Abstract
Paleopathology is the study of ancient disease processes in skeletal remains using a spectrum of methods consisting of gross observation and radiological, paleohistopathological, biochemical, isotope, and DNA studies. Each of these tests carries both advantages and limitations, and almost all require the irreversible destruction of the specimen. In contrast, x-ray study is an appealing option because it can be performed without any significant damage to the specimen. According to Ragsdale, “Radiographs can be thought of as gross photographs of whole lesions and contribute much toward the orthopedic pathologist’s goal of understanding the origin, structure, and mechanism of skeletal diseases”, and “Maceration of residual gross material produces bone specimens that match radiographs precisely and are relevant to other fields, for example paleopathology…” (Chhem 2006; Ragsdale 1993). This underlines the important role of specimen radiological studies in both clinical and paleopathological investigations. Whether the radiation causes any alteration of the genetic materials of the specimen has yet to be documented scientifically.
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References
Aegerter E (1975) Orthopedics Diseases, 4th edn. Saunders, Philadelphia
Aksoy M, Camli N, Erdem S (1966) Roentgenographic bone changes in chronic iron deficiency anemia. Blood 27:677– 686
Aufderheide A, Rodriguez-Martin C (1998) The Cambridge Encyclopedia of Human Paleopathology. Cambridge University Press, Cambridge
Biesecker JL, Marcove RC, Huvos AG, Miké V (1970) Aneurysmal bone cysts. A clinical, pathological study of 66 cases. Cancer 26:615–625
Brothwell DR, Sandison AT (1967) Diseases in antiquity: a survey of the diseases, injuries, and surgery of early populations. Charles C. Thomas, Springfield
Brower AC, Flemmings DJ (1997) Arthritis in Black and White. Saunders, Philadelphia
Caffey J (1937) The skeletal changes in the chronic hemolytic anemias. Am J Roentgenol Radium Ther Nucl Med 37:293–324
Chapman S, Nakielny R (2003) Aids to Radiological Differential Diagnosis, 4th edn. Saunders, Edinburgh
Chhem RK (2006) Paleoradiology: imaging disease in mummies and ancient skeletons. Skeletal Radiol 35:803–804
Chhem RK, Ruhli FJ (2004) Paleoradiology: current status and future challenges. Can Assoc Radiol J 55:198–199
Chhem RK, Schmit P, Fauré C (2004) Did Ramesses II really have ankylosing spondylitis? A reappraisal. Can Assoc Radiol J 55:211–217
Cooney JP, Comdr EH, Crosby MC (1944) Absorptive bone changes in leprosy. Radiology 42:14
Crawford Adams J, Hamblen DL (1999) Outline of Fractures Including Joint Injuries, 11th edn. Churchill Livingstone, Edinburgh
Edeiken J, Freiberger RH, Jacobson HG, Martel W, Norman A, Resnick DL, Steinbach HL (1980) Bone Disease (Third Series) Syllabus. Professional Self-Evaluation and Continuing Program. American College of Radiology, Chicago
Esguerra-Gomez G, Acosta E (1948) Bone and joint lesions in leprosy: a radiologic study. Radiology 50:619–631 Exner S, Bogush G, Sokiranski R (2004) Cribra orbitalia visualized in computed tomography. Ann Anat 186:169–172
Faget GH, Mayoral A (1944) Bone changes in leprosy: a clinical and roentgenologic study of 505 cases. Radiology 42:1–13 Forrester M, Brown JC (1987) The Radiology of Joint Disease. Saunders, Philadelphia
Freiberger RH, Edeiken J, Jacobson HG, Norman A (1976) Bone Disease (Second Series) Professional Self-Evaluation and Continuing Program. American College of Radiology, Chicago
Galloway A (1999) Broken bones: anthropological analysis of blunt force trauma. Charles C. Thomas, Springfield
Greenblatt C, Spiegelman M (eds) (2003) Emerging Pathogens. Oxford University Press, Oxford
Griffith HJ (1987) Basic Bone Radiology, 2nd edn. Appleton Lange, Norwalk
Haas CJ, Zink A, Palfi G, Szeimies U, Nerlich AG (2000a) Detection of leprosy in ancient human skeletal remains by molecular identification of Mycobacterium leprae. Am J Clin Pathol 114:428–436
Haas CJ, Zink A, Molnar E, Szeimies U, Reischl U, Marcsik A, Ardagna Y, Dutour O, Pálfi G, Nerlich AG (2000b) Molecular evidence for different stages of tuberculosis in ancient bone samples from Hungary. Am J Phys Anthropol 113:293–304
Harris HA (1930) Lines of arrested growth in the long bones in childhood: the correlation of histological and radiographic appearances in clinical and experimental conditions. Br J Radiol 18:622–640
Helms AC (2005) Fundamentals of Skeletal Radiology, 3rd Edn. Philadelphia, PA
Herman B, Hummel S (2003) Ancient DNA can identify disease elements. In: Greenblatt C, Spiegelman M (eds) Emerging Pathogens. Oxford University Press, Oxford, pp 143–150
Huvos AG (1991) Bone Tumors. Diagnosis, Treatment, and Prognosis, 2nd edn. Saunders, Philadelphia
