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Abstract

• Hypertrichosis is the growth of hair of an excessive amount and thickness on any part of the body.

• The term is frequently confused with hirsutism, which should only be applied to women with an excessive development of hair with a male pattern distribution.

• Hypertrichosis is classified in generalized, localized, or symptomatic. All types can also be classified according to the age of onset as congenital or acquired.

• Generalized, symptomatic, and localized forms of congenital hypertrichosis are present in several genodermatoses. Localized forms may also appear in relation to underlying hamartomas.

• Generalized acquired hypertrichosis may be a paraneoplastic syndrome, such as acquired hypertrichosis lanuginosa; it may be localized, the result of association with abnormalities of the fat, muscle, bone or of the underlying hemodynamic system; or it may be related to multiple direct cutaneous traumas.

• The most frequent acquired symptomatic forms of hypertrichosis are iatrogenic.

• Long-term removal of unwanted hair is the objective.

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References

  1. Alajlan A, Shapiro J, Rivers JK et al (2005) Paradoxical hypertrichosis after laser epilation. J Am Acad Dermatol 53:85–8

    Article  PubMed  Google Scholar 

  2. Aliaga A, Armero F, Armijo M et al (1994) Sandimmun (ciclosporina A) en psoriasis crónica severa. Resultados del estudio multicéntrico español. Actas Dermosifiliogr 85:381–5

    Google Scholar 

  3. Allue-Bellosta L, Valcarce-Pérez J, García-Font M et al (1990) Hipertricosis cubital en niña de 5 años. Un diagnóstico de atención primaria. Actas Dermosifiliogr 81:879–81

    Google Scholar 

  4. Armoni M, Filk D, Schlesinger M et al (1992) Accessory nipples: any relationship to urinary tract malformation? Pediatr Dermatol 9:239–40

    Article  PubMed  CAS  Google Scholar 

  5. Augustsson A, Stierner U, Rosdahl L et al (1991) Melanocytic naevi in sun-exposed and protected skin in melanoma patients and controls. Acta Derm Venereol 71:512–17

    PubMed  CAS  Google Scholar 

  6. Ballmer-Weber BK, Inaebnit D, Brand Ch.U et al (1996) Sporadic hypomelanosis of Ito with focal hypertrichosis in a 16-month-old girl. Dermatology 193:63–4

    Google Scholar 

  7. Bardazzi F, Vincenzi C, Stinchi C et al (1994) Post erythema nodosum localized acquired hypertrichosis. J Eur Acad Dermatol Venereol 3:397–9

    Article  Google Scholar 

  8. Bégány A, Nagy-Vezekényi K (1992) Hypertrichosis lanuginosa acquisita. Acta Derm Venereol 72:18–19

    PubMed  Google Scholar 

  9. Beighton P (1970) Congenital hypertrichosis lanuginosa. Arch Dermatol 101:669–72

    Article  PubMed  CAS  Google Scholar 

  10. Boffa MJ, Reed P, Weinkove C et al (1995) Hypertrichosis as the presenting feature of porphyria cutanea tarda. Clin Exp Dermatol 20:62–4

    Article  PubMed  CAS  Google Scholar 

  11. Bondeson J, Miles AEW (1996) The hairy family of Burma: a four generation pedigree of congenital hypertrichosis lanuginosa. J Roy Soc Med 89:403–8

    CAS  PubMed  Google Scholar 

  12. Camacho F (1982) Hipertricosis e hirsutismo. In: Camacho F, Montagna W (eds) Tricologia. Trichology. Trichologie. Garsi, Madrid, pp 123–38

    Google Scholar 

  13. Camacho F (1987) Genodermatosis menos frecuentes. Displasias complejas. Defectos congénitos del desarrollo. In: Camacho F (ed) Genodermatosis: estudio epidemiológico en Andalucía Occidental. Instituto de Desarrollo Regional, Seville, pp 157–89

    Google Scholar 

  14. Camacho F (1994) Alteraciones pilosas más frecuentes en la infancia. Anal Español Pediatr 63 [Suppl 1]:87–90

    Google Scholar 

  15. Camacho F (1995) Acquired circumscribed hypertrichosis in the “costaleros” who bear the “pasos” in the Holy Week of Sevilla. Arch Dermatol 131:361–3

    Article  PubMed  CAS  Google Scholar 

  16. Camacho F (2003) Hipertricosis e hirsutismo por medicamentos. In: Fernández-Herrera J, Requena Caballero L (eds) Erupciones cutáneas medicamentosas. Signament, Barcelona, pp 215–24

