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IFN-alpha in the Generation of Dendritic Cells for Cancer Immunotherapy

  • Chapter
Dendritic Cells

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 188))

Abstract

Dendritic cells (DCs) play a crucial role in linking innate and adaptive immunity, by virtue of their unique ability to take up and process antigens in the peripheral blood and tissues and, upon migration to draining lymph nodes, to present antigen to resting lymphocytes. Notably, these DC functions are modulated by cy-tokines and chemokines controlling the activation and maturation of these cells, thus shaping the response towards either immunity or tolerance.

An ensemble of recent studies have emphasized an important role of type I IFNs in the DC differentiation/activation, suggesting the existence of a natural alliance between these cytokines and DCs in linking innate and adaptive immunity. Herein, we will review how type I IFNs can promote the ex vivo differentiation of human DCs and orient DC functions towards the priming and expansion of protective antitumor immune responses. We will also discuss how the knowledge on type I IFN-DC interactions could be exploited for the design of more selective and effective strategies of cancer immunotherapy.

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References

  • Albert ML, Sauter B, Bhardwaj N (1998) Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 392:86–89

    Article  PubMed  CAS  Google Scholar 

  • Banchereau J, Pascual V (2006) Type I IFN in systemic lupus erythematosus and other autoimmune diseases. Immunity 25:383–392

    Article  PubMed  CAS  Google Scholar 

  • Banchereau J, Ueno H, Dhodapkar M, Connolly J, Finholt JP, Klechevsky E, Blanck JP, Johnston DA, Palucka AK, Fay J (2005) Immune and clinical outcomes in patients with stage IV melanoma vaccinated with peptide-pulsed dendritic cells derived from CD34+ progenitors and activated with type I interferon. J Immunother 28:505–516

    Article  PubMed  CAS  Google Scholar 

  • Barnes E, Salio M, Cerundolo V, Medlin J, Murphy S, Dusheiko G, Klenerman P (2004) Impact of alpha interferon and ribavirin on the function of maturing dendritic cells. Antimicrob Agents Chemother 48:3382–3389

    Article  PubMed  CAS  Google Scholar 

  • Bartholomé EJ, Willems F, Crusiaux A, Thielemans K, Schandene L, Goldman M (1999) IFN-beta interferes with the differentiation of dendritic cells from peripheral blood mononuclear cells: selective inhibition of CD40-dependent interleukin-12 secretion. J Interf Cytok Res 19:471–478

    Article  Google Scholar 

  • Belardelli F (1995) Role of interferons and other cytokines in the regulation of the immune response. APMIS 103:161–179

    PubMed  CAS  Google Scholar 

  • Belardelli F, Ferrantini M (2002) Cytokines as a link between innate and adaptive antitumor immunity. Trends Immunol 23:201–208

    Article  PubMed  CAS  Google Scholar 

  • Belardelli F, Gresser I (1996) The neglected role of type I interferon in the T-cell response: implications for its clinical use. Immunol Today 17:369–372

    Article  PubMed  CAS  Google Scholar 

  • Bell D, Young JW, Banchereau J (1999) Dendritic cells. Adv Immunol 72:255–324

    Article  PubMed  CAS  Google Scholar 

  • Blanco P, Palucka AK, Gill M, Pascual V, Banchereau J (2001) Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus. Science 294:1540–1543

    Article  PubMed  CAS  Google Scholar 

  • Boccaccio C, Jacod S, Kaiser A, Boyer A, Abastado JP, Nardin A (2002) Identification of a clinical-grade maturation factor for dendritic cells. J Immunother 25:88–96

    Article  PubMed  Google Scholar 

  • Buelens C, Bartholome EJ, Amraoui Z, Boutriaux M, Salmon I, Thielemans K, Willems F, Goldman M (2002) Interleukin-3 and interferon beta cooperate to induce differentiation of monocytes into dendritic cells with potent helper T-cell stimulatory properties. Blood 99:993– 998

