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The Elderly and Breast Cancer Radiotherapy

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Breast Cancer and Molecular Medicine

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References

  1. Breast Cancer Facts and Figures 2003 (American Cancer Society) at http://www.cancer.org/downloads/STT/CAFF2003BrFPWSecured.pdf

    Google Scholar 

  2. Silliman RA, Balducci L, Goodwin JS, Holmes FF, Leventhal EA. Breast cancer care in old age: what we know, don’t know, and do. J Natl Cancer Inst 1993: 85:190–199

    Article  PubMed  CAS  Google Scholar 

  3. Trimble EL, Carter CL, Cain D, Freidlin B, Ungerleider RS, Friedman MA. Representation of older patients in cancer treatment trials. Cancer 1994: 74(Suppl):2208–2214

    Article  PubMed  CAS  Google Scholar 

  4. Gazet JC, Markopoulos C, Ford HT, Coombes RC, Bland JM, Dixon RC. Prospective randomized trial of tamoxifen vs surgery in elderly patients with breast cancer. Lancet 1988: I:679–681

    Article  Google Scholar 

  5. Morrow M, White J, Moughan J, Owen J, Pajak T, Sylvester J, et al. Factors predicting the use of breast-conserving therapy in stage I and II breast carcinoma. J Clin Oncol 2001: 19:2254–2262

    PubMed  CAS  Google Scholar 

  6. Farrow DC, Hunt WC, Samet JM. Geographic variation in the treatment of localized breast cancer. N Engl J Med 1992: 326:1097–1101

    Article  PubMed  CAS  Google Scholar 

  7. Lazovich D, White E, Thomas DB, et al. Underutilization of breast-conserving surgery and radiation therapy among women with stage I or II breast cancer. JAMA 1991: 226:3433–3438

    Article  Google Scholar 

  8. Busch E, Kemeny M, Fremgen A, et al. Patterns of breast cancer care in the elderly. Cancer 1996: 78:101–111

    Article  PubMed  CAS  Google Scholar 

  9. Ballard-Barbash R, Potosky AL, Harlan LC, Nayfield SG, Kessler LG. Factors associated with surgical and radiation therapy for early stage breast cancer in older women. J Natl Cancer Inst 1996: 88:716–726

    Article  PubMed  CAS  Google Scholar 

  10. Wanebo HJ, Cole B, Chung M, Vezeridis M, Schepps B, Fulton J, et al. Is surgical management compromised in elderly patients with breast cancer? Ann Surg 1997: 225:579–589

    Article  PubMed  CAS  Google Scholar 

  11. Yancik R, Wesley MN, Ries LAG, Havlik RJ, Edwards BK, Yates JW. Effect of age and comorbidity in postmenopausal breast cancer patients aged 55 years and older. JAMA 2001: 285:885–892

    Article  PubMed  CAS  Google Scholar 

  12. National vital statistics reports volume 51 #3 Dec. 19 2002. Life Expectancy national center for health statistics US department of health and human services centers for disease control and prevention, Table 11

    Google Scholar 

  13. Satariano, WA, Ragland DR. The effect of comorbidity on 3-year survival of women with primary breast cancer. Ann Intern Med 1994: 120:104–110

    PubMed  CAS  Google Scholar 

  14. Extermann M. Measuring comorbidity in older cancer patients. Eur J Cancer 200: 36:453–471

    Google Scholar 

  15. Diab SG, Elledgr RM, Clark GM. Tumor characteristics and clinical outcome of elderly women with breast cancer. J Natl Cancer Inst 2000: 92:550–556

    Article  PubMed  CAS  Google Scholar 

  16. Clark GM, Osborne CK, McGuire WL. Correlations between estrogen receptor, progesterone receptor, and patient characteristics in human breast cancer. J Clin Oncol 1984: 2:1102–1109