    Google Scholar 

  17. Camacho F (2003) Hypertrichosis and hirsutism. In: Bologna J, Jorizzo JL, Rapini RP (eds) Dermatology, 1st edn. Mosby, London, pp 1051–9

    Google Scholar 

  18. Camacho F (2006) Tratamiento del hirsutismo. Actas Dermosifiliogr 97 [Suppl. 1]:33–44

    Google Scholar 

  19. Camacho F, González-Cámpora R (1991) Circumscribed pilary dysembryoplasia of the palms. Dermatologica 182:63–4

    PubMed  CAS  Google Scholar 

  20. Camacho F, González-Cámpora R (1998) Polythelia pilosa: a particular form of accessory mammary tissue. Dermatology 196:295–8

    Article  PubMed  CAS  Google Scholar 

  21. Camacho F, Rodríguez-Pichardo A, García-Bravo B (1992) Hipertricosis congénitas circunscritas. Monogr Dermatol 5:334–41

    Google Scholar 

  22. Cambiaghi S, Brusasco A, Tadini G et al (1994) Nevo di Becker congenito con ipoplasia mammaria ipsilaterale. G Ital Dermatol Venereol 129:169–72

    Google Scholar 

  23. Cellini A, Offidani A (1992) Familial supernumerary nipples and breasts. Dermatology 185:56–8

    PubMed  CAS  Google Scholar 

  24. Cohen PR, Kurzrock R (1995) Miscellaneous genodermatoses: Beckwith-Wiedemann syndrome, Birt-Hogg-Dube syndrome, familial atypical multiple mole melanoma syndrome, hereditary tylosis, incontinentia pigmenti, and supernumerary nipples. Dermatol Clin 13:211–29

    PubMed  CAS  Google Scholar 

  25. Davis DA, Cohen PR, George RE (1994) Cutaneous stigmata of occult spinal dysraphism. J Am Acad Dermatol 31:892–6

    PubMed  CAS  Google Scholar 

  26. Dawber RPR, Rundegren J (2003) Hypertrichosis in females applying minoxidil topical solution and in normal controls. In: Van Neste D (ed) Hair science and technology. Skinterface, Tournai, pp 343–53

    Google Scholar 

  27. Demitsu T, Manabe M, Harina N et al (2001) Hypertrichosis induced by latanoprost. J Am Acad Dermatol 44:721–3

    Article  PubMed  CAS  Google Scholar 

  28. Di Lernia V, Happle R (1997) Hypertrichosis cubiti: disappearance of a hereditary trait with age. Eur J Dermatol 7:257–8

    Google Scholar 

  29. Dikici B, Bosnak M, Dagli A et al (2002) Interpheron alpha and hypertrichosis of eyelashes. Pediatr Infect Dis J 21:448–9

    Article  PubMed  Google Scholar 

  30. Escrivá ME, Rodríguez Pichardo A , Camacho F (1994) Hipertricosis nevoide secundaria a síndrome de Servelle. Med Cut ILA 22:297–9

    Google Scholar 

  31. Ferh B, Panizzon RG, Schnyder UW (1991) Becker’s nevus and malignant melanoma. Dermatologica 182:77–80

    Google Scholar 

  32. Ferraresso M, Ghio L, Edefonti A et al (2002) Conversion from cyclosporine to tacrolimus in pediatric kidney transplant recipients. Pediatr Nephrol 17:664–7

    Article  PubMed  Google Scholar 

  33. Filosa G, Bugatti L, Ciattaglia G et al (1997) Naevus comedonicus as dermatologic hallmark of occult spinal dysraphism. Acta Derm Venereol 77:243

    PubMed  CAS  Google Scholar 

  34. Formigán M, Alsina MM, Mascaró JM et al (1992) Becker’s Nevus and ipsilateral breast hypoplasia. Androgen-receptor study in two patients. Arch Dermatol 128:992–3

    Article  Google Scholar 

  35. García-Hernández MJ, Camacho F (1998) Nevo de Becker. Diagnóstico diferencial y asociaciones. Piel 13:513–17

    Google Scholar 

  36. García-Hernández MJ, Ortega-Resinas M, Camacho F (2001) Primary multifocal localized hypertrichosis. Eur J Dermatol 11:35–7

    PubMed  Google Scholar 

  37. García-Mellado JV, Gutiérrez-Salmerón MT, SerranoOrtega S et al (1978) Polimastias. A propósito de nueve observaciones. Actas Dermosifiliogr 69:177–88