    Article  PubMed  CAS  Google Scholar 

  • Carbonneil C, Aouba A, Burgard M, Cardinaud S, Rouzioux C, Langlade-Demoyen P, Weiss L (2003) Dendritic cells generated in the presence of granulocyte-macrophage colony-stimulating factor and IFN-alpha are potent inducers of HIV-specific CD8 T cells. AIDS 17:1731–1740

    Article  PubMed  CAS  Google Scholar 

  • Carbonneil C, Saidi H, Donkova-Petrini V, Weiss L (2004) Dendritic cells generated in the presence of interferon-alpha stimulate allogeneic CD4+ T-cell proliferation: modulation by autocrine IL-10, enhanced T-cell apoptosis and T regulatory type 1 cells. Int Immunol 16:1037–1052

    Article  PubMed  CAS  Google Scholar 

  • Caux C, Dezutter-Dambuyant C, Schmitt D, Banchereau J (1992) GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans cells. Nature 360:258–261

    Article  PubMed  CAS  Google Scholar 

  • Caux C, Vanbervliet B, Massacrier C, Dezutter-Dambuyant C, de Saint-Vis B, Jacquet C, Yoneda K, Imamura S, Schmitt D, Banchereau J (1996) CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha. J Exp Med 184:695–706

    Article  PubMed  CAS  Google Scholar 

  • Cella M, Jarrossay D, Facchetti F, Alebardi O, Nakajima H, Lanzavecchia A, Colonna M (1999) Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat Med 5:919–923

    Article  PubMed  CAS  Google Scholar 

  • Della Bella S, Nicola S, Riva A, Biasin M, Clerici M, Villa ML (2004) Functional repertoire of dendritic cells generated in granulocyte macrophage-colony stimulating factor and interferon-alpha. J Leukoc Biol 75:106–116

    Article  PubMed  CAS  Google Scholar 

  • Detournay O, Mazouz N, Goldman M, Toungouz M (2005) IL-6 produced by type I IFN DC controls IFN-gamma production by regulating the suppressive effect of CD4 +CD25+ regulatory T cells. Hum Immunol 66:460–468

    Article  PubMed  CAS  Google Scholar 

  • Dickensheets HL, Donnelly RP (1999) Inhibition of IL-4-inducible gene expression in human monocytes by type I and type II interferons. Leukoc Biol 65:307–312

    CAS  Google Scholar 

  • Di Pucchio T, Pilla L, Capone I, Ferrantini M, Montefiore E, Urbani F, Patuzzo R, Pennacchioli E, Santinami M, Cova A, Sovena G, Arienti F, Lombardo C, Lombardi A, Caporaso P, D'Atri S, Marchetti P, Bonmassar E, Parmiani G, Belardelli F, Rivoltini L (2006) Immunization of stage IV melanoma patients with Melan-A/MART-1 and gp100 peptides plus IFN-α results in the activation of specific CD8+ T cells and monocyte/dendritic cell precursors. Cancer Res 66:4943– 4951

    Article  PubMed  Google Scholar 

  • Durelli L, Ferrero B, Oggero A, Verdun E, Bongioanni MR, Gentile E, Isoardo GL, Ricci A, Rota E, Bergamasco B, Durazzo M, Saracco G, Biava MA, Brossa PC, Giorda L, Pagni R, Aimo G (1999) Autoimmune events during interferon beta-1b treatment for multiple sclerosis. J Neurol Sci 162:74–83

    Article  PubMed  CAS  Google Scholar 

  • Dussourd d'Hinterland L, Normier G, Durand J (1980) Ribosomal vaccines: preparation of sub-cellular fractions. Arzneimittelforschung 30:126–132

    PubMed  Google Scholar 

  • Ferrantini M, Capone I, Belardelli F (2007) Interferon-alpha and cancer: mechanisms of action and new perspectives of clinical use. Biochimie 89:884–893

