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The Synergy of Two Ovarian Hormone-induced Enzymes in Human Mammary Carcinogenesis

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Hormonal Control of Cell Cycle

Part of the book series: Research and Perspectives in Endocrine Interactions ((RPEI))

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Abstract

Estrogens and progestins synergize to increase the risk of breast cancer in post menopausal patients. Two house keeping enzymes, the estrogen-induced cathepsin D and the progestin-induced Fatty Acid Synthase (FAS) that we identified in hormone responsive breast cancer cell lines give a partial explanation for this synergy. Both cathepsin D and FAS are also induced by growth factors, their overexpression in breast cancers has a bad prognostic significance and their inhibition in nude mice decrease mammary tumor growth. The mechanism of their in vivo activity might be mediated by the internal production of nutrients allowing cancer cells to grow in restricted conditions. Their overexpression in pre invasive breast lesions is independent and occurs in both ERα positive and ERα negative breast cancers.

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Author information

Authors and Affiliations

  1. CRLC Val d’Aurelle Bat B Cancer Research Center, Cedex 5, 34298, Montpellier, France

    Henri Rochefort

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  1. Henri Rochefort
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Editor information

Editors and Affiliations

  1. Cedars-Sinai Medical Center, 8700 Beverly Blvd. Room 2015, CA 90048, Los Angeles, USA

    Shlomo Melmed

  2. CRLC Val d’Aurelle Bat B Cancer Research Center, 34298, Monpellier Cedex 5, France

    Henri Rochefort

  3. Service d’Endocrinologie, Hˆopital Bicˆetre, 78, avenue de G´eneral Leclerc, 94275, Kremlin-Bicˆetre, France

    Phillipe Chanson

  4. Pour la Recherche Thérapeutique, Fondation IPSEN, 24, rue Erlanger, 75781, Paris Cedex 16, France

    Yves Christen

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© 2008 Springer-Verlag Berlin Heidelberg

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Rochefort, H. (2008). The Synergy of Two Ovarian Hormone-induced Enzymes in Human Mammary Carcinogenesis. In: Melmed, S., Rochefort, H., Chanson, P., Christen, Y. (eds) Hormonal Control of Cell Cycle. Research and Perspectives in Endocrine Interactions. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-73855-8_10

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