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Teratocarcinogenesis and Spontaneous Parthenogenesis in Mice

  • Chapter
Differentiation and Neoplasia

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 11))

Abstract

There are several recent reviews on the biology of teratomas (Damjanov and Solter 1974; Martin 1975; Sherman and Solter 1975; Stevens 1975; Graham 1977; Jacob 1977, 1978; Mintz 1978). Most have emphasized in vitro studies of transplantable teratocarcinomas. Here the emphasis will be on studies of spontaneous and experimentally induced teratomas in mice.

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References

  • Brinster R.L.: The effect of cells transferred into the mouse blastocyst on subsequent development. J. Exp. Med. 140, 1049–1056 (1974).

    Article  PubMed  CAS  Google Scholar 

  • Damjanov I., Solter D.: Experimental teratoma. Curr. Top. Pathol. 59, 69–130 (1974).

    Article  PubMed  CAS  Google Scholar 

  • Diwan S.B., Stevens L.C.: Development of teratomas from the ectoderm of mouse egg cylinders. J. Natl. Cancer Inst. 57, 937–942 (1976).

    PubMed  CAS  Google Scholar 

  • Dunn G.R., Stevens L.C.: Determination of sex of teratomas derived from early embryos. J. Natl. Cancer Inst. 44, 99–105 (1970).

    PubMed  CAS  Google Scholar 

  • Eicher E.: Murine ovarian teratomas and parthenotes as cytogenetic tools. Cytogenet. Cell Genet. 20, 232–239 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Eppig J J., Kozak L.P., Eicher E.M., Stevens L.C.: Ovarian teratomas in mice are derived from oocytes that have completed the first meiotic division. Nature (London) 269, 517–518 (1977).

    Article  CAS  Google Scholar 

  • Graham C.F.: Teratocarcinoma cells and normal mouse embryogenesis. In: Concepts in Mammalian Embryogenesis (ed. M.I. Sherman). Cambridge, MA-London: MIT Press 1977).

    Google Scholar 

  • Illmensee K.: Reversion of malignancy and normalized differentiation of teratocarcinoma cells in chimeric mice. In: Gatlinburg Symposium on Genetic Mosaics and Chimeras in Mammals (ed. L.B. Russell), pp. 3–25. New York: Plenum Press 1978.

    Chapter  Google Scholar 

  • Illmensee K., Mintz B.: Totipotency and normal differentiation of single teratocarcinoma cells cloned by injection into blastocysts. Proc. Natl. Acad. Sci. USA 73, 549–553 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Illmensee K., Stevens L.C.: Teratomas and chimeric mice. Sci. Am. 240, 121–132 (1979).

    Article  Google Scholar 

  • Jacob F.: Mouse teratocarcinoma and embryonic antigens. Immunol. Rev. 33, 3–33 (1977).

    Article  PubMed  CAS  Google Scholar 

  • Jacob F.: Mouse teratocarcinoma and mouse embryo. The Leeuwenhoek Lecture 1977. Proc. R. Soc. London Ser. B 201, 249–270 (1978).

    CAS  Google Scholar 

  • Kleinsmith J.J., Pierce G.B.: Multipotentiality of single embryonal carcinoma cells. Cancer Res. 24, 1544–1552 (1964).

    PubMed  CAS  Google Scholar 

  • Martin G.R.: Teratocarcinomas as a model system for the study of embryogenesis and neoplasia. Rev. Cell 5, 229–243 (1975).

    CAS  Google Scholar 

  • Mintz B.: Gene expression in neoplasia and differentiation. In: The Harvey Lectures. Ser. 71, pp. 193–246. New York-London: Academic Press 1978.

    Google Scholar 

  • Mintz B., Illmensee K.: Normal genetically mosaic mice produced from malignant teratocarcinoma cells. Proc. Natl. Acad. Sci. USA 72, 3585–3589 (1975).

    Article  PubMed  CAS  Google Scholar 

  • Mintz B., Russell E.S.: Gene-induced embryological modifications of primordial germ cells in the mouse. J. Exp. Zool. 134, 207–237 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Mintz B., Cronmiller C., Custer R.P.: Somatic cell origin of teratocarcinomas. Proc. Natl. Acad. Sci. USA 75, 2834–2838 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Pierce G.B., Beals T.F.: The ultrastructure of primordial germ cells of the fetal testis and of embryonal carcinoma cells of mice. Cancer Res. 24, 1553–1567 (1964).

    PubMed  Google Scholar 

  • Pierce G.B., Dixon F.J.: Testicular teratomas I. Demonstration of teratogenesis by metamorphosis of multipotential cells. Cancer 12, 573–583 (1959a).

    CAS  Google Scholar 

  • Pierce G.B., Dixon F.J.: Testicular teratomas II. Teratocarcinoma as an ascitic tumor. Cancer 12, 584–589 (1959b).

    CAS  Google Scholar 

  • Pierce G.B., Stevens L.C., Nakane P.K.: Ultrastructural analysis of the early development of teratocarcinoma. J. Natl. Cancer Inst. 39, 755–773 (1967).

    PubMed  CAS  Google Scholar 

  • Rossant J., Papaioannou V.E.: The biology of embryogenesis. In: Concepts in Mammalian Embryogenesis (ed. M.I. Sherman), pp. 1–36. Cambridge, MA-London: MIT Press 1977.

    Google Scholar 

  • Sherman M.I., Solter D.: Teratomas and Differentiation. New York-London: Academic Press 1975.

    Google Scholar 

  • Solter D., Å kreb N., Damjanov I.: Extrauterine growth of mouse egg-cylinders results in malignant teratoma. Nature (London) 227, 503–504 (1970).