    Article  PubMed  CAS  Google Scholar 

  • Ferrantini M, Capone I, Belardelli F (2008) Dendritic cells and cytokines in immune rejection of cancer. Cytokine Growth Factor Rev 19:93–107

    Article  PubMed  CAS  Google Scholar 

  • Gabriele L, Borghi P, Rozera C, Sestili P, Andreotti M, Guarini A, Montefusco E, Foà R, Belardelli F (2004) IFN-alpha promotes the rapid differentiation of monocytes from patients with chronic myeloid leukemia into activated dendritic cells tuned to undergo full maturation after LPS treatment. Blood 103:980–987

    Article  PubMed  CAS  Google Scholar 

  • Gauzzi MC, Canini I, Eid P, Belardelli F, Gessani S (2002) Loss of type I IFN receptors and impaired IFN responsiveness during terminal maturation of monocyte-derived human dendritic cells. J Immunol 169:3038–3045

    PubMed  CAS  Google Scholar 

  • Gilboa E (2007) DC-based cancer vaccines. J Clin Invest 117:1195–1203

    Article  PubMed  CAS  Google Scholar 

  • Gogas H, Ioannovich J, Dafni U, Stavropoulou-Giokas C, Frangia K, Tsoutsos D, Panagiotou P, Polyzos A, Papadopoulos O, Stratigos A, Markopoulos C, Bafaloukos D, Pectasides D, Fountzilas G, Kirkwood JM (2006) Prognostic significance of autoimmunity during treatment of melanoma with interferon. N Engl J Med 354:709–718

    Article  PubMed  CAS  Google Scholar 

  • Heath WR, Carbone FR (2001) Cross-presentation, dendritic cells, tolerance and immunity. Annu Rev Immunol 19:47–64

    Article  PubMed  CAS  Google Scholar 

  • Hermann P, Rubio M, Nakajima T, Delespesse G, Sarfati M (1998) IFN-alpha priming of human monocytes differentially regulates gram-positive and gram-negative bacteria-induced IL-10 release and selectively enhances IL-12p70, CD80, and MHC class I expression. J Immunol 161:2011–2018

    PubMed  CAS  Google Scholar 

  • Huang YM, Kouwenhoven M, Jin YP, Press R, Huang WX, Link H (2001) Dendritic cells derived from patients with multiple sclerosis show high CD1a and low CD86 expression. Mult Scler 7:95–99

    PubMed  CAS  Google Scholar 

  • Hunter CA (2005) New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat Rev Immunol 5:521–531

    Article  PubMed  CAS  Google Scholar 

  • Hussien Y, Sanna A, Soderstrom M, Link H, Huang YM (2001) Glatiramer acetate and IFN-beta act on dendritic cells in multiple sclerosis. J Neuroimmunol 121:102–110

    Article  PubMed  CAS  Google Scholar 

  • Ito T, Amakawa R, Inaba M, Ikehara S, Inaba K, Fukuhara S (2001) Differential regulation of human blood dendritic cell subsets by IFNs. J Immunol 166:2961–2969

    PubMed  CAS  Google Scholar 

  • Jonuleit H, Kühn U, Müller G, Steinbrink K, Paragnik L, Schmitt E, Knop J, Enk AH (1997a) Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur J Immunol 27:3135–3142

    Article  CAS  Google Scholar 

  • Jonuleit H, Wiedemann K, Müller G, Degwert J, Hoppe U, Knop J, Enk AH (1997b) Induction of IL-15 messenger RNA and protein in human blood-derived dendritic cells: a role for IL-15 in attraction of T cells. J Immunol 158:2610–2615

    CAS  Google Scholar 

  • Kalinski P, Schuitemaker JHN, Hilkens CMU, Wierenga EA, Kapsenberg ML (1999) Final maturation of dendritic cells is associated with impaired responsiveness to IFN-gamma and to bacterial IL-12 inducers: decreased ability of mature dendritic cells to produce IL-12 during the interaction with Th cells. J Immunol 162:3231–3236