Keats TE (1988) An Atlas of Normal Developmental Roentgen Anatomy. Year Book Medical Publishers, Chicago
Lachman RS, Hooshang Taybi H (1996) Radiology of Syndromes, Metabolic Disorders, and Skeletal Dysplasias, 4th edn. Mosby, St. Louis
Laredo JD, Reizine D, Bard M, Merland JJ (1986) Vertebral Hemangiomas: Radiologic Evaluation. Radiology 161:183– 189
Lichtenstein L (1972) Bone Tumors. Mosby, Saint Louis Lovell NC (1997) Trauma in Paleopathology. Yearb Phys Anthropol 40:139–170
Madewell JE, Ragsdale BD, Sweet DE (1981) Radiologic and pathologic analysis of solitary bone lesions: part II – internal margins. Radiol Clin North Am 19:715–747
Manchester K (2002) Infection bone changes of leprosy. In: Roberts CA, Lewis ME, Manchester K (eds) The Past and Present of Leprosy: Archaeological, Historical, Paleopathological and Clinical Approaches. British Archaeological Reports International Series 1054, Archaeopress, Oxford pp 69–72
Milgram JW (1990) Radiologic and Histologic Pathology of Non Tumorous Diseases of Bones and Joints. Vol 1 and Vol 2. Northbrook Publishing, Northbrook
Moller-Christensen V (1961) Bone Changes in Leprosy. Munksgaard, Copenhagen
Ortner D J (2003) Identification of Pathological Conditions in Human Skeletal Remains, 2nd edn. Academic Press, London
Pastushyn, AI, Slin'ko E, Mirzoyeva GV (1998) Vertebral Hemangiomas: Diagnosis, management, natural history and clinicopathological correlates in 86 patients. Surg Neurol 50:535–547
Powel ML, Cook DC (2005) The Myth of Syphilis: The Natural History of Treponematosis in North America. University of Florida Press, Gainesville
Ragsdale BD (1993) Morphologic analysis of skeletal lesions: correlative of imaging studies and pathologic findings. Adv Pathol Lab Med 6:445–490
Ragsdale BD, Madewell JE, Sweet DE (1981) Radiologic and pathologic analysis of solitary bone lesions. Part II – periosteal reactions. Radiol Clin North Am 19:749–783
Reimann F, Kayhan V, Talati U, Grokmen (1975) X-ray and clinical study of the nose, sinuses and maxilla in patients with severe iron deficiency diseases. Laryngol Rhinol Otol 54:880–890
Resnick D, Kransdorf MJ (2005) Bone and Joint Imaging. Elsevier Saunders, Philadelphia
Roberts C, Manchester K (2005) The Archaeology of Disease, 3rd edn. Cornell University Press, Ithaca
Rogers J, Waldron T (1989) Infections in paleopathology: the basis of classification according to most probable cause. J Archaeol Sci 16:611–625
Rogers J, Waldron T (1995) A field guide to joint disease in archaeology. John Wiley, Chichester
Rogers J, Waldron T, Dieppe P, Watt I (1987) Arthropathies in paleopathology: the basis of classification according to most probable cause. J Archaeol Sci 14:179–193
Ruhli FJ, Chhem RK, Boni T (2004) Diagnostic paleoradiology of mummified tissue: interpretation and pitfalls. Can Assoc Radiol J 55:218–227
Schmorl G, Junghans H (1956) Clinique Radiologie de la Colonne Vertebrale Normale et Pathologique. Doin Cie, Paris
Schmorl G, Junghans H (1971) The Human Spine in Health and Disease, 2nd edn. Grune and Stratton, New York
Schultz RJ (1991) The Language of Fractures, 2nd edn. Williams and Wilkins, Baltimore
Schultz M, Roberts CA (2002) Diagnosis of leprosy in skeletons from an English later medieval hospital using histological analysis. In: Roberts CA, Lewis ME, Manchester K (eds) The Past and Present of Leprosy: Archaeological, Historical, Paleopathological and Clinical Approaches. British Archaeological Reports International Series 1054. Archaeopress, Oxford, pp 89–104
Sebes JI, Diggs LW (1979) Radiographic changes of the skull in sickle cell anemia. AJR Am J Roentgenol 132:373–377
Steinbock RT (1976a) Paleopathological Diagnosis and Interpretation: Bone Diseases in Ancient Human Populations. Charles C. Thomas, Springfield
Steinbock RT (1976b) Hematologic disorders – the anemias. In: Steinbock RT (ed) Paleopathological Diagnosis and Interpretation: Bone Diseases in Ancient Human Populations, 1st edn. Charles C. Thomas, Springfield, pp 213–248
Stuart-Macadam P (1992) Porotic hyperstosis: a new perspective. Am J Phys Anthropol 87:39–47
Sweet DE, Madewell JE, Ragsdale BD (1981) Radiologic and pathologic analysis of solitary bone lesions: part III – matrix patterns. Radiol Clin North Am 19:785–814
Walper U, Crubezy E, Schultz M (2004) Is cribra orbitalia with anemia? Analysis and interpretation of cranial pathology in Sudan. Am J Phys Anthropol 123:333–339
Zink A, Haas CJ, Reischl U, Szeimies U, Nerlich AG (2001) Molecular analysis of skeletal tuberculosis in an ancient Egyptian population. J Med Microbiol 50:355–366
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Chhem, R., Saab, G., Bohay, R. (2008). Diagnostic Paleoradiologyfor Paleopathologists. In: Paleoradiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-48833-0_4
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