    PubMed  CAS  Google Scholar 

  17. Wenger CR, Beardslee S, Owens MA, Pounds G, Oldaker T, Vendely P, et al. DNA ploidy, S-phase, and steroid receptors in more than 127 000 breast cancer patients. Breast Cancer Res Treat 1993: 28:9–20

    Article  PubMed  CAS  Google Scholar 

  18. Clark RM, Whelan T, Levine M, Roberts R, Willan A, McCulloch P, Lipa M, Wilkinson RH, Mahoney LJ. Randomized clinical trial of breast irradiation following lumpectomy and axillary dissection for node-negative breast cancer: an update. Ontario Clinical Oncology Group. J Natl Cancer Inst 1996: 88:1659–1664

    Article  PubMed  CAS  Google Scholar 

  19. Liljegren L, Holmberg J, Bergh A, Lindgren L, Tabar L, Nordgren H, Adami HO, and the Uppsala-Orebro Breast Cancer Study Group. 10-year results after sector resection with or without postoperative radiotherapy for stage I breast cancer: A randomized trial. J Clin Oncol 1999: 17:2326–2333

    PubMed  CAS  Google Scholar 

  20. Fisher ER, Anderson S, Tan-Chiu E, Fisher B, Eaton L, Wolmark N. Fifteen-year prognostic discriminants for invasive breast carcinoma: National Surgical Adjuvant Breast and Bowel Project Protocol-06. Cancer 2001 Apr 15: 91(8 Suppl):1679–1687

    Article  PubMed  CAS  Google Scholar 

  21. Bartelink H, Horiot JC, Poortmans P, Struikmans H, Van den Bogaert W, Barillot I, et al. Recurrence rates after treatment of breast cancer with standard radiotherapy with or without additional radiation. N Engl J Med 2001: 345(19):1378–1387

    Article  PubMed  CAS  Google Scholar 

  22. Whelan T, Mackenzie R, Julian J, Levine M, Shelley W, Grimard L, et al. Randomized trial of breast irradiation schedules after lumpectomy with lymph node-negative breast cancer. J Natl Cancer Inst 2002: 94:1143–1150

    PubMed  Google Scholar 

  23. Carter, KJ, Ritchey NP, Castro F, Caccamo LP, Kessler E, Erickson BA, Gawdyda, LM. Treatment of early-stage breast cancer in the elderly: A health-outcome-based approach. Med Decis Making 1998: 18:213–219

    PubMed  CAS  Google Scholar 

  24. Punglia RS, Kuntz KM, Lee JH, Recht A. Radiation therapy plus tamoxifen versus tamoxifen alone after breast-conserving surgery in postmenopausal women with stage I breast cancer: a decision analysis. J Clin Oncol 2003: 21:2260–2267

    Article  PubMed  CAS  Google Scholar 

  25. Palda VA, Llewellyn-Thomas HA, Makenzie RG, Pritchard, KI, Naylor CD. Breast cancer patients’ attitudes about rationing postlumpectomy radiation therapy: Applicability of trade-off methods to policy-making. J Clin Oncol 1997: 15:3192–3200

    PubMed  CAS  Google Scholar 

  26. Whelan TJ, Levine MN, Gafni A, Lukka H, Mohide EA, Patel M, Streiner DL. Breast irradiation post-lumpectomy: development and evaluation of a decision instrument. J Clin Oncol 1995: 13:847–853

    PubMed  CAS  Google Scholar 

  27. Whelan T, Levine M, Gafni A, Sanders K, Willan A, Mirsky D, Schnider D, McCready D, Reid S, Kobylecky A, Reed K. Mastectomy or lumpectomy? Helping women make informed choices. J Clin Oncol 1999: 17:1727–1735

    PubMed  CAS  Google Scholar 

  28. Whelan TJ, Sawka C, Levine M, Gafni A, Reyno L, Willan A, Julian J, Dent S, Abu-Zahra H, Chouinard E, Tozer R, Pritchard K, Bodendorfer I. Helping patients make informed choices: A randomized trial of a decision aid for adjuvant chemotherapy in lymph nodenegative breast cancer. J Natl Cancer Inst 2003: 95:581–587