    PubMed  CAS  Google Scholar 

  • Korthals M, Safaian N, Kronenwett R, Maihöfer D, Schott M, Papewalis C, Diaz Blanco E, Winter M, Czibere A, Haas R, Kobbe G, Fenk R (2007) Monocyte derived dendritic cells generated by IFN-alpha acquire mature dendritic and natural killer cell properties as shown by gene expression analysis. J Transl Med 5:46

    Article  PubMed  CAS  Google Scholar 

  • Langenkamp A, Messi M, Lanzavecchia A, Sallusto F (2000) Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells. Nat Immunol 1:311–316

    Article  PubMed  CAS  Google Scholar 

  • Lapenta C, Santini SM, Logozzi M, Spada M, Andreotti M, Di Pucchio T, Parlato S, Belardelli F (2003) Potent immune response against HIV-1 and protection from virus challenge in hu-PBL-SCID mice immunized with inactivated virus-pulsed dendritic cells generated in the presence of IFN-alpha. J Exp Med 198:361–367

    Article  PubMed  CAS  Google Scholar 

  • Lapenta C, Santini SM, Spada M, Donati S, Urbani F, Accapezzato D, Franceschini D, Andreotti M, Barnaba V, Belardelli F (2006) IFN-alpha-conditioned dendritic cells are highly efficient in inducing cross-priming CD8(+) T cells against exogenous viral antigens. Eur J Immunol 36:2046–2060

    Article  PubMed  CAS  Google Scholar 

  • Larner AC, Petricoin EF, Nakagawa Y, Finbloom DS (1993) IL-4 attenuates the transcriptional activation of both IFN-alpha and IFN-gamma-induced cellular gene expression in monocytes and monocytic cell lines. J Immunol 150:1944–1950

    PubMed  CAS  Google Scholar 

  • Liu YJ (2001) Dendritic cell subsets and lineages, and their functions in innate and adaptive immunity. Cell 106:259–262

    Article  PubMed  CAS  Google Scholar 

  • Luft T, Pang KC, Thomas E, Bradley CJ, Savoia H, Trapani J, Cebon J (1998a) A serum-free culture model for studying the differentiation of human dendritic cells from adult CD34+ progenitor cells. Exp Hematol 26:489–500

    CAS  Google Scholar 

  • Luft T, Pang KC, Thomas E, Hertzog P, Hart DN, Trapani J, Cebon J (1998b) Type I IFNs enhance the terminal differentiation of dendritic cells. J Immunol 161:1947–1953

    CAS  Google Scholar 

  • Luft T, Luetjens P, Hochrein H, Toy T, Masterman KA, Rizkalla M, Maliszewski C, Shortman K, Cebon J, Maraskovsky E (2002) IFN-alpha enhances CD40 ligand-mediated activation of immature monocyte-derived dendritic cells. Int Immunol 14:367–380

    Article  PubMed  CAS  Google Scholar 

  • Mazouz N, Detournay O, Buelens C, Renneson J, Trakatelli M, Lambermont M, Goldman M, Toungouz M (2005) Immunostimulatory properties of human dendritic cells generated using IFN-beta associated either with IL-3 or GM-CSF. Cancer Immunol Immunother 54:1010–1017

    Article  PubMed  CAS  Google Scholar 

  • McRae BL, Beilfuss BA, van Seventer GA (2000a) IFN-beta differentially regulates CD40-induced cytokine secretion by human dendritic cells. J Immunol 164:23–28

    CAS  Google Scholar 

  • McRae BL, Nagai T, Semnani RT, van Seventer JM, van Seventer GA (2000b) Interferon-alpha and -beta inhibit the in vitro differentiation of immunocompetent human dendritic cells from CD14(+) precursors. Blood 96:210–217