    PubMed  Google Scholar 

  38. Gata Gata I, Rodríguez-Pichardo A, Sotillo I et al (1992) Síndrome del codo piloso. A propósito de un caso. Actas Dermosifiliogr 83:660–2

    Google Scholar 

  39. Geng SW, Lei X, Toyohara JP et al (2006) Stiff skin syndrome. J Eur Acad Dermatol Venereol 20:729–32

    Article  PubMed  CAS  Google Scholar 

  40. Grosshans E (1993) Significance of polythelia. Dermatology 186:240

    PubMed  CAS  Google Scholar 

  41. Grossman MC, Cohen PR, Grossman ME (1996) Acquired eyelash trichomegaly and alopecia areata in a human immunodeficiency virus–infected patient. Dermatology 193:52–3

    PubMed  CAS  Google Scholar 

  42. Happle R (1990) Genetic defects involving the hair. In: Orfanos CE, Happle R (eds) Hair and hair diseases. Springer, Berlin Heidelberg New York, pp 325–62

    Google Scholar 

  43. Happle R (1992) Paradominant inheritance: a possible explanation for Becker’s pigmented hairy nevus. Eur J Dermatol 2:41–5

    Google Scholar 

  44. Hatta N, Takata M, Shimizu H (1995) Spontaneous disappearance of intraepidermal type VII collagen in a patient with dystrophic epidermolysis bullosa. Br J Dermatol 133:619–24

    Article  PubMed  CAS  Google Scholar 

  45. Hengge UR, Ruzicka T, Schwartz RA et al (2006) Adverse affects of topical glucocorticosteroids. J Am Acad Dermatol 54:1–15

    Article  PubMed  Google Scholar 

  46. Herranz P, Borbujo J, Martínez W et al (1994) Rubinstein-Taybi syndrome with piebaldism. Clin Exp Dermatol 19:170–2

    Article  PubMed  CAS  Google Scholar 

  47. Herrero C, Vicente A, Bruguera M et al (1993) Is hepatitis C infection a trigger of porphyria cutanea tarda? Lancet 341:788–9

    Article  PubMed  CAS  Google Scholar 

  48. Herzberg JJ (1990) Paraneoplastic changes of the hair. In: Orfanos CE, Happle R (eds) Hair and hair diseases. Springer, Berlin Heidelberg New York, pp 763–76

    Google Scholar 

  49. Hovenden AL (1993) Hypertrichosis lanuginosa acquisita associated with malignancy. Clin Dermatol 11:99–106

    Article  PubMed  CAS  Google Scholar 

  50. Howaizi M (2005) Pegylated interferon-induced eyelid and eyebrow trichomegaly during chronic hepatitis C. J Gastroenterol Hepatol 20:1945–6

    Article  PubMed  Google Scholar 

  51. Jacobo A, Almeida HL Jr, Jorge VM (2005) Congenital erythropoietic porphyria in two siblings. Dermatol Online J 11:15

    PubMed  Google Scholar 

  52. Jorquera E, Díaz-Cano SJ, Ortega M et al (1995) Guess what! Nevoid trichostasis spinulosa. Eur J Dermatol 2:165–6

    Google Scholar 

  53. Judge MR, Khaw PT, Rice NSC et al (1991) Congenital hypertrichosis lanuginosa and congenital glaucoma. Br J Dermatol 124:495–7

    Article  PubMed  CAS  Google Scholar 

  54. Kaplan MH, Sadik NS, Talmor M (1991) Acquired trichomegaly of the eyelashes: a cutaneous marker of acquired immunodeficiency syndrome. J Am Acad Dermatol 25:801–4

    PubMed  CAS  Google Scholar 

  55. Khallouf R, Fétissof F, Machet MC et al (1994) Sequestrated meningocele of the scalp: diagnostic value of hair anomalies. Pediatr Dermatol 11:315–18

    Article  PubMed  CAS  Google Scholar 

  56. Lawson DD, Moore DH, Schneider JS et al (1994) Nevus counting as a risk factor for melanoma: comparison of self-count with count by physician. J Am Acad Dermatol 31:438–44

    PubMed  CAS  Google Scholar 

  57. Lee H-W, Lee M.-W, Choi J-H et al (2005) Familial anterior cervical hypertrichosis. J Am Acad Dermatol 53:530–2

    Google Scholar 

  58. Lim HW, Mascaró JM (1995) The porphyrias and hepatocellular carcinoma. Dermatol Clin 13:135–42

    PubMed  CAS  Google Scholar 

  59. Litt JZ (2000) Drug eruption. Reference manual 2000. Parthenon Publishing, New York

    Google Scholar 

  60. Macías Flores MA, García Cruz D, Rivera H (1984) A new form of hypertrichosis inherited as an X-linked dominant trait. Hum Genet 66:66–70

