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Intragenomic Rearrangement in TT Viruses: A Possible Role in the Pathogenesis of Disease

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TT Viruses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 331))

Abstract

A role for the ubiquitous Torque teno (TT) viruses in the pathogenesis of disease has not been resolved. In vivo and in vitro intragenomic rearrangement of TT virus genomes has been demonstrated. Replication in cell culture of a subviral molecule (411 bp) occurs through oligomerisation of RNA transcripts. Although the functions of the respective TT viral genes, as well as the newly formed genes in the rearranged subviral molecules, are largely unknown, certain similarities to genes of plant viruses of the family Geminiviridae will be described. A degree of similarity to certain cellular genes poses the question as to a role of molecular mimicry in the pathogenesis of autoimmune disease and diabetes.

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Authors and Affiliations

  1. Division for the Characterisation of Tumour Viruses, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 242, Heidelberg, 69120, Germany

    E.-M. de Villiers

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  1. E.-M. de Villiers
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  2. R. Kimmel
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  3. L. Leppik
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  4. K. Gunst
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Correspondence to E.-M. de Villiers .

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Editors and Affiliations

  1. Deutsches Krebsforschungszentrum Abt., Tumorvirus-Charakterisierung, Im Neuenheimer Feld 242, Heidelberg, 69120, Germany

    Ethel-Michele de Villiers

  2. Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany

    Harald zur Hausen

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de Villiers, EM., Kimmel, R., Leppik, L., Gunst, K. (2009). Intragenomic Rearrangement in TT Viruses: A Possible Role in the Pathogenesis of Disease. In: de Villiers, EM., Hausen, H.z. (eds) TT Viruses. Current Topics in Microbiology and Immunology, vol 331. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-70972-5_6

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