Abstract
In this paper, we study a hybrid automaton model of the lac operon regulating lactose metabolism in E. Coli. We identify two stationary conditions for the system corresponding to lactose metabolism being induced/uninduced, and characterize the extra-cellular concentrations of glucose and lactose that are compatible with them. We also investigate conditions for switching between the two identified stationary conditions.
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Farina, M., Prandini, M. (2007). Hybrid Models for Gene Regulatory Networks: The Case of lac Operon in E. Coli. In: Bemporad, A., Bicchi, A., Buttazzo, G. (eds) Hybrid Systems: Computation and Control. HSCC 2007. Lecture Notes in Computer Science, vol 4416. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-71493-4_63
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DOI: https://doi.org/10.1007/978-3-540-71493-4_63
Publisher Name: Springer, Berlin, Heidelberg
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