    Article  PubMed  Google Scholar 

  61. Martin VG, Pellettiere EV, Gress D et al (1994) Paget’s disease in an adolescent arising in a supernumerary nipple. J Cutan Pathol 21:283–6

    Article  PubMed  CAS  Google Scholar 

  62. Mazariegos GV, Salzedas AA, Jain A et al (2001) Conversion from cyclosporine to tacrolimus in paediatric liver transplant recipient. Paediatr Drugs 3:661–72

    Article  PubMed  CAS  Google Scholar 

  63. Mehregan DA, Mehregan DR (1994) Paraneoplastic syndromes. Adv Dermatol 9:25–44

    PubMed  CAS  Google Scholar 

  64. Nakamura A, Inoue Y, Ishihara T et al (1995) Acquired coccygeal nodule due to repeated stimulation by a bicycle saddle. J Dermatol 22:365–9

    PubMed  CAS  Google Scholar 

  65. O’Toole L, Cahill M, O’Brien C (2001) Eyelid hypertrichosis associated with latanoprost is reversible. Eur J Ophthalmol 11:377–9

    PubMed  CAS  Google Scholar 

  66. Olsen E (1994) Hypertrichosis. In: Olsen E (ed) Disorders of hair growth. Diagnosis and treatment. McGraw-Hill, New York, pp 315–36

    Google Scholar 

  67. Ozdogan M, Gur G, Kadayifcilar S et al (2000) An unusual adverse effect of interferon: hypertrichosis of the eyelashes. J Interferon Cytokine Res 20:633–4

    Article  PubMed  CAS  Google Scholar 

  68. Peluso AM, Misciali C, Vinzenzi C et al (1997) Diffuse hypertrichosis during treatment with 5% topical minoxidil. Br J Dermatol 136:118–20

    Article  PubMed  CAS  Google Scholar 

  69. Peñas PF, Jones-Caballero M, Amigo A et al (1994) Cutaneous meningioma underlying congenital localized hypertrichosis. J Am Acad Dermatol 30:363–6

    PubMed  Google Scholar 

  70. Pérez Bernal AM, Camacho F (1992) Hipertricosis. Concepto y Clasificación general. Monogr Dermatol 5:315–27

    Google Scholar 

  71. Perniciario C (1995) POEMS syndrome. Semin Dermatol 14:162–5

    Google Scholar 

  72. Politi Y, Ophir J, Brenner S (1993) Cutaneous paraneoplastic syndromes. Acta Derm Venereol 73:161–70

    PubMed  CAS  Google Scholar 

  73. Poomeechaiwong S, Golitz LE (1990) Hamartomas. Adv Dermatol 5:257–88

    PubMed  CAS  Google Scholar 

  74. Pope DN, Strimling RB, Mallory SB (1994) Hypertrichosis in juvenile dermatomyositis. J Am Acad Dermatol 31:383–7

    PubMed  CAS  Google Scholar 

  75. Prose NS, Abson KG, Scher RK (1992) Disorders of the nails and hair associated with human immunodeficiency virus infection. Int J Dermatol 31:453–7

    Article  PubMed  CAS  Google Scholar 

  76. Ramos-e-Silva M, Ribeiro MC, Carneiro LV (2001) Hair removal. Clin Dermatol 19: 437–44

    Article  PubMed  CAS  Google Scholar 

  77. Reed OM, Mellette R, Fitzpatrick JE (1989) Familial cervical hypertrichosis with underlying kyphoscoliosis. J Am Acad Dermatol 20:1069–72

    PubMed  CAS  Google Scholar 

  78. Roca-Tey R, Segura García A, González Atienza J et al (1993) Acquired hypertrichosis lanuginosa and polymyositis. Int J Dermatol 32:227–8

    Article  PubMed  CAS  Google Scholar 

  79. Rosina P, Pugliarello S, Tarocco M et al (2006) Hairy elbows syndrome. Int J Dermatol 45:127–8

    Article  PubMed  Google Scholar 

  80. Ruto F, Joly P, Fusade T et al (1992) Becker naevus and malignant melanoma [Letter to the Editor]. Dermatology 184:83