    CAS  Google Scholar 

  • Melero I, Arina A, Murillo O, Dubrot J, Alfaro C, Pérez-Gracia JL, Bendandi M, Hervás-Stubbs S (2006) Immunogenic cell death and cross-priming are reaching the clinical immunotherapy arena. Clin Cancer Res 12:2385–2389

    Article  PubMed  CAS  Google Scholar 

  • Mohty M, Vialle-Castellano A, Nunes JA, Isnardon D, Olive D, Gaugler B (2003) IFN-alpha skews monocyte differentiation into Toll-like receptor 7-expressing dendritic cells with potent functional activities. J Imm 171:3385–3393

    CAS  Google Scholar 

  • Nagai T, Devergne O, Mueller TF, Perkins DL, van Seventer JM, van Seventer GA (2003) Timing of IFN-beta exposure during human dendritic cell maturation and naive Th cell stimulation has contrasting effects on Th1 subset generation: a role for IFN-beta-mediated regulation of IL-12 family cytokines and IL-18 in naive Th cell differentiation. J Immunol 171:5233–5243

    PubMed  CAS  Google Scholar 

  • Napolitani G, Rinaldi A, Bertoni F, Sallusto F and Lanzavecchia A (2005) Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nat Immunol 6:769–776

    Article  PubMed  CAS  Google Scholar 

  • Ohmori Y, Hamilton TA (1998) STAT6 is required for the anti-inflammatory activity of interleukin-4 in mouse peritoneal macrophages. J Biol Chem 273:29202–29209

    Article  PubMed  CAS  Google Scholar 

  • Padovan E, Spagnoli GC, Ferrantini M, Heberer M (2002) IFN-alpha2a induces IP-10/CXCL10 and MIG/CXCL9 production in monocyte-derived dendritic cells and enhances their capacity to attract and stimulate CD8+ effector T cells. J Leuk Biol 71:669–676

    CAS  Google Scholar 

  • Papewalis C, Jacobs B, Wuttke M, Ullrich E, Baehring T, Fenk R, Willenberg HS, Schinner S, Cohnen M, Seissler J, Zacharowski K, Scherbaum WA, Schott M (2008a) IFN-alpha skews monocytes into CD56+-expressing dendritic cells with potent functional activities in vitro and in vivo. J Immunol 180:1462–1470

    CAS  Google Scholar 

  • Papewalis C, Wuttke M, Jacobs B, Domberg J, Willenberg H, Baehring T, Cupisti K, Raffel A, Chao L, Fenk R, Seissler J, Scherbaum WA, Schott M (2008b) Dendritic cell vaccination induces tumor epitope-specific Th1 immune response in medullary thyroid carcinoma. Horm Metab Res 40:108–116

    Article  CAS  Google Scholar 

  • Paquette RL, Hsu NC, Kiertscher SM, Park AN, Tran L, Roth MD, Glaspy JA (1998) Interferon-alpha and granulocyte-macrophage colony-stimulating factor differentiate peripheral blood monocytes into potent antigen-presenting cells. J Leukoc Biol 64:358–367

    PubMed  CAS  Google Scholar 

  • Parlato S, Santini SM, Lapenta C, Di Pucchio T, Logozzi M, Spada M, Giammarioli AM, Malorni W, Fais S, Belardelli F (2001) Expression of CCR-7, MIP-3beta, and Th-1 chemokines in type I IFN-induced monocyte-derived dendritic cells: importance for the rapid acquisition of potent migratory and functional activities. Blood 98:3022–3029

    Article  PubMed  CAS  Google Scholar 

  • Pogue SL, Preston BT, Stalder J, Bebbington CR, Cardarelli PM (2004) The receptor for type I IFNs is highly expressed on peripheral blood B cells and monocytes and mediates a distinct profile of differentiation and activation of these cells. J Interferon Cytokine Res 24:131–139

