stroke. J Am Med Assoc 277: 818–821

    Google Scholar 

  • Small GW, Leuchter AF, Mandelkem MA et al. (1993) Clinical, neuroimaging and environmental risk differences in monozygotic female twins appearing discordant for dementia of the Alzheimer type. Arch Neurol 50: 209–219

    Google Scholar 

  • Small GW, Rabins PV, Barry PP et al. (1997) Diagnosis and treatment of Alzheimer disease and related disorders. Consensus statement of the American Association for Geriatric Psychiatry, the Alzheimer’s Association, and the American Geriatrics Society. J Am Med Assoc 278: 1363–1371

    Google Scholar 

  • Smith GS, de Leon MJ, George AE, Kluger A, Volkow ND, McRae T, Golomb J, Ferris SH, Reisberg B, Ciaravino J et al. (1992) Topography of cross-sectional and longitudinal glucose metabolic deficits in Alzheimer’s desease. Pathophysiologic implications. Arch Neurol 49: 1142–1150

    Google Scholar 

  • Snowdon DA, Greiner LH, Mortimer JA et al. (1997) Brain infarction and the clinical expression of Alzheimer disease. The nun study. J Am Med Assoc 277: 813–817

    Google Scholar 

  • Snowdon DA, Kemper SJ, Mortimer JA et al. (1996) Linguistic ability in early life and cognitive function and Alzheimer’s disease in late life. Findings from the nun study. J Am Med Assoc 275: 528–532

    Google Scholar 

  • Solfrizzi V, Panza F, Tones F et al. (1999) High monounsaturated fatty acids intake protects against age-related cocnitive decline. Neurology 52: 1563–1569

    Google Scholar 

  • Souêtre E, Thwaites RMA, Yeardley HL (1999) Economic impact of Alzheimer’s disease in the United Kingdom. Brit J Psychiatr 174: 51–55

    Google Scholar 

  • Sparks DL, Markesbery WR (1991) Altered serotonergic and choliergic synaptic markers in Pick’s disease. Arch Neurol 48: 796–799

    Google Scholar 

  • St. George-Hyslop PH, Haines JL, Farrer LA et al. (1990) Genetic linkage studies suggest that Alzheimer’s disease is not a single homogeneous disorder. Nature 347: 194–197

    Google Scholar 

  • St. George-Hyslop PH, Tanzi RE, Polinsky RJ et al. (1987) The genetic defect causing familial Alzheimer’s disease maps on chromosome 21. Science 235: 885–890

    Google Scholar 

  • Steele C, Rovner B, Chase GA et al. (1990) Psychiatric symptoms and nursing home placement of patients with Alzheimer’s disease. Am J Psychiatry 147: 1049–1051

    Google Scholar 

  • Stem Y, Tang MX, Albert MS et al (1997) Predicting time to nursing home care and death in individuals with Alzheimer disease. J Am Med Assoc 277: 806–812

    Google Scholar 

  • Stewart R (1999) Hypertension and cognitive decline. Brit J Psychiatr 174: 286–287

    Google Scholar 

  • Stewart WF, Kawas C, Corrada M et al. (1997) Risk of Alzheimer’s disease and duration of NSAID use. Neurology 48: 626–632

    Google Scholar 

  • Stoppe G, Sandholzer H (1996) Demenzerkrankungen in der hausärztlichen Praxis: Ergebnisse einer Umfrage zur Behandlung. In: Wächtler C, Hirsch RD, Kortus R, Stoppe G (Hrsg.) Demenz. Die Herausforderung. Verlag Egbert Ramin, Singen, 279–282

    Google Scholar 

  • Stoppe G, Schütze R, Kögler A et al. (1995) Cerebrovascular reactivity to acetazolamide in (senile) dementia of Alzheimer’s type: relationship to disease severity. Dementia 6: 73–82

    Google Scholar 

  • Strittmatter WJ, Weisgraber KH, Goedert M et al. (1994) Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype. Exp Neurol 125: 163–171

