Abstract
Microwave (MW) interstitial thermoablation offers several advantages over the more commonly applied thermal ablative technique of radiofrequency (RF) ablation for targeted tumor destruction, such as higher ablation temperature, faster treatment time, reduced heat-sink effect, effective ablation of cystic lesions, a technologically easier multi-applicator approach, no necessity for grounding pads, and no risk of skin burns. The technique may be used in different treatment approaches, including imagingguided percutaneous, laparoscopic, and open surgical access. MW ablation constitutes one of the most recent developments in interstitial tumor ablation techniques; however, as yet no FDA-approved commercial device is available. In MW ablation, electromagnetic MW irradiation applied to the tumor tissue causes water molecules to vibrate and rotate, resulting in tissue heating and subsequently cell death via thermal-induced protein denaturation. In first pilot studies, MW ablation has shown immense potential for the treatment of primary and secondary liver tumors, primary and secondary lung cancer, renal cell carcinoma, and bone metastases.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Deardorff DL, Diederich CJ, Nau WH (2001) Control of interstitial thermal coagulation: comparative evaluation of microwave and ultrasound applicators. Med Phys 28:104–117
Dewey WC (1994) Arrhenius relationships from the molecule and cell to the clinic. Int J Hyperthermia 10(4):457–483
Dong B, Liang P, Yu X, Su L, Yu D, Cheng Z, Zhang J (2003) Percutaneous sonographically guided microwave coagulation therapy for hepatocellular carcinoma: results in 234 patients. AJR Am J Roentgenol 180:1547–1555
Goldberg SN, Gazelle GS (2001) Radiofrequency tissue ablation: physical principles and techniques for increasing coagulation necrosis. Hepatogastroenterology 48:359–367
Goldberg SN, Gazelle GS, Dawson SL, Rittman WJ, Mueller PR, Rosenthal DI (1995) Tissue ablation with radiofrequency using multiprobe arrays. Acad Radiol 2:670–674
Goldberg SN, Hahn PF, Tanabe KK, Mueller PR, Schima W, Athanasoulis CA, Compton CC, Solbiati L, Gazelle GS (1998) Percutaneous radiofrequency tissue ablation: does perfusion-mediated tissue cooling limit coagulation necrosis? J Vasc Interv Radiol 9:101–111
Haemmerich D, Lee FT Jr (2005) Multiple applicator approaches for radiofrequency and microwave ablation. Int J Hyperthermia 21:93–106
Huber PE, Jenne JW, Rastert R et al (2001) A new noninvasive approach in breast cancer therapy using magnetic resonance imaging-guided focused ultrasound surgery. Cancer Res 61:8441–8447
Ido K, Isoda N, Sugano K (2001) Microwave coagulation therapy for liver cancer: laparoscopic microwave coagulation. J Gastroenterol 36(3):145–152
Lu MD, Chen JW, Xie XY, Liu L, Huang XQ, Liang LJ, Huang JF (2001) Hepatocellular carcinoma: US-guided percutaneous microwave coagulation therapy. Radiology 221:167–172
Matsukawa T, Yamashita Y, Arakawa A, Nishiharu T, Urata J, Murakami R, Takahashi M, Yoshimatsu S (1997) Percutaneous microwave coagulation therapy in liver tumors. A 3-year experience. Acta Radiol 38(3):410–415
Midorikawa T, Kumada K, Kikuchi H, Ishibashi K, Yagi H, Nagasaki H, Nemoto H, Saitoh M, Nakano H, Yamaguchi M, Koh Y, Sakai H, Yoshizawa Y, Sanada Y, Yoshiba M (2000) Microwave coagulation therapy for hepatocellular carcinoma. J Hepatobiliary Pancreat Surg 7:252–259
Murakami R, Yoshimatsu S, Yamashita Y, Matsukawa T, Takahashi M, Sagara K (1995) Treatment of hepatocellular carcinoma: value of percutaneous microwave coagulation. Am J Roentgenol 164:1159–1164
Ohmoto K, Miyake I, Tsuduki M, Shibata N, Takesue M, Kunieda T, Ohno S, Kuboki M, Yamamoto S (1999) Percutaneous microwave coagulation therapy for unresectable hepatocellular carcinoma. Hepatogastroenterology 46:2894–2900
Pennes HH (1948) Analysis of tissue and arterial blood temperatures in the resting human forearm. J Appl Physiol 1:93–122
Pereira PL, Trubenbach J, Schenk M, Subke J, Kroeber S, Schaefer I, Remy CT, Schmidt D, Brieger J, Claussen CD (2004) Radiofrequency ablation: in vivo comparison of four commercially available devices in pig livers. Radiology 232:482–490
Sapareto SA, Dewey WC (1984) Thermal dose determination in cancer therapy. Int J Radiat Oncol Biol Phys 10:787–800
Sato M, Watanabe Y, Ueda S, Iseki S, Abe Y, Sato N, Kimura S, Okubo K, Onji M (1996) Microwave coagulation therapy for hepatocellular carcinoma. Gastroenterology 110:1507–1514
Seki T, Wakabayashi M, Nakagawa T, Itho T, Shiro T, Kunieda K, Sato M, Uchiyama S, Inoue K (1994) Ultrasonically guided percutaneous microwave coagulation therapy for small hepatocellular carcinoma. Cancer 74:817–825
Shibata T, Iimuro Y, Yamamoto Y et al (2002) Small hepatocellular carcinoma: comparison of radio-frequency ablation and percutaneous microwave coagulation therapy. Radiology 223:331–337
Shimada S, Hirota M, Beppu T, Matsuda T, Hayashi N, Tashima S, Takai E, Yamaguchi K, Inoue K, Ogawa M (1998) Complications and management of microwave coagulation therapy for primary and metastatic liver tumors. Surg Today 28:1130–1137
Shock SA, Meredith K, Warner TF, Sampson LA, Wright AS, Winter TC 3rd, Mahvi DM, Fine JP, Lee FT Jr (2004) Microwave ablation with loop antenna: in vivo porcine liver model. Radiology 231:143–149
Simon CJ, Dupuy DE, Mayo-Smith WW (2005) Microwave ablation: principles and applications. Radiographics 25[Suppl 1]:S69–S83
Vogl TJ, Straub R, Eichler K, Woitaschek D, Mack MG (2002) Malignant liver tumors treated with MR imaging-guided laser-induced thermotherapy: experience with complications in 899 patients (2,520 lesions). Radiology 225:367–377
Wright AS, Lee FT Jr, Mahvi DM (2003) Hepatic microwave ablation with multiple antennae results in synergistically larger zones of coagulation necrosis. Ann Surg Oncol 10:275–283
Wright AS, Sampson LA, Warner TF, Mahvi DM, Lee FT Jr (2005) Radiofrequency versus microwave ablation in a hepatic porcine model. Radiology 236:132–139
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Boss, A., Dupuy, D., Pereira, P.L. (2008). Microwave Ablation. In: Vogl, T.J., Helmberger, T.K., Mack, M.G., Reiser, M.F. (eds) Percutaneous Tumor Ablation in Medical Radiology. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68250-9_3
Download citation
DOI: https://doi.org/10.1007/978-3-540-68250-9_3
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-22518-8
Online ISBN: 978-3-540-68250-9
eBook Packages: MedicineMedicine (R0)