    Article  PubMed  CAS  Google Scholar 

  • Preziati D, La Rosa L, Covini G, Marcelli R, Rescalli S, Persani L, Del Ninno E, Meroni PL, Colombo M, Beck-Peccoz P (1995) Autoimmunity and thyroid function in patients with chronic active hepatitis treated with recombinant interferon alpha-2a. Eur J Endocrinol 132:587–593

    Article  PubMed  CAS  Google Scholar 

  • Radvanyi LG, Banerjee A, Weir M, Messner H (1999) Low levels of interferon-alpha induce CD86 (B7.2) expression and accelerates dendritic cell maturation from human peripheral blood mononuclear cells. Scand J Immunol 50:499–509

    Article  PubMed  CAS  Google Scholar 

  • Renneson J, Salio M, Mazouz N, Goldman M, Marchant A, Cerundolo V (2005) Mature dendritic cells differentiated in the presence of interferon-beta and interleukin-3 prime functional antigen-specific CD8 T cells. Clin Exp Immunol 139:468–475

    Article  PubMed  CAS  Google Scholar 

  • Rivoltini L, Barracchini KC, Viggiano V, Kawakami Y, Smith A, Mixon A, Restifo NP, Topalian SL, Simonis TB, Rosenberg SA, Francesco MM (1995) Quantitative correlation between HLA class I allele expression and recognition of melanoma cells by antigen-specific cytotoxic T lymphocytes. Cancer Res 55:3149–3157

    PubMed  CAS  Google Scholar 

  • Romani N, Gruner S, Brang D, Kampgen E, Lenz A, Trockenbacher B, Konwalinka G, Fritsch PO, Steinman RM, Schuler G (1994) Proliferating dendritic cell progenitors in human blood. J Exp Med 180:83–93

    Article  PubMed  CAS  Google Scholar 

  • Ronnblom LE, Alm GV, Oberg K (1991) Autoimmune phenomena in patients with malignant carcinoid tumors during interferon-alpha treatment. Acta Oncol 30:537–540

    Article  PubMed  CAS  Google Scholar 

  • Sallusto F, Lanzavecchia A (1994) Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 179:1109–1118

    Article  PubMed  CAS  Google Scholar 

  • Sallusto F, Mackay CR, Lanzavecchia A (2000) The role of chemokine receptors in primary, effector, and memory immune responses. Annu Rev Immunol 18:593–620

    Article  PubMed  CAS  Google Scholar 

  • Santini SM, Lapenta C, Logozzi M, Parlato S, Spada M, Di Pucchio T, Belardelli F (2000) Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-SCID mice. J Exp Med 191:1777–1788

    Article  PubMed  CAS  Google Scholar 

  • Santodonato L, D'Agostino G, Nisini R, Mariotti S, Monque DM, Spada M, Lattanzi L, Perrone MP, Andreotti M, Belardelli F, Ferrantini M (2003) Monocyte-derived dendritic cells generated after a short-term culture with IFN-alpha and granulocyte-macrophage colony-stimulating factor stimulate a potent Epstein-Barr virus-specific CD8+ T cell response. J Immunol 170:5195–5202

    PubMed  CAS  Google Scholar 

  • Siegal FP, Kadowaki N, Shodell M, Fitzgerald-Bocarsly PA, Shah K, Ho S, Antonenko S, Liu YJ (1999) The nature of the principal type 1 interferon-producing cells in human blood. Science 284:1835–1837

    Article  PubMed  CAS  Google Scholar 

  • Steinbrink K, Wolfl M, Jonuleit H, Knop J, Enk AH (1997) Induction of tolerance by IL-10-treated dendritic cells. J Immunol 159:4772–4780

    PubMed  CAS  Google Scholar 

  • Steinbrink K, Jonuleit H, Muller G, Schuler G, Knop J, Enk AH (1999) Interleukin-10-treated human dendritic cells induce a melanoma-antigen-specific anergy in CD8(+) T cells resulting in a failure to lyse tumor cells. Blood 93:1634–1642