    Google Scholar 

  • Swan GE, DeCarli C, Miller BL et al. (1998) Association of midlife blood pressure to late-life cognitive decline and brain morphology. Neurology 51: 986–993

    Google Scholar 

  • Swartz JR, Miller BL, Lesser IM et al. (1997) Frontotemporal dementia: Treatment response to serotonin selective reuptake inhibitors. J Clin Psychiatry 58: 212–216

    Google Scholar 

  • Tang MX et al. (1996) Effect of oestrogen during menopause on risk and age at onset of Alzheimer’s disease. Lancet: 429–432

    Google Scholar 

  • Tatemichi TK, Desmond DW, Stern Y et al. (1999a) Cognitive impairment after stroke: frequency, patterns, and relationship to functional abilities. J Neurol Neurosurg Psychiatry (im Druck)

    Google Scholar 

  • Tatemichi TK, Paik M Bagiella E et al. (1993b) Dementia after stroke is a determinant of longterm survival. Ann Neurol 34: 289

    Google Scholar 

  • Teri L, Gallagher-Thompson D (1991) Cognitive-behavioural interventions for treatment of depression in Alzheimer patients. Gerontologist 31: 413–416

    Google Scholar 

  • Thal LJ (1994) Clinical trials in Alzheimer’s disease. In: RD Terry, R Katzman, KL Bick (eds.). Alzheimer’s disease. Raven, 431–444

    Google Scholar 

  • Tienari PJ, De Strooper B, Ikonen E et al. (1996) Neuronal sorting and processing of amyloid precursor protein: Implications to Alzheimer’s diesease. Cold Spring Harbor Quant. Symp. 61: 575–585

    Google Scholar 

  • Tierney MC, Szalai JP, Snow G et al. (1996) The prediction of Alzheimer disease. The role of patient and informant perceptions of cognitive deficits. Arch Neurol 53: 423–427

    Google Scholar 

  • Tierney MC, Szalai JP, Snow WG et al. (1996) Prediction of probable Alzheimer’s disease in memory-impaired patients: a prospective longitudinal study. Neurology 46: 661–665

    Google Scholar 

  • Tooyama I, Kimura H, Akiyama H et al. (1990) Reactive microglia express class I and class II major histocompatibility complex antigens in Alzheimer disease. Brain Res 523: 273–280

    Google Scholar 

  • Tournier-Lasserve E, Joutel A, Melki J et al. (1993) Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukencephalopathy maps to chromosome 19q12. Nat Genet 3: 256–259

    Google Scholar 

  • Trobe JD, Waller PF, Cook-Flannagan CA et al. (1996) Crashes and violations among drivers with Alzheimer disease. Arch Neurol 54: 411–416

    Google Scholar 

  • Tsevat J, Dawson NV, Wu AW et al. (1998) Health values of hospitalized patients 80 years or older. J Am Med Assoc 279: 371–375

    Google Scholar 

  • van Duijn CM (1996) Epidemiology of the dementia: recent develpoments and new approaches. J Neurol Neurosurg Psychiatr 60: 478–488

    Google Scholar 

  • Vandenbeele P, Fiers W (1991) Is amyloidogenesis during Alzheimer’s disease due to an IL-1/IL-6 mediated „acute-phase response“ in the brain? Immunol Today 12: 217–219

    Google Scholar 

  • Vedhara K., Cox NKM, Wilcock GK et al. (1999) Chronic stress in elderly carers of dementia patients and antibody response to influenza vaccination. Lancet 353: 627–631

    Google Scholar 

  • Visser PJ, Scheltens P, Verhey FRJ et al. (1999) Medial temporal lobe atrophy and memory dysfunction as predictors for dementia in subjects with mild cognitive impairment. J Neurol 246: 477–485

    Google Scholar 

  • Walsh JS, Welch HG, Larson EB (1990) Survival of outpatients with Alzheimer-type dementia. Ann Intern Med 113: 429–434