    Article  PubMed  Google Scholar 

  29. Degner LF, Kristjanson LJ, Bowman D, Sloan JA, Carriere KC, O’Neil J, Bilodeau B, Watson P, Mueller B. Information needs and decisional preferences in women with breast cancer. JAMA. 1997: 277(18):1485–1492

    Article  PubMed  CAS  Google Scholar 

  30. Petrisek AC, Laliberte LL, Allen SM, Mor V. The treatment decision-making process: age differences in a sample of women recently diagnosed with nonrecurrent, early-stage breast cancer. Gerontologist 1997: 37:598–608

    PubMed  CAS  Google Scholar 

  31. Sandison AJP, Gold DM, Wright P, Jones PA. Breast conservation or mastectomy: treatment choice of women aged 70 years and older. Br J Surg 1996: 83:994–996

    Article  PubMed  CAS  Google Scholar 

  32. Fisher B, Anderson S, Bryant J, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 2002: 347:1233–1241

    Article  PubMed  Google Scholar 

  33. Veronesi U, Cascinelli N, Mariani L, et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med 2002: 347:1227–1232

    Article  PubMed  Google Scholar 

  34. Sarrazin D, Le MG, Arriagada R, et al. Ten-year results of a randomized trial comparing a conservative treatment to mastectomy in early breast cancer. Radiother Oncol 1989: 14:177–184

    Article  PubMed  CAS  Google Scholar 

  35. Blichert-Toft RC, Andersen JA, Overgaard M, Axelsson CK, Andersen KW, Mouridsen HT. Danish randomized trial comparing breast conservation therapy with mastectomy: six years of life-table analysis. J Natl Cancer Inst Monogr 1992: 11:19–25

    PubMed  Google Scholar 

  36. van Dongen JA, Bartelink H, Fentiman IS, et al. Randomized clinical trial to assess the value of breast-conserving therapy in stage I and II breast cancer, EORTC 10801 Trial. J Natl Cancer Inst Monogr 1992: 11:15–18

    PubMed  Google Scholar 

  37. Lichter AS, Lippman ME, Danforth JR, et al. Mastectomy versus breast-conserving therapy in the treatment of stage I and II carcinoma of the breast: a randomized trial at the National Cancer Institute. J Clin Oncol 1992: 10:976–983

    PubMed  CAS  Google Scholar 

  38. Early Breast Cancer Trialists’ Collaborative Group. Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: an overview of the randomised trials. Lancet 2000: 355:1757–1770

    Article  Google Scholar 

  39. Morris AD, Morris RD, Willson JF, et al. Breast-conserving therapy vs. mastectomy in early-stage breast cancer: a meta-analysis of 10 year survival. Cancer J Sci Am 1997: 3:6–12

    PubMed  CAS  Google Scholar 

  40. Veronesi U, Marubini E, Mariani L, Galimberti V, Luini A, Veronesi P, et al. Radiotherapy after breast-conserving surgery in small breast carcinoma: long-term results of a randomized trial. Ann Oncol 2001: 12:997–1003

    Article  PubMed  CAS  Google Scholar 

  41. Forest AP, Stewart HJ, Everington D, Prescott RJ, McArdle CS, Harnett AN. Randomised controlled trial of conservation therapy for breast cancer: 6-year analysis of the Scottish trial. Lancet 1996: 348:708–713

    Article  Google Scholar 

  42. Holli K, Saaristo R, Isola J, Joensuu H, Hakama M. Lumpectomy with or without postoperative radiotherapy of breast cancer with favourable prognostic features: results of a randomized study. Br J Cancer 2001: 84(2):164–169

    Article  PubMed  CAS  Google Scholar 

  43. Fisher B, Bryant J, Dignam JJ, Wickerham DL, Mamounas EP, Fisher ER, et al. Tamoxifen, radiation therapy or both for prevention of ipsilateral breast tumor recurrence after lumpectomy in women with invasive breast cancers of one centimeter or less. J Clin Oncol 2002: 20:4141–4149

    Article  PubMed  CAS  Google Scholar 

  44. Fyles A, McCready D, Manchul L, Trudeau M, Olivotto I, Merante P, et al. Preliminary results of a randomized study of tamoxifen +/− breast radiation in T1/2 NO disease in women over 50 years of age. Proc Am Soc Clin Oncol 2001: 20:24a, (abstr 92)

    Google Scholar 

  45. Hughes KS, Schnaper L, Berry D, Cirrincione C, McCormick B, Shank B, et al. Comparison of lumpectomy plus tamoxifen with and without radiotherapy (RT) in women 70 years of age or older who have clinical stage 1, estrogen receptor positive (EP+) breast carcinoma [abstract]. Proc Am Soc Clin Oncol 2001: 20:24a

    Google Scholar 

  46. Wyckoff J, Greenberg H, Sanderson R, Wallach P, Balducci L. Breast irradiation in the older woman: a toxicity study. J Am Geriatr Society 1994: 42:150–152

    CAS  Google Scholar 

  47. Santiago RJ, Wu L, Harris E, Fox K, Schultz D, Glick J, Solin LJ. Fifteen-year results of breast-conserving surgery and definitive irradiation for stage I and II breast cancer: The University of Pennsylvania experience. Int J Radiat Oncolo Biol Phys 2004: 58:233–2404

    Article  Google Scholar 

  48. Urtishak SL, Harris EE, Hwang W-T, Solin LJ. Ten-year outcomes for elderly women treated with breast-conserving surgery and definitive breast irradiation for early stage breast cancer [abstract]. Proc Am Soc Clin Oncol 2003: 22:11

    Google Scholar 

  49. Zachariah B, Balducci L, Venkattaramanabalaji GV, Casey L, Greenberg HM, Del Regato JA. Radiotherapy for cancer patients aged 80 and older: a study of effectiveness and side effects. Int J Radiat Oncol Biol Phys 1997: 39:1125–1129

    Article  PubMed  CAS  Google Scholar 

  50. Wasil T, Lichtman SM, Gupta V, Rush S. Radiation therapy in cancer patients 80 years of age and older. Am J Clin Oncol 2000: 23:526–530

    PubMed  CAS  Google Scholar 

  51. Deutsch M. Radiotherapy after lumpectomy for breast cancer in very old women. Am J Clin Oncol 2002: 25:48–49

    Article  PubMed  Google Scholar 

  52. Kunkler H, King CC, Williams IJ, Prescott RJ, Jack W. What is the evidence for a reduced risk of local recurrence with age among older patients treated by breast conserving therapy? Breast 2001: 10:464–469

    Article  PubMed  CAS  Google Scholar 

  53. Nattinger AB, Hoffmann RG, Kneusel RT, Schapira MM. Relation between appropriateness of primary therapy for early-stage breast carcinoma and increased use of breast-conserving surgery. Lancet 2000: 356:1148–1153

    Article  PubMed  CAS  Google Scholar 

  54. Lazovich D, Solomon CC, Thomas DB, Moe RE, White E. Breast conservation therapy in the United States following the 1990 National Institutes of Health Consensus Development Conference on the treatment of patients with early stage invasive breast carcinoma. Cancer 1999: 86:628–637

    Article  PubMed  CAS  Google Scholar 

  55. Romestaing P, Lehingue Y, Carrie C, Coquard R, Montbarbon X, Ardiet JM, et al. Role of 10 Gy boost in the conservative treatment of early breast cancer: results of a randomized clinical trial in Lyon, France. J Clin Oncol 1997: 15(3):677–685

    Google Scholar 

  56. Teissier E, Hery M, Ramaioli A, Lagrange JL, Curdi A, Bensadoun RJ, et al. Boost in conservative treatment: 6 years results of randomized trial [abstract]. Breast Cancer Res Treat 1998: 50:287

    Google Scholar 

  57. Vrieling C, Collette L, Fourquet A, Hoogenraad WJ, Horiot JC, Jager JJ, et al. On behalf of the EORTC Radiotherapy and Breast Cancer Cooperative Groups. The influence of the boost in breast-conserving therapy on cosmetic outcome in the EORTC “boost versus no boost” trial. Int J Radiat Oncol Biol Phys 1999: 45(3):677–685

    Article  PubMed  CAS  Google Scholar 

  58. Bartelink H. Radiotherapy to the conserved breast, chest wall, and regional nodes: is there a standard? Breast 2003: 12:475–482

    Article  PubMed  Google Scholar 

  59. Whelan TJ, Levine M, Julian J, Kirkbride P, Skingley P. The effects of radiation therapy on quality of life of women with breast carcinoma: results of a randomised trial. Ontario Clinical Oncology Group. Cancer 2000: 88:2260–2266

    Article  PubMed  CAS  Google Scholar 

  60. Yarnold J, Owen R, Ashton A, Broad B, Regan J, Bliss J, et al. Fractionation sensitivity of change in breast appearance after radiotherapy for early breast cancer: results of a phase III randomized trial. Breast Cancer Res Treat 2001: 69:230

    Google Scholar 

  61. Baillet F, Housset M, Maylin C, Boisserie G, Battahar R, Delanian S, et al. The use of a specific hypofractionated radiation therapy regimen versus classical fractionation in the treatment of breast cancer: a randomized study of 230 patients. Int J Radiat Oncol Biol Phys. 1990: 19:1131–1133

    Article  PubMed  CAS  Google Scholar 

  62. Whelan TJ. Radiation therapy for early breast cancer 2004: Radiotherapy parameters-fractionation, total dose, and nodal treatment [abstract]. Proc Am Soc Clin Oncol 2004

    Google Scholar 

  63. Hannoun-Levi JM, Courdi A, Marsiglia H, Namer M, Gerard JP. Breast cancer in elderly women: is partial breast irradiation a good alternative? Breast Cancer Res Treat 2003: 81:243–251

    Article  PubMed  CAS  Google Scholar 

  64. Ribeiro GG, Magee B, Swindell R, Harris M, Banerjee SS. The Christie Hospital breast conservation trial: an update at 8 years from inception. Clin Oncol (R Coll Radiol) 1993: 5(5):278–283

    CAS  Google Scholar 

  65. Vaidya JS, Baum M, Tobias JS, Morgan S, D’Souza D. The novel technique of delivering targeted intraoperative radiotherapy (Targit) for early breast cancer. Eur J Surg Oncol 2002: 28(4):447–454

    Article  PubMed  Google Scholar 

  66. Veronesi U, Gatti G, Luini A, Intra M, Ciocca M, Sanchez D, Zurrida S, Navarro S, Orecchia R. Full-dose intraoperative radiotherapy with electrons during breast-conserving surgery. Arch Surg 2003: 138:1253–1256

    Article  PubMed  Google Scholar 

  67. King TA, Bolton JS, Kuske RR, Fuhrman GM, Scoggins TG, Jiang XZ. Long-term results of wide-field brachytherapy as the sole method of radiation therapy after segmental mastectomy for T(is,1,2) breast cancer. Am J Surg 2000: 180:299–304

    Article  PubMed  CAS  Google Scholar 

  68. Keisch M, Vicini F, Kuske RR, Hebert M, White J, Quiet C, Arthur D, Scroggins T, Streeter O. Initial clinical experience with the MammoSite brachytherapy applicator in women with early-stage breast cancer treated with breast-conserving therapy. Int J Radiat Oncol Biol Phys 2003: 55:289–293