    PubMed  CAS  Google Scholar 

  • Steinman RM (2003) The control of immunity and tolerance by dendritic cell. Pathol Biol 51:59–60

    Article  PubMed  CAS  Google Scholar 

  • Steinman RM, Banchereau J (2007) Taking dendritic cells into medicine. Nature 449:419–426

    Article  PubMed  CAS  Google Scholar 

  • Steinman RM, Hemmi H (2006) Dendritic cells: translating innate to adaptive immunity. Curr Top Microbiol Immunol 311:17–58

    Article  PubMed  CAS  Google Scholar 

  • Tesniere A, Panaretakis T, Kepp O, Apetoh L, Ghiringhelli F, Zitvogel L, Kroemer G (2008) Molecular characteristics of immunogenic cancer cell death. Cell Death Differ 15:3–12

    Article  PubMed  CAS  Google Scholar 

  • Thurnher M, Zelle-Rieser C, Ramoner R, Bartsch G, Holtl L (2001) The disabled dendritic cell. Faseb J 15:1054–1061

    Article  PubMed  CAS  Google Scholar 

  • Tosi D, Valenti R, Cova A, Sovena G, Huber V, Pilla L, Arienti F, Belardelli F, Parmiani G, Rivoltini L (2004) Role of cross-talk between IFN-alpha-induced monocyte-derived dendritic cells and NK cells in priming CD8+ T cell responses against human tumor antigens. J Immunol 172:5363–5370

    PubMed  CAS  Google Scholar 

  • Trakatelli M, Toungouz M, Blocklet D, Dodoo Y, Gordower L, Laporte M, Vereecken P, Sales F, Mortier L, Mazouz N, Lambermont M, Goldman S, Coulie P, Goldman M, Velu T (2006) A new dendritic cell vaccine generated with interleukin-3 and interferon-beta induces CD8+ T cell responses against NA17-A2 tumor peptide in melanoma patients. Cancer Immunol Immunother 55:469–474

    Article  PubMed  CAS  Google Scholar 

  • Wiesemann E, Sonmez D, Heidenreich F, Windhagen A (2002) Interferon-beta increases the stimulatory capacity of monocyte-derived dendritic cells to induce IL-13, IL-5 and IL-10 in autol-ogous T-cells. J Neuroimmunol 123:160–169

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Section of Experimental Immunotherapy, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena, Rome, 299, 00161, Italy

    Stefano Maria Santini, Caterina Lapenta, Laura Santodonato, Giuseppina D'Agostino, Filippo Belardelli & Maria Ferrantini

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  1. Stefano Maria Santini
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  2. Caterina Lapenta
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  3. Laura Santodonato
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  4. Giuseppina D'Agostino
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  5. Filippo Belardelli
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  6. Maria Ferrantini
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Correspondence to Stefano Maria Santini .

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Editors and Affiliations

  1. DIIID, King's College, London School of Medicine, Guy's Hospital, London, UK

    Giovanna Lombardi (Professor of Human Transplant Immunology MRC Centre in Transplantation Dep. of Nephrology and Transplantation) (Professor of Human Transplant Immunology MRC Centre in Transplantation Dep. of Nephrology and Transplantation)

  2. 5th Floor Hodgkin Building, School of Biomedical and Health Sciences, King's College London, London, SE1 1UL, United Kingdom

    Yanira Riffo-Vasquez (Research Fellow The Sackler Institute of Pulmonary Pharmacology Pharmaceutical Science Division) (Research Fellow The Sackler Institute of Pulmonary Pharmacology Pharmaceutical Science Division)

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Santini, S.M., Lapenta, C., Santodonato, L., D'Agostino, G., Belardelli, F., Ferrantini, M. (2009). IFN-alpha in the Generation of Dendritic Cells for Cancer Immunotherapy. In: Lombardi, G., Riffo-Vasquez, Y. (eds) Dendritic Cells. Handbook of Experimental Pharmacology, vol 188. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-71029-5_14

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