    Article  PubMed  CAS  Google Scholar 

  81. Sadick NS (1993) Clinical and laboratory evaluation of AIDS trichopathy. Int J Dermatol 32:33–8

    Article  PubMed  CAS  Google Scholar 

  82. Sanchez-Estella J, Yuste M, Santos JC et al (2005) Acquired paraneoplastic hypertrichosis lanuginose. Actas Dermosifiliogr 96:459–61

    PubMed  Google Scholar 

  83. Schrode K, Huber F, Staszak J et al (2000) Outcome of quality of life assessment used in clinical trials for hirsute women treated with topical eflornithine 15% cream. Poster 239; 58th Annual Meeting of the American Academy of Dermatology, San Francisco

    Google Scholar 

  84. Sotillo I, Jorquera E (1992) Hipertricosis por drogas. Monogr Dermatol 5:328–33

    Google Scholar 

  85. Strober BE, Potash S, Grossman ME (2001) Eyelash hypertrichosis in a patient treated with topical latanoprost. Cutis 67:109–10

    PubMed  CAS  Google Scholar 

  86. Thorp M, DeMattos A, Bennett W et al (2000) The effect of conversion from cyclosporine to tacrolimus on gingival hyperplasia, hirsutisms and cholesterol. Transplantation 69:1218–20

    Article  PubMed  CAS  Google Scholar 

  87. Tomita Y (1994) The molecular genetics of albinism and piebaldism. Arch Dermatol 130:355–8

    Article  PubMed  CAS  Google Scholar 

  88. Toumbis-Ioannou E, Cohen PR (1994) Familial polythelia. J Am Acad Dermatol 30:667–8

    Article  PubMed  CAS  Google Scholar 

  89. Trattner A, Hodak E, Sagie-Lerman T et al (1991) Familial congenital anterior cervical hypertrichosis associated with peripheral sensory and motor neuropathy – a new syndrome? J Am Acad Dermatol 25:767–70

    PubMed  CAS  Google Scholar 

  90. Trevisol-Bittencourt PC, da Silva VR, Molinari MA et al (1999) Phenytoin as the first option in female epileptic patients? Arq Neuropsiquiatr 57:784–6

    PubMed  CAS  Google Scholar 

  91. Trüeb RM (2002) Causes and management of hypertrichosis. Am J Clin Dermatol 3:617–27

    Article  PubMed  Google Scholar 

  92. Urbani CE, Betti R (1994) Tessuto mammario accessorio. Revisione della letteratura e proposta di un “grading” clinico-morfologico e di una classificazione etiologica. G Ital Dermatol Venereol 129:619–26

    Google Scholar 

  93. Urbani CE, Betti R (1997) Mammo-renal and acro-mammo renal syndromes. A nosologic approach, synopsis and update. Eur J Dermatol 7:251–6

    Google Scholar 

  94. Vashi RA, Mancini AJ, Paller AS (2001) Primary generalized and localized hypertrichosis in children. Arch Dermatol 137:877–84

    PubMed  CAS  Google Scholar 

  95. Vélez M, Cisneros JL (2000) Fundamentos de la fotodepilación. In: Cisneros JL, Camacho F (eds) Láser y fuentes de luz pulsada intensa en dermatología y dermocosmética. Grupo Aula Médica, Madrid, pp 175–90

    Google Scholar 

  96. Ward KM, Barnett C, Fox LP et al (2006) Eyelash trichomegaly associated with systemic tacrolimus. Arch Dermatol 142:248

    Article  PubMed  Google Scholar 

  97. Worret W-IF, Mayerhausen W, Emslander HP (1993) Hypertrichosis lanuginosa acquisita associated with florid cutaneous papillomatosis. Int J Dermatol 32:56–8

    Article  PubMed  CAS  Google Scholar 

  98. Wu JJ, Huang DB, Tyring SK (2006) Postherpetic poliosis. Arch Dermatol 42:250–1

    Article  Google Scholar 

  99. Yabe T, Furukawa M (1995) The origin of pilonidal sinus: a case report. J Dermatol 22:696–9

    PubMed  CAS  Google Scholar 

  100. Yoon TY, Kim JW (2006) Fibrous hamartoma of infancy manifesting as multiple nodules with hypertrichosis. J Dermatol 33:427–9

    Article  PubMed  Google Scholar 

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Camacho-Martίnez, F. (2008). Hypertrichosis. In: Blume-Peytavi, U., Tosti, A., Trüeb, R. (eds) Hair Growth and Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-46911-7_16

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