    Article  PubMed  Google Scholar 

  69. Vicini FA, Remouchamps V, Wallace M, Sharpe M, Fayad J, Tyburski L, Letts N, Kestin L, Edmundson G, Pettinga J, Goldstein NS, Wong J. Ongoing clinical experience utilizing 3D conformal external beam radiotherapy to deliver partial-breast irradiation in patients with early-stage breast cancer treated with breast-conserving therapy. Int J Radiat Oncol Biol Phys 2003: 57:1247–1253

    Article  PubMed  Google Scholar 

  70. Vicini FA, Kestin L, Chen P, Benitez P, Goldstein NS, Martinez A. Limited-field radiation therapy in the management of early-stage breast cancer. J Natl Cancer Inst 2003: 95(16):1205–1210

    Article  PubMed  Google Scholar 

  71. Polgar C, Sulyok Z, Fodor J, Orosz Z, Major T, Takacsi-Nagy Z, Mangel L, Somogyi A, Kasler M, Nemeth G. Sole brachytherapy of the tumor bed after conservative surgery for T1 breast cancer: five-year results of a phase I-II study and initial findings of a randomized phase III trial. J Surg Oncol 2002: 80:121–128

    Article  PubMed  Google Scholar 

  72. Whelan T, Olivotto I, Levine M, for the steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer. Clinical practice guidelines for the care and treatment of breast cancer: 6. Radiotherapy after breast-conserving surgery (Summary of the 2003 update). CMAJ 2003: 168:437–439

    PubMed  Google Scholar 

  73. Bentzen SM, Skoczylas JZ, Overgaard M, Overgaard J. Radiotherapy-related lung fibrosis enhanced by tamoxifen. J Natl Cancer Inst 1996: 88:918–922

    Article  PubMed  CAS  Google Scholar 

  74. Wazer DE, DiPetrillo T, Schmidt-Ullrich R, Weld L, Smith TJ, Marchant DJ, et al. Factors influencing cosmetic outcome and complication risk after conservative surgery and radiotherapy for early-stage breast carcinoma. J Clin Oncol 1992: 10:356–363

    PubMed  CAS  Google Scholar 

  75. Harris EER, Christensen VJ, Hwang WT, Fox K, Solin LJ. The impact of concurrent versus sequential tamoxifen and radiation therapy in breast cancer patients undergoing breast conservation treatment. J Clin Oncol 2005: 23:11–16

    Article  PubMed  CAS  Google Scholar 

  76. Pierce LJ, Hutchins L, Green SJ, Lew D, Gralow J, Livingston RB, Osborne K, Albain KS, for the Southwest Oncology Group. Sequencing of tamoxifen (TAM) and radiotherapy (RT) with breast conservation (BCT) in early stage breast cancer [abstract]. Proc Am Soc Clin Oncol 2003: 22:10

    Google Scholar 

  77. Recht A, Edge SB, Solin LJ, Robinson DS, Estabrook A, Fine RE, Fleming GF, Formenti S, Hudis C, Kirshner JJ, Krause DA, Kuske RR, Langer AS, Sledge GW, Whelan TJ, Pfister DG. Postmastectomy radiotherapy: clinical practice guidelines of the American Society of Clinical Oncology. J Clin Oncol 2001: 19:1539–1569

    PubMed  CAS  Google Scholar 

  78. Truong PT, Olivotto IA, Whelan TJ, Levine M, for the Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer. Clinical practice guidelines for the care and treatment of breast cancer: Post-mastectomy locoregional radiotherapy. CMAJ 2004: 170:1263–1273

    PubMed  Google Scholar 

  79. Ragaz J, Jackson SM, Le N, Plenderleith I, Spinelli J, Basco V, et al. Adjuvant radiotherapy and chemotherapy in node-positive premenopausal women with breast cancer. N Engl J Med 1997: 337:956–962

    Article  PubMed  CAS  Google Scholar 

  80. Overgaard M, Hansen P, Overgaard J, Rose C, Andersson M, Bach F, et al. Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. N Engl J Med 1997: 337:949–955