    Google Scholar 

  • Wang HX, Fratiglioni L, Frisoni GB et al. (1999) Smoking and the occurrence of Alzheimer’s disease: cross-sectional and longitudinal data in a population-based study. Am J Epidemiol 149: 640–644

    Google Scholar 

  • Waring SC, Rocca WA, Petersen RC et al. (1999) Postmenopausal estrogen replace- ment therapy and risk of AD. A population-based study. Neurology 52: 965–970

    Google Scholar 

  • West MJ, Coleman PD, Flood DJ et al. (1994) Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer’s disease. Lancet 344: 769–772

    Google Scholar 

  • Weyerer S, Zimber A (1997) Psychopharmakagebrauch und -missbrauch im Alter. In: Lehrbuch der Gerontopsychiatrie. Stuttgart: Enke, 453–462

    Google Scholar 

  • Whitehouse P, Price D, Struble R et al. (1982) Alzheimers disease in senile dementia: Loss of neurones in the basal forebrain. Science 215: 1237–1239

    Google Scholar 

  • WHO — World Health Organization (1993) The ICD-10 Classification of Mental and Behavioural Disorders: Diagnostic criteria for research. Geneva: WHO

    Google Scholar 

  • Winblad B, Poritis (1999) Memantine in severe dementia. Int J Geriat Psychiatr 14: 135–146

    Google Scholar 

  • Wind AW, van Staveren G, Schellevis FG, Jonker C, van Eijk JThM (1994) The validity of the judgement of general practitioners on dementia. Int J Geriat Psychiatry 9: 543–549

    Google Scholar 

  • Xu H, Gouras GK, Greenfield JP et al. (1998) Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. Nat Med 4: 447–451

    Google Scholar 

  • Yan R, Bienkowski MJ, Shuck ME et al. (1999) Membrane-anchored aspartyl protease with Alzheimer’s disease B-secretase activity. Nature 402: 533–537

    Google Scholar 

  • Yener GG, Leuchter AF, Jenden D et al. (1996) Quantitative EEG in frontotemporal dementia. Clin Electroencephalography 27: 61–68

    Google Scholar 

  • Yoshitake T, Kiyohara Y, Kato I et al. (1995) Incidence and risk factors of vascular dementia and Alzheimer’s disease in a defined elderly Japanese population. The Hisayama study. Neurology 45: 1161–1168

    Google Scholar 

  • Youngman LD, Park JY, Ames BN (1992) Protein oxidation associated with aging is reduced by dietary restriction of protein or calories. Proc Natl Acad Sci USA 89: 9112–9116

    Google Scholar 

  • Zaudig M (1995) Demenz and „leichte kognitve Beeinträchtigung“ im Alter. Diagnostik, Früherkennung and Therapie. Bern: Hans Huber

    Google Scholar 

  • Zerfaß R, Daniel S, Förstl H (1997). Grundzüge des diagnostischen Vorgehens bei Demenzverdacht. In: H. Förstl (Hrsg.). Lehrbuch der Gerontopsychiatrie. Stuttgart: Enke, 253–262

    Google Scholar 

  • Zerfaß R, Daniel S, Sattel H et al. (1997) Die Pflegebedürftigkeit Demenzkranker im Urteil von Angehörigen and Gutachtern ( Pflegeversicherung ). Psychiat Prax 24: 84–87

    Google Scholar 

Download references

Authors

Editor information

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Leske + Budrich, Opladen

About this chapter

Cite this chapter

Förstl, H., Lauter, H., Bickel, H. (2001). Ursachen und Behandlungskonzepte der Demenzen. In: Gerontopsychiatrie und Alterspsychotherapie in Deutschland. VS Verlag für Sozialwissenschaften, Wiesbaden. https://doi.org/10.1007/978-3-322-99712-8_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-322-99712-8_4

  • Publisher Name: VS Verlag für Sozialwissenschaften, Wiesbaden

  • Print ISBN: 978-3-8100-2984-3

  • Online ISBN: 978-3-322-99712-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics