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Antiinfektiöse Oberflächenbeschichtung

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Ossäre Integration

Zusammenfassung

Obwohl Infektionen mehr denn je zu den wesentlichen Komplikationen orthopädischer und traumatologischer Implantate zählen, gibt es für die klinische Anwendung noch keine etablierten antibakteriellen Implantate. Antiinfektiöse Oberflächenbeschichtungen könnten die bakterielle Besiedelung der Implantate hemmen und dadurch die Infektionsraten reduzieren. Aktuelle Entwicklungen werden im folgenden Beitrag vorgestellt und diskutiert. Wesentlich ist in diesem Zusammenhang die Beachtung der Biokompatibilität, um eine sichere ossäre Integration der beschichteten Implantate nicht zu gefährden. Aufgrund der zunehmenden Häufigkeit antibiotikaresistenter Bakterien besteht zudem die Notwendigkeit der Entwicklung antibakterieller Oberflächen mit Breitspektrumwirkung, insbesondere gegen antibiotikaresistente Infektionserreger.

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Literatur

  1. Darouiche RO (2004): Treatment of infections associated with surgical implants. N Engl J Med 350:1422–1429

    Article  PubMed  CAS  Google Scholar 

  2. Gristina AG (1987): Biomaterial-Centered Infection — Microbial Adhesion Versus Tissue Integration. Science 237:1588–1595

    PubMed  CAS  Google Scholar 

  3. Zimmerli W et al. (1982): Pathogenesis of foreign body infection: description and characteristics of an animal model. J Infect Dis 146:487–497

    PubMed  CAS  Google Scholar 

  4. Gristina AG (1994): Implant failure and the immuno-incompetent fibro-inflammatory zone. Clin Orthop 298:106–118

    PubMed  Google Scholar 

  5. Zimmerli W et al. (1984): Pathogenesis of foreign body infection. Evidence for a local granulocyte defect. J Clin Invest 73:1191–1200

    Article  PubMed  CAS  Google Scholar 

  6. Al Saffar N, Revell PA (1999): Pathology at the bone-implant interfaces. J Long Term Eff Med Implants 9:23–45

    Google Scholar 

  7. Pommer A et al. (2002): Hydroxyapatite-coated Schanz pins in external fixators used for distraction osteogenesis: a randomized, controlled trial. J Bone Joint Surg Am 84-A:1162–1166

    PubMed  Google Scholar 

  8. Darouiche RO (2003): Antimicrobial approaches for preventing infections associated with surgical implants. Clin Infect Dis 36:1284–1289

    Article  PubMed  Google Scholar 

  9. Nakamoto DA et al. (1995): Use of fibrinolytic agents to coat wire implants to decrease infection. An animal model. Invest Radiol 30:341–344

    Article  CAS  Google Scholar 

  10. Darouiche RO et al. (1998): Anti-infective efficacy of antisepticcoated intramedullary nails. J Bone Joint Surg Am 80:1336–1340

    PubMed  CAS  Google Scholar 

  11. Darouiche RO et al. (1998): Antimicrobial activity of antisepticcoated orthopaedic devices. Int J Antimicrob Agents 10:83–86

    Article  PubMed  CAS  Google Scholar 

  12. DeJong ES et al. (2001): Antimicrobial efficacy of external fixator pins coated with a lipid stabilized hydroxyapatite/chlorhexidine complex to prevent pin tract infection in a goat model. J Trauma 50:1008–1014

    Article  PubMed  CAS  Google Scholar 

  13. Gollwitzer H et al. (2003): Antibacterial poly(D,L-lactic acid) coating of medical implants using a biodegradable drug delivery technology. J Antimicrob Chemother 51:585–591

    Article  PubMed  CAS  Google Scholar 

  14. Lucke M et al. (2003): Gentamicin coating of metallic implants reduces implant-related osteomyelitis in rats. Bone 32:521–531

    Article  PubMed  CAS  Google Scholar 

  15. Lucke M et al. (2003): A new model of implant related osteomyelitis in rats. J Biomed Mater Res 67B:593–602

    Article  CAS  Google Scholar 

  16. Lucke M et al. (2005): Systemic versus local application of gentamicin in prophylaxis of implant related osteomyelitis in a rat model. Bone in Druck

    Google Scholar 

  17. Garvin KL et al. (1999): Emerging antibiotic-resistant bacteria. Their treatment in total joint arthroplasty. Clin Orthop 369:110–123

    Article  PubMed  Google Scholar 

  18. Collinge CA et al. (1994): Pin tract infections: silver vs uncoated pins. Orthopedics 17:445–448

    PubMed  CAS  Google Scholar 

  19. Bodnar E (2000): The Silzone dilemma — what did we learn? J Heart Valve Dis 9:170–173

    PubMed  CAS  Google Scholar 

  20. Masse A et al. (2000): Prevention of pin track infection in external fixation with silver coated pins: clinical and microbiological results. J Biomed Mater Res 53:600–604

    Article  PubMed  CAS  Google Scholar 

  21. Gosheger G et al. (2004): Silver-coated megaendoprostheses in a rabbit model-an analysis of the infection rate and toxicological side effects. Biomaterials 25:5547–5556

    Article  PubMed  CAS  Google Scholar 

  22. Gollwitzer H et al. (2004): A biocompatible sol-gel derived titania coating for medical implants with antibacterial properties. In: Transactions 7th World Biomaterial Congress, Sydney 2004. ISBN-1 877040 19 3. Hrsg.: Australian Society for Biomaterials, Brunswick Lower, Australia

    Google Scholar 

  23. Heidenau F et al. (2005): A novel antibacterial titania coating: Metal ion toxicity and in vitro surface colonization. J Mater Sci Mater Med 16:883–888

    Article  PubMed  CAS  Google Scholar 

  24. Etienne O et al. (2004): Multilayer polyelectrolyte films functionalized by insertion of defensin: a new approach to protection of implants from bacterial colonization. Antimicrobial Agents Chemother 48:3662–3669

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Abt. für Unfall- und Wiederherstellungschirurgie Berufsgenossenschaftliche, Unfallklinik Murnau, Professor-Küntscher-Straße 8, 82418, Murnau

    H. Gollwitzer (Dr.)

  2. Department Endoprothetik und Wirbelsäulenchirurgie Klinik für Orthopädie und Unfallchirurgie, Mare Klinikum, Eckernförder Straße 219, 24119, Kiel-Kronshagen

    L. Gerdesmeyer (PD Dr.)

Authors
  1. H. Gollwitzer
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  2. L. Gerdesmeyer
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© 2006 Springer Medizin Verlag Heidelberg

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Gollwitzer, H., Gerdesmeyer, L. (2006). Antiinfektiöse Oberflächenbeschichtung. In: Ossäre Integration. Springer, Berlin, Heidelberg . https://doi.org/10.1007/978-3-540-35687-5_8

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  • DOI: https://doi.org/10.1007/978-3-540-35687-5_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-22721-2

  • Online ISBN: 978-3-540-35687-5

  • eBook Packages: Medicine (German Language)

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