    Article  PubMed  CAS  Google Scholar 

  81. Overgaard M, Jensen MB, Overgaard J, Hansen PS, Rose C, Andersson M, et al. Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish breast cancer cooperative group DBCG 82c randomized trial. Lancet 1999: 353:1641–1648

    Article  PubMed  CAS  Google Scholar 

  82. Whelan TJ, Julian J, Wright J, Jadad AR, Levine ML. Does locoregional radiation therapy improve survival in breast cancer? A meta-analysis. J Clin Oncol 2000: 18:1220–1229

    PubMed  CAS  Google Scholar 

  83. Katz A, Strom EA, Buchholz TA, Thames HD, Smith CD, Jhingran A, Hortobagyi G, Buzdar AU, Theriault R, Singletary SE, McNeese MD. Locoregional recurrence patterns after mastectomy and doxorubicin-based chemotherapy: implications for postoperative irradiation. J Clin Oncol 2000: 18(15):2817–2827

    PubMed  CAS  Google Scholar 

  84. Cuzick J, Stewart H, Rutqvist L, Houghton J, Edwards R, Redmond C, Peto R, Baum M, Fisher B, Host H, et al. Cause-specific mortality in long-term survivors of breast cancer who participated in trials of radiotherapy. J Clin Oncol 1994: 12(3):447–453

    PubMed  CAS  Google Scholar 

  85. Hojris I, Overgaard M, Christensen JJ, Overgaard J. Morbidity and mortality of ischaemic heart disease in high-risk breast-cancer patients after adjuvant postmastectomy systemic treatment with or without radiotherapy: analysis of DBCG 82b and 82c randomised trials. Radiotherapy Committee of the Danish Breast Cancer Cooperative Group. Lancet 1999 Oct 23: 354(9188):1425–1430

    Article  PubMed  CAS  Google Scholar 

  86. Arriagada R, Mouriesse H, Sarrazin D, Clark RM, Deboer G. Radiotherapy alone in breast cancer. I. Analysis of tumor parameters, tumor dose and local control. Int J Radiat Oncol Biol Phys 1985: 11:1751–1757

    Article  PubMed  CAS  Google Scholar 

  87. Wu JS, Wong R, Johnston M, Bezjak A, Whelan T. Cancer Care Ontario Practice Guidelines Initiative Supportive Care Group. Meta-analysis of dose-fractionation radiotherapy trials for the palliation of painful bone metastases. Int J Radiat Oncol Biol Phys 2003: 55(3):594–605

    Article  PubMed  Google Scholar 

  88. Priestman TJ, Dunn J, Brada M, Rampling R, Baker PG. Final results of the Royal College of Radiologists trial comparing two different radiotherapy schedules in the treatment of cerebral metastases. Clin Oncol (R Coll Radiol) 1996: 8(5):308–15

    CAS  Google Scholar 

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Authors and Affiliations

  1. Hamilton Regional Cancer Center, 699 Concession St. Room 3-62, Hamilton, ON, L8V 5C2, Canada

    Timothy Whelan

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  1. Timothy Whelan
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Editors and Affiliations

  1. Dept. of Medical Oncology, Jules Bordet Institute, Boulevard de Waterloo, 215, 1000, Brussels, Belgium

    Martine J. Piccart MD, PhD  & Fatima Cardoso MD  & 

  2. Anderson Cancer Center, The University of Texas MD, 1515 Holcombe Blvd, Houston, TX, 77030-4095, USA

    Mien-Chie Hung PhD

  3. Dept. of Radiation Oncology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, Pennsylvania, 19104-4283, USA

    Lawrence J. Solin MD

  4. Dept. of Surgery, Emory University Hospital, 1364 Clifton Road NE B206, Atlanta, Georgia, 30322-1059, USA

    William C. Wood MD

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Whelan, T. (2006). The Elderly and Breast Cancer Radiotherapy. In: Piccart, M.J., Hung, MC., Solin, L.J., Cardoso, F., Wood, W.C. (eds) Breast Cancer and Molecular Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-28266-2_15

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