    Article  CAS  Google Scholar 

  • Stevens L.C.: Histogenesis in testicular teratomas which occur spontaneously in strain 129 mice. Proc. Am. Assoc. Cancer Res. 2, 252–253, Abstract (1957).

    Google Scholar 

  • Stevens L.C.: Studies on transplantable testicular teratomas of strain 129 mice. J. Natl. Cancer Inst. 20, 1257–1275 (1958).

    PubMed  CAS  Google Scholar 

  • Stevens L.C.: Embryology of testicular teratomas in strain 129 mice. J. Natl. Cancer Inst. 23, 1249–1295 (1959).

    PubMed  CAS  Google Scholar 

  • Stevens L.C.: Embryonic potency of embryoid bodies derived from a transplantable testicular teratoma of the mouse. Dev. Biol. 2, 285–297 (1960).

    Article  PubMed  CAS  Google Scholar 

  • Stevens L.C.: Testicular teratomas in fetal mice. J. Natl. Cancer Inst. 28, 247–268 (1962).

    PubMed  CAS  Google Scholar 

  • Stevens L.C.: Experimental production of testicular teratomas in mice. Proc. Natl. Acad. Sci. USA 52, 654–661 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Stevens L.C.: Development of resistance to teratocarcinogenesis by primordial germ cells in mice. J. Natl. Cancer Inst. 37, 859–868 (1966).

    PubMed  CAS  Google Scholar 

  • Stevens L.C.: Origin of testicular teratomas from primordial germ cells in mice. J. Natl. Cancer Inst. 38, 549–552 (1967).

    PubMed  CAS  Google Scholar 

  • Stevens L.C.: The development of teratomas from intratesticular grafts of tubal mouse eggs. J. Embryol. Exp. Morphol. 20, 329–341 (1968).

    PubMed  CAS  Google Scholar 

  • Stevens L.C.: Environmental influence on experimental teratocarcinogenesis in testes of mice. J. Exp. Zool. 174, 407–413 (1970a).

    Article  PubMed  CAS  Google Scholar 

  • Stevens L.C.: The development of transplantable teratocarcinomas from intratesticular grafts of pre-and post implantation embryos. Dev. Biol. 21, 364–382 (1970b).

    Article  PubMed  CAS  Google Scholar 

  • Stevens L.C.: Experimental production of testicular teratomas in mice of strains 129, A/He, and their F1 hybrids. J. Natl. Cancer Inst. 44, 923–929 (1970c).

    PubMed  CAS  Google Scholar 

  • Stevens L.C.: A new inbred subline of mice (129/terSv) with a high incidence of spontaneous congenital testicular teratomas. J. Natl. Cancer Inst. 50, 235–242 (1973).

    PubMed  CAS  Google Scholar 

  • Stevens L.C.: Teratocarcinogenesis and spontaneous parthenogenesis in mice. In: The Developmental Biology of Reproduction. 33rd Symp. Soc. Dev. Biol. (eds. C.L. Markert, J. Papaconstantinou), pp. 93–106. New York-London: Academic Press 1975.

    Google Scholar 

  • Stevens L.C.: Totipotent cells of parthenogenetic origin in a chimeric mouse. Nature (London) 276, 266–267 (1978).

    Article  CAS  Google Scholar 

  • Stevens L.C., Hummel K.P.: A description of spontaneous congenital testicular teratomas in strain 129 mice. J. Natl. Cancer Inst. 18, 719–748 (1957).

    PubMed  CAS  Google Scholar 

  • Stevens L.C., Little C.C.: Spontaneous testicular teratomas in an inbred strain of mice. Proc. Natl. Acad. Sci. USA 40, 1080–1087 (1954).

    Article  PubMed  CAS  Google Scholar 

  • Stevens L.C., Mackensen J.A.: Genetic and environmental influences on teratocarcinogenesis in mice. J. Natl. Cancer Inst. 27, 443–453 (1961).

    Google Scholar 

  • Stevens L.C., Varnum D.S.: The development of teratomas from parthenogenetically activated ovarian mouse eggs. Dev. Biol. 37, 369–380 (1974).

    Article  PubMed  CAS  Google Scholar 

  • Stevens L.C., Varnum D.S., Eicher E.M.: Viable chimaeras produced from normal and parthenogenetic mouse embryos. Nature (London) 269, 515–517 (1977).

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. The Jackson Laboratory, Bar Harbor, ME, 04609, USA

    L. C. Stevens

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  1. L. C. Stevens
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Editor information

Editors and Affiliations

  1. Department of Genetics and Cell Biology, University of Minnesota, 250 Biological Sciences Center, St. Paul, MN, 55108, USA

    Robert G. McKinnell

  2. Department of Anatomy, Medical College of Pennsylvania, Philadelphia, PA, 19129, USA

    Marie A. DiBerardino

  3. Department of Genetics and Cell Biology, University of Minnesota, 250 Biological Sciences Center, St. Paul, MN, 55108, USA

    Martin Blumenfeld  & Robert D. Bergad  & 

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© 1980 Springer-Verlag Berlin Heidelberg

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Stevens, L.C. (1980). Teratocarcinogenesis and Spontaneous Parthenogenesis in Mice. In: McKinnell, R.G., DiBerardino, M.A., Blumenfeld, M., Bergad, R.D. (eds) Differentiation and Neoplasia. Results and Problems in Cell Differentiation, vol 11. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-38267-6_34

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  • DOI: https://doi.org/10.1007/978-3-540-38267-6_34

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-11561-9

  • Online ISBN: 978-3-540-38267-6

  • eBook Packages: Springer Book Archive

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